Aptamer-Based Sensors for Thrombin Detection Application
Thrombin facilitates the aggregation of platelet in hemostatic processes and participates in the regulation of cell signaling. Therefore, the development of thrombin sensors is conducive to comprehending the role of thrombin in the course of a disease. Biosensors based on aptamers screened by SELEX...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/10/7/255 |
| _version_ | 1797406961157799936 |
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| author | Hongzhi Sun Nannan Wang Lin Zhang Hongmin Meng Zhaohui Li |
| author_facet | Hongzhi Sun Nannan Wang Lin Zhang Hongmin Meng Zhaohui Li |
| author_sort | Hongzhi Sun |
| collection | DOAJ |
| description | Thrombin facilitates the aggregation of platelet in hemostatic processes and participates in the regulation of cell signaling. Therefore, the development of thrombin sensors is conducive to comprehending the role of thrombin in the course of a disease. Biosensors based on aptamers screened by SELEX have exhibited superiority for thrombin detection. In this review, we summarized the aptamer-based sensors for thrombin detection which rely on the specific recognitions between thrombin and aptamer. Meanwhile, the unique advantages of different sensors including optical and electrochemical sensors were also highlighted. Especially, these sensors based on electrochemistry have the potential to be miniaturized, and thus have gained comprehensive attention. Furthermore, concerns about aptamer-based sensors for thrombin detection, prospects of the future and promising avenues in this field were also presented. |
| first_indexed | 2024-03-09T03:34:21Z |
| format | Article |
| id | doaj.art-2fea93f15e234a3fbb3db3e86e91b8fd |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-09T03:34:21Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-2fea93f15e234a3fbb3db3e86e91b8fd2023-12-03T14:50:20ZengMDPI AGChemosensors2227-90402022-06-0110725510.3390/chemosensors10070255Aptamer-Based Sensors for Thrombin Detection ApplicationHongzhi Sun0Nannan Wang1Lin Zhang2Hongmin Meng3Zhaohui Li4Key Laboratory of Functional Nanomaterial and Medical Theranostics, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, College of Chemistry, Institute of Analytical Chemistry for Life Science, Zhengzhou University, Zhengzhou 450001, ChinaOffice of Linshu County, Linyi Ecological Environmental Bureau, Linyi 276700, ChinaKey Laboratory of Functional Nanomaterial and Medical Theranostics, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, College of Chemistry, Institute of Analytical Chemistry for Life Science, Zhengzhou University, Zhengzhou 450001, ChinaKey Laboratory of Functional Nanomaterial and Medical Theranostics, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, College of Chemistry, Institute of Analytical Chemistry for Life Science, Zhengzhou University, Zhengzhou 450001, ChinaKey Laboratory of Functional Nanomaterial and Medical Theranostics, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, College of Chemistry, Institute of Analytical Chemistry for Life Science, Zhengzhou University, Zhengzhou 450001, ChinaThrombin facilitates the aggregation of platelet in hemostatic processes and participates in the regulation of cell signaling. Therefore, the development of thrombin sensors is conducive to comprehending the role of thrombin in the course of a disease. Biosensors based on aptamers screened by SELEX have exhibited superiority for thrombin detection. In this review, we summarized the aptamer-based sensors for thrombin detection which rely on the specific recognitions between thrombin and aptamer. Meanwhile, the unique advantages of different sensors including optical and electrochemical sensors were also highlighted. Especially, these sensors based on electrochemistry have the potential to be miniaturized, and thus have gained comprehensive attention. Furthermore, concerns about aptamer-based sensors for thrombin detection, prospects of the future and promising avenues in this field were also presented.https://www.mdpi.com/2227-9040/10/7/255thrombinaptameroptical sensorelectrochemical sensor |
| spellingShingle | Hongzhi Sun Nannan Wang Lin Zhang Hongmin Meng Zhaohui Li Aptamer-Based Sensors for Thrombin Detection Application Chemosensors thrombin aptamer optical sensor electrochemical sensor |
| title | Aptamer-Based Sensors for Thrombin Detection Application |
| title_full | Aptamer-Based Sensors for Thrombin Detection Application |
| title_fullStr | Aptamer-Based Sensors for Thrombin Detection Application |
| title_full_unstemmed | Aptamer-Based Sensors for Thrombin Detection Application |
| title_short | Aptamer-Based Sensors for Thrombin Detection Application |
| title_sort | aptamer based sensors for thrombin detection application |
| topic | thrombin aptamer optical sensor electrochemical sensor |
| url | https://www.mdpi.com/2227-9040/10/7/255 |
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