Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review
Objectives: Visceral leishmaniasis remains a deadly parasitic disease with diagnostic complexities. Currently, point-of-care chest imaging is gaining momentum in the diagnosis of infectious diseases. Respiratory symptoms are common in visceral leishmaniasis. Here we aimed to systematically synthesiz...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-05-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121231177812 |
| _version_ | 1827938701972340736 |
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| author | Tesfahunegn Hailemariam Yonas Mebratu Tsion Andrias Fikremariam Melkeneh Abel Abebe Biruk Mulualem Zewdu Abadi Wazema Desta Selamawit Bedasso Fekadu Belay Abibual Sileshi Elilta Desta Felipe Velsaquez-Botero Rahel Birhane Francesco Marinucci Tsegahun Manyazewal |
| author_facet | Tesfahunegn Hailemariam Yonas Mebratu Tsion Andrias Fikremariam Melkeneh Abel Abebe Biruk Mulualem Zewdu Abadi Wazema Desta Selamawit Bedasso Fekadu Belay Abibual Sileshi Elilta Desta Felipe Velsaquez-Botero Rahel Birhane Francesco Marinucci Tsegahun Manyazewal |
| author_sort | Tesfahunegn Hailemariam |
| collection | DOAJ |
| description | Objectives: Visceral leishmaniasis remains a deadly parasitic disease with diagnostic complexities. Currently, point-of-care chest imaging is gaining momentum in the diagnosis of infectious diseases. Respiratory symptoms are common in visceral leishmaniasis. Here we aimed to systematically synthesize the evidence on the utility of chest imaging on the diagnosis and management of patients with visceral leishmaniasis. Methods: We searched PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar databases for studies reporting chest imaging findings in patients with visceral leishmaniasis, published in English from database inception to November 2022. We used the Joanna Briggs Institute checklists to evaluate the risk of bias. The protocol of this systematic review was registered with the Open Science Framework: https://doi.org/10.17605/OSF.IO/XP24W . Results: Of 1792 studies initially retrieved, 17 studies with 59 participants were included. Of the 59 patients, 51% (30) had respiratory symptoms and 20% (12) were human immunodeficiency virus co-infected. Chest X-ray, high-resolution computed tomography, and chest ultrasound findings were available for 95% (56), 93% (55), and 2% (1) of the patients, respectively. The most common findings were pleural effusion (20%; 12), reticular opacities (14%; 8), ground-glass opacities (12%; 7), and mediastinal lymphadenopathies (10%; 6). High-resolution computed tomography was more sensitive than chest X-ray and detected lesions that were lost on chest X-ray, 62% (37) versus 29% (17). In almost all cases, regression of the lesions was observed with treatment. Microscopy of pleural or lung biopsy detected amastigotes. Polymerase chain reaction yield was better in pleural and bronchoalveolar lavage fluids. A parasitological diagnosis from pleural and pericardial fluid was possible in AIDS patients. Overall, the risk of bias was low. Conclusions: Visceral leishmaniasis patients frequently had abnormal findings on high-resolution computed tomography. Chest ultrasound is a useful alternative in resource-limited settings to aid in diagnosis and subsequent treatment follow-up, especially when routine tests yield negative results despite clinical suspicion. |
| first_indexed | 2024-03-13T08:41:48Z |
| format | Article |
| id | doaj.art-2fe46a016f17463285ec8aa20df4ae4e |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-03-13T08:41:48Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-2fe46a016f17463285ec8aa20df4ae4e2023-05-30T09:04:31ZengSAGE PublishingSAGE Open Medicine2050-31212023-05-011110.1177/20503121231177812Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic reviewTesfahunegn Hailemariam0Yonas Mebratu1Tsion Andrias2Fikremariam Melkeneh3Abel Abebe4Biruk Mulualem5Zewdu Abadi6Wazema Desta7Selamawit Bedasso8Fekadu Belay9Abibual Sileshi10Elilta Desta11Felipe Velsaquez-Botero12Rahel Birhane13Francesco Marinucci14Tsegahun Manyazewal15Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaLondon School of Hygiene & Tropical Medicine, London, UKPrivate Hospitals Association, Addis Ababa, EthiopiaClinical Governance and Quality Improvement Unit, Teklehaimanot General Hospital, Addis Ababa, EthiopiaDetroit Medical Center/Wayne State University, Sinai Grace Hospital, Detroit, MI, USADepartment of Radiology, College of Medicine and Health Sciences, Bahir Dar University, Bahirdar, EthiopiaJinka General Hospital, Jinka, EthiopiaHealth Policy Department, Health Professionals Network for Tigray Takoma Park, MD, USAALERT Hospital/Armauer Hansen Research Institute, Addis Ababa, EthiopiaDepartment of Pediatrics and Child Health, College of Medicine and Health Sciences, Wachemo University, Hossana, EthiopiaInfectious Diseases Unit, Amdework Primary Hospital, Wag Hemra Zone, EthiopiaPark Pediatrics Clinic, Takoma Park, MD, USALarkin Community Hospital, CES University, Miami, FL, USACenter for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USACenter for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaObjectives: Visceral leishmaniasis remains a deadly parasitic disease with diagnostic complexities. Currently, point-of-care chest imaging is gaining momentum in the diagnosis of infectious diseases. Respiratory symptoms are common in visceral leishmaniasis. Here we aimed to systematically synthesize the evidence on the utility of chest imaging on the diagnosis and management of patients with visceral leishmaniasis. Methods: We searched PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar databases for studies reporting chest imaging findings in patients with visceral leishmaniasis, published in English from database inception to November 2022. We used the Joanna Briggs Institute checklists to evaluate the risk of bias. The protocol of this systematic review was registered with the Open Science Framework: https://doi.org/10.17605/OSF.IO/XP24W . Results: Of 1792 studies initially retrieved, 17 studies with 59 participants were included. Of the 59 patients, 51% (30) had respiratory symptoms and 20% (12) were human immunodeficiency virus co-infected. Chest X-ray, high-resolution computed tomography, and chest ultrasound findings were available for 95% (56), 93% (55), and 2% (1) of the patients, respectively. The most common findings were pleural effusion (20%; 12), reticular opacities (14%; 8), ground-glass opacities (12%; 7), and mediastinal lymphadenopathies (10%; 6). High-resolution computed tomography was more sensitive than chest X-ray and detected lesions that were lost on chest X-ray, 62% (37) versus 29% (17). In almost all cases, regression of the lesions was observed with treatment. Microscopy of pleural or lung biopsy detected amastigotes. Polymerase chain reaction yield was better in pleural and bronchoalveolar lavage fluids. A parasitological diagnosis from pleural and pericardial fluid was possible in AIDS patients. Overall, the risk of bias was low. Conclusions: Visceral leishmaniasis patients frequently had abnormal findings on high-resolution computed tomography. Chest ultrasound is a useful alternative in resource-limited settings to aid in diagnosis and subsequent treatment follow-up, especially when routine tests yield negative results despite clinical suspicion.https://doi.org/10.1177/20503121231177812 |
| spellingShingle | Tesfahunegn Hailemariam Yonas Mebratu Tsion Andrias Fikremariam Melkeneh Abel Abebe Biruk Mulualem Zewdu Abadi Wazema Desta Selamawit Bedasso Fekadu Belay Abibual Sileshi Elilta Desta Felipe Velsaquez-Botero Rahel Birhane Francesco Marinucci Tsegahun Manyazewal Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review SAGE Open Medicine |
| title | Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review |
| title_full | Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review |
| title_fullStr | Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review |
| title_full_unstemmed | Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review |
| title_short | Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review |
| title_sort | utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis a systematic review |
| url | https://doi.org/10.1177/20503121231177812 |
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