Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China
BackgroundDemographic information has been shown to help predict high antibody titers of COVID-19 convalescent plasma (CCP) in CCP donors. However, there is no research on the Chinese population and little evidence on whole-blood donors. Therefore, we aimed to investigate these associations among Ch...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1191479/full |
| _version_ | 1797634952633778176 |
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| author | Jingyun Tang Humin Liu Qing Wang Xiaobo Gu Jia Wang Wenjun Li Yinglan Luo Yan Li Lan Deng Yue Luo Xinman Du Donglin Tan Xuemei Fu Xue Chen |
| author_facet | Jingyun Tang Humin Liu Qing Wang Xiaobo Gu Jia Wang Wenjun Li Yinglan Luo Yan Li Lan Deng Yue Luo Xinman Du Donglin Tan Xuemei Fu Xue Chen |
| author_sort | Jingyun Tang |
| collection | DOAJ |
| description | BackgroundDemographic information has been shown to help predict high antibody titers of COVID-19 convalescent plasma (CCP) in CCP donors. However, there is no research on the Chinese population and little evidence on whole-blood donors. Therefore, we aimed to investigate these associations among Chinese blood donors after SARS-CoV-2 infection.MethodsIn this cross-sectional study, 5,064 qualified blood donors with confirmed or suspected SARS-CoV-2 infection completed a self-reported questionnaire and underwent tests of SARS-CoV-2 Immunoglobulin G (IgG) antibody and ABO blood type. Logistic regression models were used to calculate odds ratios (ORs) for high SARS-CoV-2 IgG titers according to each factor.ResultsTotally, 1,799 participants (with SARS-CoV-2 IgG titers≥1:160) had high-titer CCPs. Multivariable analysis showed that a 10-year increment in age and earlier donation were associated with higher odds of high-titer CCP, while medical personnel was associated with lower odds. The ORs (95% CIs) of high-titer CCP were 1.17 (1.10–1.23, p< 0.001) and 1.41 (1.25-1.58, p< 0.001) for each 10-year increment in age and earlier donation, respectively. The OR of high-titer CCP was 0.75 (0.60-0.95, p = 0.02) for medical personnel. Female early donors were associated with increased odds of high-titer CCP, but this association was insignificant for later donors. Donating after 8 weeks from the onset was associated with decreased odds of having high-titer CCP compared to donating within 8 weeks from the onset, and the HR was 0.38 (95% CI: 0.22-0.64, p <0.001). There was no significant association between ABO blood type or race and the odds of high-titer CCP.DiscussionOlder age, earlier donation, female early donors, and non-medical-related occupations are promising predictors of high-titer CCP in Chinese blood donors. Our findings highlight the importance of CCP screening at the early stage of the pandemic. |
| first_indexed | 2024-03-11T12:14:32Z |
| format | Article |
| id | doaj.art-2fe05a29b6f34e51b11dad9bcd565caa |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T12:14:32Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2fe05a29b6f34e51b11dad9bcd565caa2023-11-07T10:17:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11914791191479Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in ChinaJingyun Tang0Humin Liu1Qing Wang2Xiaobo Gu3Jia Wang4Wenjun Li5Yinglan Luo6Yan Li7Lan Deng8Yue Luo9Xinman Du10Donglin Tan11Xuemei Fu12Xue Chen13Blood Research Laboratory, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Testing, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Collection, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Collection, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Collection, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Testing, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Testing, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Collection, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Collection, Chengdu Blood Center, Chengdu, Sichuan, ChinaBlood Research Laboratory, Chengdu Blood Center, Chengdu, Sichuan, ChinaBlood Research Laboratory, Chengdu Blood Center, Chengdu, Sichuan, ChinaDepartment of Blood Processing, Chengdu Blood Center, Chengdu, Sichuan, ChinaBlood Research Laboratory, Chengdu Blood Center, Chengdu, Sichuan, ChinaBlood Research Laboratory, Chengdu Blood Center, Chengdu, Sichuan, ChinaBackgroundDemographic information has been shown to help predict high antibody titers of COVID-19 convalescent plasma (CCP) in CCP donors. However, there is no research on the Chinese population and little evidence on whole-blood donors. Therefore, we aimed to investigate these associations among Chinese blood donors after SARS-CoV-2 infection.MethodsIn this cross-sectional study, 5,064 qualified blood donors with confirmed or suspected SARS-CoV-2 infection completed a self-reported questionnaire and underwent tests of SARS-CoV-2 Immunoglobulin G (IgG) antibody and ABO blood type. Logistic regression models were used to calculate odds ratios (ORs) for high SARS-CoV-2 IgG titers according to each factor.ResultsTotally, 1,799 participants (with SARS-CoV-2 IgG titers≥1:160) had high-titer CCPs. Multivariable analysis showed that a 10-year increment in age and earlier donation were associated with higher odds of high-titer CCP, while medical personnel was associated with lower odds. The ORs (95% CIs) of high-titer CCP were 1.17 (1.10–1.23, p< 0.001) and 1.41 (1.25-1.58, p< 0.001) for each 10-year increment in age and earlier donation, respectively. The OR of high-titer CCP was 0.75 (0.60-0.95, p = 0.02) for medical personnel. Female early donors were associated with increased odds of high-titer CCP, but this association was insignificant for later donors. Donating after 8 weeks from the onset was associated with decreased odds of having high-titer CCP compared to donating within 8 weeks from the onset, and the HR was 0.38 (95% CI: 0.22-0.64, p <0.001). There was no significant association between ABO blood type or race and the odds of high-titer CCP.DiscussionOlder age, earlier donation, female early donors, and non-medical-related occupations are promising predictors of high-titer CCP in Chinese blood donors. Our findings highlight the importance of CCP screening at the early stage of the pandemic.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1191479/fullSARS-CoV-2 IgG titerconvalescent plasma screeningCOVID-19Chinesecross-sectional studywhole-blood donors |
| spellingShingle | Jingyun Tang Humin Liu Qing Wang Xiaobo Gu Jia Wang Wenjun Li Yinglan Luo Yan Li Lan Deng Yue Luo Xinman Du Donglin Tan Xuemei Fu Xue Chen Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China Frontiers in Immunology SARS-CoV-2 IgG titer convalescent plasma screening COVID-19 Chinese cross-sectional study whole-blood donors |
| title | Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China |
| title_full | Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China |
| title_fullStr | Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China |
| title_full_unstemmed | Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China |
| title_short | Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China |
| title_sort | predictors of high sars cov 2 immunoglobulin g titers in covid 19 convalescent whole blood donors a cross sectional study in china |
| topic | SARS-CoV-2 IgG titer convalescent plasma screening COVID-19 Chinese cross-sectional study whole-blood donors |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1191479/full |
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