Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India
Context: It is postulated that 25(OH)D deficiency is associated with a worse prognosis of COVID-19. Aims: We aimed to find out whether baseline serum 25-hydroxy vitamin D levels were correlated with COVID-19 disease severity or not in Indian population. Settings and Design: It is a prospective obser...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=2;spage=170;epage=176;aulast=Sanamandra |
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| author | Prudwiraj Sanamandra Jugal V Gada Sukirti Misra Sagar A Barasara Premlata K Varthakavi Nikhil M Bhagwat |
| author_facet | Prudwiraj Sanamandra Jugal V Gada Sukirti Misra Sagar A Barasara Premlata K Varthakavi Nikhil M Bhagwat |
| author_sort | Prudwiraj Sanamandra |
| collection | DOAJ |
| description | Context: It is postulated that 25(OH)D deficiency is associated with a worse prognosis of COVID-19. Aims: We aimed to find out whether baseline serum 25-hydroxy vitamin D levels were correlated with COVID-19 disease severity or not in Indian population. Settings and Design: It is a prospective observational study. Methods and Material: We prospectively recruited 200 COVID-19-positive adult patients and measured their baseline vitamin D levels on admission and prospectively followed their clinical course for their outcome and correlated the association. Statistical Analysis Used: The continuous data were represented as mean (±SD) or median (IQR), while the categorical data were represented as proportions. Parametric data were analysed using unpaired T-test and ANOVA for two and more than two groups, and for categorical, nonparametric data, Chi-square test were applied. A two-sided P value of <0.05 was considered as statistically significant with 95% confidence interval. Results: Eighty-six per cent (172/200) of patients had hypovitaminosis D (<30 ng/mL). The prevalence of 25(OH) severe deficiency, deficiency and vitamin D insufficiency was 23%, 41% and 22%, respectively. Clinical severity was graded as asymptomatic (11%), mild (14%), moderate (14.5%), severe (37.5%) and critical (22%). Sixty per cent of patients had clinically severe or critical disease requiring oxygen support with eleven per cent (n = 22) mortality overall. Age (P: 0.001), HTN (P: 0.049) and DM (P: 0.018) were negatively associated with clinical severity. No linear association was found between vitamin D levels and clinical severity. Low vitamin D levels had a significant inverse association with inflammatory markers like neutrophil–lymphocyte ratio (NLR, P: 0.012) and IL-6 (P: 0.002). Conclusions: Vitamin D deficiency was not associated with worse outcomes of COVID-19 infection in Indian population. |
| first_indexed | 2024-03-13T10:36:47Z |
| format | Article |
| id | doaj.art-2feda5591c264ae4898911db1fc38b83 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-03-13T10:36:47Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-2feda5591c264ae4898911db1fc38b832023-05-18T05:47:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102023-01-0127217017610.4103/ijem.ijem_383_22Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western IndiaPrudwiraj SanamandraJugal V GadaSukirti MisraSagar A BarasaraPremlata K VarthakaviNikhil M BhagwatContext: It is postulated that 25(OH)D deficiency is associated with a worse prognosis of COVID-19. Aims: We aimed to find out whether baseline serum 25-hydroxy vitamin D levels were correlated with COVID-19 disease severity or not in Indian population. Settings and Design: It is a prospective observational study. Methods and Material: We prospectively recruited 200 COVID-19-positive adult patients and measured their baseline vitamin D levels on admission and prospectively followed their clinical course for their outcome and correlated the association. Statistical Analysis Used: The continuous data were represented as mean (±SD) or median (IQR), while the categorical data were represented as proportions. Parametric data were analysed using unpaired T-test and ANOVA for two and more than two groups, and for categorical, nonparametric data, Chi-square test were applied. A two-sided P value of <0.05 was considered as statistically significant with 95% confidence interval. Results: Eighty-six per cent (172/200) of patients had hypovitaminosis D (<30 ng/mL). The prevalence of 25(OH) severe deficiency, deficiency and vitamin D insufficiency was 23%, 41% and 22%, respectively. Clinical severity was graded as asymptomatic (11%), mild (14%), moderate (14.5%), severe (37.5%) and critical (22%). Sixty per cent of patients had clinically severe or critical disease requiring oxygen support with eleven per cent (n = 22) mortality overall. Age (P: 0.001), HTN (P: 0.049) and DM (P: 0.018) were negatively associated with clinical severity. No linear association was found between vitamin D levels and clinical severity. Low vitamin D levels had a significant inverse association with inflammatory markers like neutrophil–lymphocyte ratio (NLR, P: 0.012) and IL-6 (P: 0.002). Conclusions: Vitamin D deficiency was not associated with worse outcomes of COVID-19 infection in Indian population.http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=2;spage=170;epage=176;aulast=Sanamandracovid-19inflammationneutrophil–lymphocyte ratiovitamin d deficiency |
| spellingShingle | Prudwiraj Sanamandra Jugal V Gada Sukirti Misra Sagar A Barasara Premlata K Varthakavi Nikhil M Bhagwat Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India Indian Journal of Endocrinology and Metabolism covid-19 inflammation neutrophil–lymphocyte ratio vitamin d deficiency |
| title | Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India |
| title_full | Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India |
| title_fullStr | Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India |
| title_full_unstemmed | Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India |
| title_short | Correlation between Serum Vitamin D3 levels and severity of COVID-19, experience from a COVID-19-dedicated tertiary care hospital from Western India |
| title_sort | correlation between serum vitamin d3 levels and severity of covid 19 experience from a covid 19 dedicated tertiary care hospital from western india |
| topic | covid-19 inflammation neutrophil–lymphocyte ratio vitamin d deficiency |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=2;spage=170;epage=176;aulast=Sanamandra |
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