Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation

Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation

SiO<sub>2</sub>–SO<sub>3</sub>H, with a surface area of 115 m<sup>2</sup>/g and pore volume of 0.38 cm<sup>3</sup>g<sup>−1</sup>, and 1.32 mmol H<sup>+</sup>/g was used as a 20% <i>w</i>/<i>w</i> catalyst...

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Bibliographic Details
Main Authors: Sandro L. Barbosa, David Lee Nelson, Milton de S. Freitas, Wallans Torres Pio dos Santos, Stanlei I. Klein, Giuliano C. Clososki, Franco J. Caires, Alexandre P. Wentz
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
sulfonated silica catalyst (SiO<sub>2</sub>–SO<sub>3</sub>H)
methyl salicylate
green chemistry
methylating agent
deacetylation (acyl nucleophilic substitution)
solid acid catalyst
Online Access:https://www.mdpi.com/1420-3049/27/15/4767
Description
Summary:SiO<sub>2</sub>–SO<sub>3</sub>H, with a surface area of 115 m<sup>2</sup>/g and pore volume of 0.38 cm<sup>3</sup>g<sup>−1</sup>, and 1.32 mmol H<sup>+</sup>/g was used as a 20% <i>w</i>/<i>w</i> catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times.
ISSN:1420-3049

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