Unlocking the Potential of Stem Cell Microenvironments In Vitro
The field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/3/289 |
| _version_ | 1827307010003042304 |
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| author | Chiara Scodellaro Raquel R. Pina Frederico Castelo Ferreira Paola Sanjuan-Alberte Tiago G. Fernandes |
| author_facet | Chiara Scodellaro Raquel R. Pina Frederico Castelo Ferreira Paola Sanjuan-Alberte Tiago G. Fernandes |
| author_sort | Chiara Scodellaro |
| collection | DOAJ |
| description | The field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known as microenvironments or niches, which play critical roles in regulating stem cell behavior and determining their fate. Therefore, understanding the complex microenvironments that surround stem cells is crucial for advancing treatment options in regenerative medicine and tissue engineering applications. Several research articles have made significant contributions to this field by exploring the interactions between stem cells and their surrounding niches, investigating the influence of biomechanical and biochemical cues, and developing innovative strategies for tissue regeneration. This review highlights the key findings and contributions of these studies, shedding light on the diverse applications that may arise from the understanding of stem cell microenvironments, thus harnessing the power of these microenvironments to transform the landscape of medicine and offer new avenues for regenerative therapies. |
| first_indexed | 2024-04-24T18:32:05Z |
| format | Article |
| id | doaj.art-2fdfb4ae385d4969a34f76d388a8755f |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-04-24T18:32:05Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-2fdfb4ae385d4969a34f76d388a8755f2024-03-27T13:21:59ZengMDPI AGBioengineering2306-53542024-03-0111328910.3390/bioengineering11030289Unlocking the Potential of Stem Cell Microenvironments In VitroChiara Scodellaro0Raquel R. Pina1Frederico Castelo Ferreira2Paola Sanjuan-Alberte3Tiago G. Fernandes4Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalThe field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known as microenvironments or niches, which play critical roles in regulating stem cell behavior and determining their fate. Therefore, understanding the complex microenvironments that surround stem cells is crucial for advancing treatment options in regenerative medicine and tissue engineering applications. Several research articles have made significant contributions to this field by exploring the interactions between stem cells and their surrounding niches, investigating the influence of biomechanical and biochemical cues, and developing innovative strategies for tissue regeneration. This review highlights the key findings and contributions of these studies, shedding light on the diverse applications that may arise from the understanding of stem cell microenvironments, thus harnessing the power of these microenvironments to transform the landscape of medicine and offer new avenues for regenerative therapies.https://www.mdpi.com/2306-5354/11/3/289stem cellscellular nichesmicroenvironmentsbiomechanical and biochemical cuesregenerative medicine |
| spellingShingle | Chiara Scodellaro Raquel R. Pina Frederico Castelo Ferreira Paola Sanjuan-Alberte Tiago G. Fernandes Unlocking the Potential of Stem Cell Microenvironments In Vitro Bioengineering stem cells cellular niches microenvironments biomechanical and biochemical cues regenerative medicine |
| title | Unlocking the Potential of Stem Cell Microenvironments In Vitro |
| title_full | Unlocking the Potential of Stem Cell Microenvironments In Vitro |
| title_fullStr | Unlocking the Potential of Stem Cell Microenvironments In Vitro |
| title_full_unstemmed | Unlocking the Potential of Stem Cell Microenvironments In Vitro |
| title_short | Unlocking the Potential of Stem Cell Microenvironments In Vitro |
| title_sort | unlocking the potential of stem cell microenvironments in vitro |
| topic | stem cells cellular niches microenvironments biomechanical and biochemical cues regenerative medicine |
| url | https://www.mdpi.com/2306-5354/11/3/289 |
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