Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort
Counselling and genetic testing (CGT) after neonatal screening may increase depression and anxiety (DA) levels during cancer surveillance. This study assessed the DA scores in mothers of newborns from Paraná state, Southern Brazil, carrying the <i>TP53</i> p.R337H variant. To understand...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/12/2945 |
| _version_ | 1797489113535873024 |
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| author | Amanda Scartezini Gozdziejewski Clarice Wichinescki Zotti Isabela Aparecida Moreira de Carvalho Thairine Camargo dos Santos Luana Rayana de Santi Walter Karin Rosa Persegona Ogradowski Karin Luiza Dammski Heloisa Komechen Monalisa Castilho Mendes Emanuelle Nunes de Souza Mariana Martins Paraizo Ivy Zortea da Silva Parise Guilherme Augusto Parise André Luiz Grion Gislaine Custódio Rosiane Guetter Mello Bonald C. Figueiredo |
| author_facet | Amanda Scartezini Gozdziejewski Clarice Wichinescki Zotti Isabela Aparecida Moreira de Carvalho Thairine Camargo dos Santos Luana Rayana de Santi Walter Karin Rosa Persegona Ogradowski Karin Luiza Dammski Heloisa Komechen Monalisa Castilho Mendes Emanuelle Nunes de Souza Mariana Martins Paraizo Ivy Zortea da Silva Parise Guilherme Augusto Parise André Luiz Grion Gislaine Custódio Rosiane Guetter Mello Bonald C. Figueiredo |
| author_sort | Amanda Scartezini Gozdziejewski |
| collection | DOAJ |
| description | Counselling and genetic testing (CGT) after neonatal screening may increase depression and anxiety (DA) levels during cancer surveillance. This study assessed the DA scores in mothers of newborns from Paraná state, Southern Brazil, carrying the <i>TP53</i> p.R337H variant. To understand and adjust DA conditions during term of pregnancy, we initially detected sociodemographic covariates [marital status (MS), number of children (NC), and/or education level (EL): MS-NC-EL] on an independent group of pregnant women (not subjected to genetic testing). The Hospital Anxiety and Depression Scale (HADS) was used to assess risk factors in pregnant (cross-sectional analysis) and unrelated mothers (at 2-month intervals, longitudinal study) of <i>TP53</i> p.R337H-tested newborns (three sessions of HADS analysis) using Wilcoxon (Mann–Whitney) and Kruskal–Wallis nonparametric tests. Lower anxiety levels were observed in mothers of noncarriers (without MS-NC-EL = 6.91 ± 1.19; with MS-NC-EL = 6.82 ± 0.93) than in mothers of p.R337H carriers in the first session (without MS-NC-EL = 6.82 = 8.49 ± 0.6025, with MS-NC-EL = 6.82 = 9.21 ± 0.66). The anxiety levels significantly decreased 4 months after CGT (third session) in mothers of p.R337H carriers. We did not find a significant change in depression scores. Mothers with mental health instability requiring medications need periodical psychological support during and after CGT. |
| first_indexed | 2024-03-10T00:12:51Z |
| format | Article |
| id | doaj.art-2fe922f67d474663a234f3926e6d02cc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:12:51Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2fe922f67d474663a234f3926e6d02cc2023-11-23T15:56:53ZengMDPI AGCancers2072-66942022-06-011412294510.3390/cancers14122945Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance CohortAmanda Scartezini Gozdziejewski0Clarice Wichinescki Zotti1Isabela Aparecida Moreira de Carvalho2Thairine Camargo dos Santos3Luana Rayana de Santi Walter4Karin Rosa Persegona Ogradowski5Karin Luiza Dammski6Heloisa Komechen7Monalisa Castilho Mendes8Emanuelle Nunes de Souza9Mariana Martins Paraizo10Ivy Zortea da Silva Parise11Guilherme Augusto Parise12André Luiz Grion13Gislaine Custódio14Rosiane Guetter Mello15Bonald C. Figueiredo16Pelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilFaculdades Pequeno Príncipe, 333 Iguaçu Av., Rebouças, Curitiba 80230-902, PR, BrazilFaculdades Pequeno Príncipe, 333 Iguaçu Av., Rebouças, Curitiba 80230-902, PR, BrazilFaculdades Pequeno Príncipe, 333 Iguaçu Av., Rebouças, Curitiba 80230-902, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilCentro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC), UFPR, 400 Agostinho Leão Jr. Av., Curitiba 80030-110, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilPelé Pequeno Príncipe Research Institute, 1532 Silva Jardim, AV., Curitiba 80250-200, PR, BrazilCounselling and genetic testing (CGT) after neonatal screening may increase depression and anxiety (DA) levels during cancer surveillance. This study assessed the DA scores in mothers of newborns from Paraná state, Southern Brazil, carrying the <i>TP53</i> p.R337H variant. To understand and adjust DA conditions during term of pregnancy, we initially detected sociodemographic covariates [marital status (MS), number of children (NC), and/or education level (EL): MS-NC-EL] on an independent group of pregnant women (not subjected to genetic testing). The Hospital Anxiety and Depression Scale (HADS) was used to assess risk factors in pregnant (cross-sectional analysis) and unrelated mothers (at 2-month intervals, longitudinal study) of <i>TP53</i> p.R337H-tested newborns (three sessions of HADS analysis) using Wilcoxon (Mann–Whitney) and Kruskal–Wallis nonparametric tests. Lower anxiety levels were observed in mothers of noncarriers (without MS-NC-EL = 6.91 ± 1.19; with MS-NC-EL = 6.82 ± 0.93) than in mothers of p.R337H carriers in the first session (without MS-NC-EL = 6.82 = 8.49 ± 0.6025, with MS-NC-EL = 6.82 = 9.21 ± 0.66). The anxiety levels significantly decreased 4 months after CGT (third session) in mothers of p.R337H carriers. We did not find a significant change in depression scores. Mothers with mental health instability requiring medications need periodical psychological support during and after CGT.https://www.mdpi.com/2072-6694/14/12/2945<i>TP53</i> p.R337H mutationpredictive testinggenetic counsellinganxietydepression |
| spellingShingle | Amanda Scartezini Gozdziejewski Clarice Wichinescki Zotti Isabela Aparecida Moreira de Carvalho Thairine Camargo dos Santos Luana Rayana de Santi Walter Karin Rosa Persegona Ogradowski Karin Luiza Dammski Heloisa Komechen Monalisa Castilho Mendes Emanuelle Nunes de Souza Mariana Martins Paraizo Ivy Zortea da Silva Parise Guilherme Augusto Parise André Luiz Grion Gislaine Custódio Rosiane Guetter Mello Bonald C. Figueiredo Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort Cancers <i>TP53</i> p.R337H mutation predictive testing genetic counselling anxiety depression |
| title | Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort |
| title_full | Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort |
| title_fullStr | Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort |
| title_full_unstemmed | Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort |
| title_short | Psychological Impact of <i>TP53</i>-Variant-Carrier Newborns and Counselling on Mothers: A Pediatric Surveillance Cohort |
| title_sort | psychological impact of i tp53 i variant carrier newborns and counselling on mothers a pediatric surveillance cohort |
| topic | <i>TP53</i> p.R337H mutation predictive testing genetic counselling anxiety depression |
| url | https://www.mdpi.com/2072-6694/14/12/2945 |
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