Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates
Background/Aims Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the association between lumican concentrations and osteoporosis-related...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2022-07-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://kjim.org/upload/pdf/kjim-2022-015.pdf |
| _version_ | 1811324298580721664 |
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| author | Yun Sun Lee So Jeong Park Jin Young Lee Eunah Choi Beom-Jun Kim |
| author_facet | Yun Sun Lee So Jeong Park Jin Young Lee Eunah Choi Beom-Jun Kim |
| author_sort | Yun Sun Lee |
| collection | DOAJ |
| description | Background/Aims Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the association between lumican concentrations and osteoporosis-related phenotypes was evaluated using bone marrow (BM) samples directly reflecting local microenvironments. Methods BM aspirates were obtained from 77 patients during hip surgery for either fragility hip fractures (HF) (n = 29) or osteoarthritis (n = 48) and centrifuged. Concentrations of lumican and biochemical bone markers in BM supernatants were measured using enzyme linked immunosorbent assays. Results After considering confounders, lumican concentrations in BM supernatants were 16.9% lower in patients with HF than in controls, with each increase in the standard deviation of lumican concentration being associated with a 61% lower likelihood of HF. The odds ratios for HF decreased linearly with increasing lumican tertiles in BM, with the odds of having fragility HF markedly lower in participants in the highest than in the lowest lumican tertile. Higher lumican level correlated significantly with higher femur neck bone mineral density and higher bone-specific alkaline phosphatase levels, but not with tartrate-resistant acid phosphatase 5b concentrations, in BM supernatants. Conclusions These data clinically validate previous in vitro and animal experiments showing the beneficial roles of lumican for bone homeostasis and suggest that lumican may contribute to a reduction in fracture risk in humans mainly through its stimulation of bone formation. |
| first_indexed | 2024-04-13T14:11:53Z |
| format | Article |
| id | doaj.art-2fdafde8192441e88ac141e78b0a2328 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-04-13T14:11:53Z |
| publishDate | 2022-07-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-2fdafde8192441e88ac141e78b0a23282022-12-22T02:43:45ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482022-07-0137482182910.3904/kjim.2022.015170674Benefits of lumican on human bone health: clinical evidence using bone marrow aspiratesYun Sun Lee0So Jeong Park1Jin Young Lee2Eunah Choi3Beom-Jun Kim4 Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the association between lumican concentrations and osteoporosis-related phenotypes was evaluated using bone marrow (BM) samples directly reflecting local microenvironments. Methods BM aspirates were obtained from 77 patients during hip surgery for either fragility hip fractures (HF) (n = 29) or osteoarthritis (n = 48) and centrifuged. Concentrations of lumican and biochemical bone markers in BM supernatants were measured using enzyme linked immunosorbent assays. Results After considering confounders, lumican concentrations in BM supernatants were 16.9% lower in patients with HF than in controls, with each increase in the standard deviation of lumican concentration being associated with a 61% lower likelihood of HF. The odds ratios for HF decreased linearly with increasing lumican tertiles in BM, with the odds of having fragility HF markedly lower in participants in the highest than in the lowest lumican tertile. Higher lumican level correlated significantly with higher femur neck bone mineral density and higher bone-specific alkaline phosphatase levels, but not with tartrate-resistant acid phosphatase 5b concentrations, in BM supernatants. Conclusions These data clinically validate previous in vitro and animal experiments showing the beneficial roles of lumican for bone homeostasis and suggest that lumican may contribute to a reduction in fracture risk in humans mainly through its stimulation of bone formation.http://kjim.org/upload/pdf/kjim-2022-015.pdflumicanhip fracturesosteogenesisbone resorptionbone density |
| spellingShingle | Yun Sun Lee So Jeong Park Jin Young Lee Eunah Choi Beom-Jun Kim Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates The Korean Journal of Internal Medicine lumican hip fractures osteogenesis bone resorption bone density |
| title | Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates |
| title_full | Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates |
| title_fullStr | Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates |
| title_full_unstemmed | Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates |
| title_short | Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates |
| title_sort | benefits of lumican on human bone health clinical evidence using bone marrow aspirates |
| topic | lumican hip fractures osteogenesis bone resorption bone density |
| url | http://kjim.org/upload/pdf/kjim-2022-015.pdf |
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