Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model and show that major features of NASH can be r...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02616-x |
| _version_ | 1818344699861139456 |
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| author | Tomasz Kostrzewski Sophie Snow Anya Lindström Battle Samantha Peel Zahida Ahmad Jayati Basak Manasa Surakala Aurelie Bornot Julia Lindgren Maria Ryaboshapkina Maryam Clausen Daniel Lindén Christian Maass Lucy May Young Adam Corrigan Lorna Ewart David Hughes |
| author_facet | Tomasz Kostrzewski Sophie Snow Anya Lindström Battle Samantha Peel Zahida Ahmad Jayati Basak Manasa Surakala Aurelie Bornot Julia Lindgren Maria Ryaboshapkina Maryam Clausen Daniel Lindén Christian Maass Lucy May Young Adam Corrigan Lorna Ewart David Hughes |
| author_sort | Tomasz Kostrzewski |
| collection | DOAJ |
| description | Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model and show that major features of NASH can be recapitulated and therapeutic interventions mimicked. |
| first_indexed | 2024-12-13T16:50:38Z |
| format | Article |
| id | doaj.art-2fe033487d4045ff86e6fb36c7f3e8b7 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-13T16:50:38Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-2fe033487d4045ff86e6fb36c7f3e8b72022-12-21T23:38:03ZengNature PortfolioCommunications Biology2399-36422021-09-014111510.1038/s42003-021-02616-xModelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological systemTomasz Kostrzewski0Sophie Snow1Anya Lindström Battle2Samantha Peel3Zahida Ahmad4Jayati Basak5Manasa Surakala6Aurelie Bornot7Julia Lindgren8Maria Ryaboshapkina9Maryam Clausen10Daniel Lindén11Christian Maass12Lucy May Young13Adam Corrigan14Lorna Ewart15David Hughes16CN Bio Innovations LtdCN Bio Innovations LtdCN Bio Innovations LtdDiscovery Biology, Discovery Sciences, R&D, AstraZenecaTranslational Biomarkers and Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZenecaTranslational Biomarkers and Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZenecaR&D IT, AstraZenecaQuantitative Biology and Data Science, Discovery Sciences, R&D, AstraZenecaTranslational Genomics, Discovery Biology, Discovery Sciences, R&D, AstraZenecaTranslational Science and Experimental Medicine, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZenecaTranslational Genomics, Discovery Biology, Discovery Sciences, R&D, AstraZenecaBioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZenecaCertara, Quantitative Systems Pharmacology UnitCN Bio Innovations LtdQuantitative Biology and Data Science, Discovery Sciences, R&D, AstraZenecaTranslational Biomarkers and Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZenecaCN Bio Innovations LtdKostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model and show that major features of NASH can be recapitulated and therapeutic interventions mimicked.https://doi.org/10.1038/s42003-021-02616-x |
| spellingShingle | Tomasz Kostrzewski Sophie Snow Anya Lindström Battle Samantha Peel Zahida Ahmad Jayati Basak Manasa Surakala Aurelie Bornot Julia Lindgren Maria Ryaboshapkina Maryam Clausen Daniel Lindén Christian Maass Lucy May Young Adam Corrigan Lorna Ewart David Hughes Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system Communications Biology |
| title | Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system |
| title_full | Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system |
| title_fullStr | Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system |
| title_full_unstemmed | Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system |
| title_short | Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system |
| title_sort | modelling human liver fibrosis in the context of non alcoholic steatohepatitis using a microphysiological system |
| url | https://doi.org/10.1038/s42003-021-02616-x |
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