A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis
Postoperative endophthalmitis (POE) has been the most threatening complication after cataract surgery, which perhaps can be solved by the antibiotic-loaded intraocular lens (IOL). However, most drug-loaded IOLs demonstrate insufficient drug quantity, short release time, increased implantation-relate...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-02-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22002535 |
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| author | Mengna Li Jing-Wei Xu Jiayong Li Wei Wang Chenqi Luo Haijie Han Zhi-Kang Xu Ke Yao |
| author_facet | Mengna Li Jing-Wei Xu Jiayong Li Wei Wang Chenqi Luo Haijie Han Zhi-Kang Xu Ke Yao |
| author_sort | Mengna Li |
| collection | DOAJ |
| description | Postoperative endophthalmitis (POE) has been the most threatening complication after cataract surgery, which perhaps can be solved by the antibiotic-loaded intraocular lens (IOL). However, most drug-loaded IOLs demonstrate insufficient drug quantity, short release time, increased implantation-related difficulties or other noticeable drawbacks. To prevent POE and to address these deficiencies, a drug-loaded copolymer IOL, prepared from poly (urethane acrylate) prepolymer, isobornyl methacrylate (IBOMA), N-vinyl-2-pyrrolidone (NVP), Irgacure 819, RUVA-93, and gatifloxacin (GAT), was rapidly fabricated via photocuring and by using a 3D-printed mold. This composite displayed an outstanding and controllable GAT release behavior in vitro, a high light transmittance, and a moderate refractive index. Also, it demonstrated improved strain stress and elongation compared with the reference commercial acrylic IOL material. In vivo tests demonstrated satisfying released drug concentration at the early treatment stage. In vitro and in vivo studies further confirmed the remarkable bacterial inhibition and prevention of POE by the proposed IOL, which also displayed good biocompatibility. These findings suggested that the GAT-loaded IOL could be a promising implant to prevent and cure POE, also the proposed methods could inspire more designs for various medical applications. |
| first_indexed | 2024-04-12T00:00:18Z |
| format | Article |
| id | doaj.art-2fe1c7857659468b82b0fd72b9751cb4 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:40:48Z |
| publishDate | 2023-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-2fe1c7857659468b82b0fd72b9751cb42024-04-16T15:59:09ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-02-0120271285A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitisMengna Li0Jing-Wei Xu1Jiayong Li2Wei Wang3Chenqi Luo4Haijie Han5Zhi-Kang Xu6Ke Yao7Eye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China; Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, 310009, PR ChinaEye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China; Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, 310009, PR ChinaEye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China; Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, 310009, PR ChinaEye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR ChinaEye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China; Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, 310009, PR ChinaEye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China; Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, 310009, PR ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, PR China; Corresponding author.Eye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China; Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, 310009, PR China; Corresponding author. Eye Center, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China.Postoperative endophthalmitis (POE) has been the most threatening complication after cataract surgery, which perhaps can be solved by the antibiotic-loaded intraocular lens (IOL). However, most drug-loaded IOLs demonstrate insufficient drug quantity, short release time, increased implantation-related difficulties or other noticeable drawbacks. To prevent POE and to address these deficiencies, a drug-loaded copolymer IOL, prepared from poly (urethane acrylate) prepolymer, isobornyl methacrylate (IBOMA), N-vinyl-2-pyrrolidone (NVP), Irgacure 819, RUVA-93, and gatifloxacin (GAT), was rapidly fabricated via photocuring and by using a 3D-printed mold. This composite displayed an outstanding and controllable GAT release behavior in vitro, a high light transmittance, and a moderate refractive index. Also, it demonstrated improved strain stress and elongation compared with the reference commercial acrylic IOL material. In vivo tests demonstrated satisfying released drug concentration at the early treatment stage. In vitro and in vivo studies further confirmed the remarkable bacterial inhibition and prevention of POE by the proposed IOL, which also displayed good biocompatibility. These findings suggested that the GAT-loaded IOL could be a promising implant to prevent and cure POE, also the proposed methods could inspire more designs for various medical applications.http://www.sciencedirect.com/science/article/pii/S2452199X22002535PhotocuringDrug delivery intraocular lens3D printingPostoperative endophthalmitisGatifloxacin |
| spellingShingle | Mengna Li Jing-Wei Xu Jiayong Li Wei Wang Chenqi Luo Haijie Han Zhi-Kang Xu Ke Yao A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis Bioactive Materials Photocuring Drug delivery intraocular lens 3D printing Postoperative endophthalmitis Gatifloxacin |
| title | A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis |
| title_full | A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis |
| title_fullStr | A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis |
| title_full_unstemmed | A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis |
| title_short | A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis |
| title_sort | novel gatifloxacin loaded intraocular lens for prophylaxis of postoperative endophthalmitis |
| topic | Photocuring Drug delivery intraocular lens 3D printing Postoperative endophthalmitis Gatifloxacin |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22002535 |
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