Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial
<b>Background:</b> While psychological difficulties, such as depression, among prostate cancer patients are known, their longitudinal burden remains understudied. We assessed the burden of depression across low-, intermediate- and high-risk prostate cancer groups, and the association bet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/7/2124 |
| _version_ | 1797608234594336768 |
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| author | Sumedha Chhatre Joseph J. Gallo Thomas Guzzo Knashawn H. Morales Diane K. Newman Neha Vapiwala Keith Van Arsdalen Alan J. Wein Stanley Bruce Malkowicz Ravishankar Jayadevappa |
| author_facet | Sumedha Chhatre Joseph J. Gallo Thomas Guzzo Knashawn H. Morales Diane K. Newman Neha Vapiwala Keith Van Arsdalen Alan J. Wein Stanley Bruce Malkowicz Ravishankar Jayadevappa |
| author_sort | Sumedha Chhatre |
| collection | DOAJ |
| description | <b>Background:</b> While psychological difficulties, such as depression, among prostate cancer patients are known, their longitudinal burden remains understudied. We assessed the burden of depression across low-, intermediate- and high-risk prostate cancer groups, and the association between regret and long-term depression. <b>Methods:</b> Secondary analysis of data from a multi-centered randomized controlled study among localized prostate cancer patients was carried out. Assessments were performed at baseline, and at 3-, 6-, 12- and 24-month follow-up. Depression was assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. A CES-D score ≥ 16 indicates high depression. Regret was measured using the regret scale of the Memorial Anxiety Scale for Prostate Cancer (MAX-PC). The proportion of patients with high depression was compared over time, for each risk category. Logistic regression was used to assess the association between regret, and long-term depression after adjusting for age, race, insurance, smoking status, marital status, income, education, employment, treatment, number of people in the household and study site. <b>Results:</b> The study had 743 localized prostate cancer patients. Median depression scores at 6, 12 and 24 months were significantly larger than the baseline median score, overall and for the three prostate cancer risk groups. The proportion of participants with high depression increased over time for all risk groups. Higher regret at 24-month follow-up was significantly associated with high depression at 24-month follow-up, after adjusting for covariates. <b>Conclusions:</b> A substantial proportion of localized prostate cancer patients continued to experience long-term depression. Patient-centered survivorship care strategies can help reduce depression and regret, and improve outcomes in prostate cancer care. |
| first_indexed | 2024-03-11T05:40:35Z |
| format | Article |
| id | doaj.art-2fe4ab9019e04198a98c3b11941798fe |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:40:35Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2fe4ab9019e04198a98c3b11941798fe2023-11-17T16:26:31ZengMDPI AGCancers2072-66942023-04-01157212410.3390/cancers15072124Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled TrialSumedha Chhatre0Joseph J. Gallo1Thomas Guzzo2Knashawn H. Morales3Diane K. Newman4Neha Vapiwala5Keith Van Arsdalen6Alan J. Wein7Stanley Bruce Malkowicz8Ravishankar Jayadevappa9Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USAUrology Division, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAUrology Division, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USACorporal Michael J. Crescenz VAMC, Philadelphia, PA 19104, USAUrology Division, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USACorporal Michael J. Crescenz VAMC, Philadelphia, PA 19104, USACorporal Michael J. Crescenz VAMC, Philadelphia, PA 19104, USA<b>Background:</b> While psychological difficulties, such as depression, among prostate cancer patients are known, their longitudinal burden remains understudied. We assessed the burden of depression across low-, intermediate- and high-risk prostate cancer groups, and the association between regret and long-term depression. <b>Methods:</b> Secondary analysis of data from a multi-centered randomized controlled study among localized prostate cancer patients was carried out. Assessments were performed at baseline, and at 3-, 6-, 12- and 24-month follow-up. Depression was assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. A CES-D score ≥ 16 indicates high depression. Regret was measured using the regret scale of the Memorial Anxiety Scale for Prostate Cancer (MAX-PC). The proportion of patients with high depression was compared over time, for each risk category. Logistic regression was used to assess the association between regret, and long-term depression after adjusting for age, race, insurance, smoking status, marital status, income, education, employment, treatment, number of people in the household and study site. <b>Results:</b> The study had 743 localized prostate cancer patients. Median depression scores at 6, 12 and 24 months were significantly larger than the baseline median score, overall and for the three prostate cancer risk groups. The proportion of participants with high depression increased over time for all risk groups. Higher regret at 24-month follow-up was significantly associated with high depression at 24-month follow-up, after adjusting for covariates. <b>Conclusions:</b> A substantial proportion of localized prostate cancer patients continued to experience long-term depression. Patient-centered survivorship care strategies can help reduce depression and regret, and improve outcomes in prostate cancer care.https://www.mdpi.com/2072-6694/15/7/2124localized prostate cancerprostate cancer risk groupsdepressiondecision regretlongitudinal assessment |
| spellingShingle | Sumedha Chhatre Joseph J. Gallo Thomas Guzzo Knashawn H. Morales Diane K. Newman Neha Vapiwala Keith Van Arsdalen Alan J. Wein Stanley Bruce Malkowicz Ravishankar Jayadevappa Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial Cancers localized prostate cancer prostate cancer risk groups depression decision regret longitudinal assessment |
| title | Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial |
| title_full | Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial |
| title_fullStr | Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial |
| title_full_unstemmed | Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial |
| title_short | Trajectory of Depression among Prostate Cancer Patients: A Secondary Analysis of a Randomized Controlled Trial |
| title_sort | trajectory of depression among prostate cancer patients a secondary analysis of a randomized controlled trial |
| topic | localized prostate cancer prostate cancer risk groups depression decision regret longitudinal assessment |
| url | https://www.mdpi.com/2072-6694/15/7/2124 |
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