Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genotoxic stress. The selective radioprotection of non-...

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Bibliographic Details
Main Authors: Sukhbir Kaur, Anthony L. Schwartz, David G. Jordan, David R. Soto-Pantoja, Bethany Kuo, Abdel G. Elkahloun, Lesley Mathews Griner, Craig J. Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N. Rajapakse, Yves Pommier, David D. Roberts
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
radioresistance
epigenetics
CD47
thrombospondin-1
DNA damage response
schlafen-11
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00994/full

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