Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis
BackgroundHidradenitis suppurativa were associated with comorbidities in various organ systems. Inflammatory dermatological diseases such as pyoderma gangrenosum were reported to be associated with hidradenitis suppurativa. Nevertheless, as for the association between hidradenitis suppurativa and ps...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1033844/full |
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| author | Shuo-Yan Gau Shuo-Yan Gau Ivan Arni C. Preclaro Ivan Arni C. Preclaro James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Chien-Ying Lee Chien-Ying Lee Yu-Hsiang Kuan Yu-Hsiang Kuan Yu-Ping Hsiao Yu-Ping Hsiao Sin-Ei Juang Kevin Sheng-Kai Ma Kevin Sheng-Kai Ma Kevin Sheng-Kai Ma |
| author_facet | Shuo-Yan Gau Shuo-Yan Gau Ivan Arni C. Preclaro Ivan Arni C. Preclaro James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Chien-Ying Lee Chien-Ying Lee Yu-Hsiang Kuan Yu-Hsiang Kuan Yu-Ping Hsiao Yu-Ping Hsiao Sin-Ei Juang Kevin Sheng-Kai Ma Kevin Sheng-Kai Ma Kevin Sheng-Kai Ma |
| author_sort | Shuo-Yan Gau |
| collection | DOAJ |
| description | BackgroundHidradenitis suppurativa were associated with comorbidities in various organ systems. Inflammatory dermatological diseases such as pyoderma gangrenosum were reported to be associated with hidradenitis suppurativa. Nevertheless, as for the association between hidradenitis suppurativa and psoriasis, evidences were insufficient. In many studies, the association between psoriasis and hidradenitis suppurativa has been reported. However, some evidence seems to be controversial. The purpose of the systematic review and meta-analysis was to assess whether there was significant association between HS and psoriasis.MethodsOn June 01, 2022, we appraised 2,795 articles from databases including PubMed, Web of Science and Embase. Search syntaxes were based on ‘hidradenitis suppurativa’ or ‘acne inversa’ with “psoriasis”, “comorbidities” or ‘epidemiology’. Synonyms were determined based on MeSH terms and Emtree. Observational results that evaluated the odds ratio for people with hidradenitis suppurativa who had psoriasis were extracted for qualitative synthesis.ResultsAfter the selection process of the initial 2,795 studies, ten observational studies, including 3 cohort studies, 1 case-control study, and 6 cross-sectional studies, were extracted for critical appraisal. Based on the integration of 7 studies (with more than 560,000 participants included), people with hidradenitis suppurativa had a higher risk of having psoriasis, with a 2.67-fold risk (95% CI, 1.84, 3.87). The association remained in the sensitivity analyses utilizing strict adjustment models. In the analysis that only included studies with a similar study design and adjustments in obesity-related factors, the risk of people with hidradenitis suppurativa having psoriasis was 3.24 (95% CI, 2.27, 4.62). In male patients with HS, the risk of having psoriasis was 4.30-fold higher than male patients without HS (95% CI, 2.37, 7.78). Likewise, in an analysis including 3 cross-sectional studies, the risk of female HS patients having psoriasis was 3.94-fold higher than female HS-free patients (95% CI, 2.34, 6.63).ConclusionsThe co-occurrence of hidradenitis suppurativa and psoriasis can greatly increase the burden of the disease. Psoriasis could be one of the critical comorbidities of hidradenitis suppurativa and should be recommended for future screening and follow up. The association between the two diseases should be kept in mind in managing hidradenitis suppurativa patients. More prospective studies are needed to establish the true magnitude of the association between psoriasis and hidradenitis suppurativa. |
| first_indexed | 2024-04-13T13:18:12Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T13:18:12Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2fe9f2bda3614a4b96a9d9c456d914712022-12-22T02:45:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10338441033844Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysisShuo-Yan Gau0Shuo-Yan Gau1Ivan Arni C. Preclaro2Ivan Arni C. Preclaro3James Cheng-Chung Wei4James Cheng-Chung Wei5James Cheng-Chung Wei6Chien-Ying Lee7Chien-Ying Lee8Yu-Hsiang Kuan9Yu-Hsiang Kuan10Yu-Ping Hsiao11Yu-Ping Hsiao12Sin-Ei Juang13Kevin Sheng-Kai Ma14Kevin Sheng-Kai Ma15Kevin Sheng-Kai Ma16School of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Medical Education, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital, Taoyuan, TaiwanDrug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, TaiwanGraduate Institute of Integrated Medicine, China Medical University, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Pharmacology, Chung Shan Medical University, Taichung, TaiwanDepartment of Pharmacy, Chung Shan Medical University Hospital, Taichung, TaiwanDepartment of Pharmacology, Chung Shan Medical University, Taichung, TaiwanDepartment of Pharmacy, Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan0Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan1Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan2Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States3Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States4Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesBackgroundHidradenitis suppurativa were associated with comorbidities in various organ systems. Inflammatory dermatological diseases such as pyoderma gangrenosum were reported to be associated with hidradenitis suppurativa. Nevertheless, as for the association between hidradenitis suppurativa and psoriasis, evidences were insufficient. In many studies, the association between psoriasis and hidradenitis suppurativa has been reported. However, some evidence seems to be controversial. The purpose of the systematic review and meta-analysis was to assess whether there was significant association between HS and psoriasis.MethodsOn June 01, 2022, we appraised 2,795 articles from databases including PubMed, Web of Science and Embase. Search syntaxes were based on ‘hidradenitis suppurativa’ or ‘acne inversa’ with “psoriasis”, “comorbidities” or ‘epidemiology’. Synonyms were determined based on MeSH terms and Emtree. Observational results that evaluated the odds ratio for people with hidradenitis suppurativa who had psoriasis were extracted for qualitative synthesis.ResultsAfter the selection process of the initial 2,795 studies, ten observational studies, including 3 cohort studies, 1 case-control study, and 6 cross-sectional studies, were extracted for critical appraisal. Based on the integration of 7 studies (with more than 560,000 participants included), people with hidradenitis suppurativa had a higher risk of having psoriasis, with a 2.67-fold risk (95% CI, 1.84, 3.87). The association remained in the sensitivity analyses utilizing strict adjustment models. In the analysis that only included studies with a similar study design and adjustments in obesity-related factors, the risk of people with hidradenitis suppurativa having psoriasis was 3.24 (95% CI, 2.27, 4.62). In male patients with HS, the risk of having psoriasis was 4.30-fold higher than male patients without HS (95% CI, 2.37, 7.78). Likewise, in an analysis including 3 cross-sectional studies, the risk of female HS patients having psoriasis was 3.94-fold higher than female HS-free patients (95% CI, 2.34, 6.63).ConclusionsThe co-occurrence of hidradenitis suppurativa and psoriasis can greatly increase the burden of the disease. Psoriasis could be one of the critical comorbidities of hidradenitis suppurativa and should be recommended for future screening and follow up. The association between the two diseases should be kept in mind in managing hidradenitis suppurativa patients. More prospective studies are needed to establish the true magnitude of the association between psoriasis and hidradenitis suppurativa.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1033844/fullhidradenitis suppurativapsoriasismeta-analysisepidemiologyimmunology |
| spellingShingle | Shuo-Yan Gau Shuo-Yan Gau Ivan Arni C. Preclaro Ivan Arni C. Preclaro James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Chien-Ying Lee Chien-Ying Lee Yu-Hsiang Kuan Yu-Hsiang Kuan Yu-Ping Hsiao Yu-Ping Hsiao Sin-Ei Juang Kevin Sheng-Kai Ma Kevin Sheng-Kai Ma Kevin Sheng-Kai Ma Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis Frontiers in Immunology hidradenitis suppurativa psoriasis meta-analysis epidemiology immunology |
| title | Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis |
| title_full | Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis |
| title_fullStr | Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis |
| title_full_unstemmed | Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis |
| title_short | Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis |
| title_sort | risk of psoriasis in people with hidradenitis suppurativa a systematic review and meta analysis |
| topic | hidradenitis suppurativa psoriasis meta-analysis epidemiology immunology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1033844/full |
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