Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach
The worldwide scenario of antibiotic resistance and the falling number of funds for the development of novel antibiotics have led research efforts toward the study of specific cost-effective strategies aimed at discovering drugs against microbial infections. Among the potential options, drug reposit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/6/816 |
| _version_ | 1827662887095631872 |
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| author | Alexia Barbarossa Antonio Rosato Filomena Corbo Maria Lisa Clodoveo Giuseppe Fracchiolla Antonio Carrieri Alessia Carocci |
| author_facet | Alexia Barbarossa Antonio Rosato Filomena Corbo Maria Lisa Clodoveo Giuseppe Fracchiolla Antonio Carrieri Alessia Carocci |
| author_sort | Alexia Barbarossa |
| collection | DOAJ |
| description | The worldwide scenario of antibiotic resistance and the falling number of funds for the development of novel antibiotics have led research efforts toward the study of specific cost-effective strategies aimed at discovering drugs against microbial infections. Among the potential options, drug repositioning, which has already exhibited satisfactory results in other medical fields, came out as the most promising. It consists of finding new uses for previously approved medicines and, over the years, many “repurposed drugs” displayed some encouraging in vitro and in vivo results beyond their initial application. The principal theoretical justification for reusing already existing drugs is that they have known mechanisms of action and manageable side effects. Reuse of old drugs is now considered an interesting approach to overcome the drawbacks of conventional antibiotics. The purpose of this review is to offer the reader a panoramic view of the updated studies concerning the repositioning process of different classes of non-antibiotic drugs in the antimicrobial field. Several research works reported the ability of some non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants, antipsychotics, and statins to counteract the growth of harmful microorganisms, demonstrating an interesting winning mode to fight infectious diseases caused by antimicrobial resistant bacteria. |
| first_indexed | 2024-03-10T00:35:10Z |
| format | Article |
| id | doaj.art-2fee8d5f556a435aa52aae4898cbc0b7 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T00:35:10Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-2fee8d5f556a435aa52aae4898cbc0b72023-11-23T15:17:49ZengMDPI AGAntibiotics2079-63822022-06-0111681610.3390/antibiotics11060816Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial ApproachAlexia Barbarossa0Antonio Rosato1Filomena Corbo2Maria Lisa Clodoveo3Giuseppe Fracchiolla4Antonio Carrieri5Alessia Carocci6Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyInterdisciplinary Department of Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyThe worldwide scenario of antibiotic resistance and the falling number of funds for the development of novel antibiotics have led research efforts toward the study of specific cost-effective strategies aimed at discovering drugs against microbial infections. Among the potential options, drug repositioning, which has already exhibited satisfactory results in other medical fields, came out as the most promising. It consists of finding new uses for previously approved medicines and, over the years, many “repurposed drugs” displayed some encouraging in vitro and in vivo results beyond their initial application. The principal theoretical justification for reusing already existing drugs is that they have known mechanisms of action and manageable side effects. Reuse of old drugs is now considered an interesting approach to overcome the drawbacks of conventional antibiotics. The purpose of this review is to offer the reader a panoramic view of the updated studies concerning the repositioning process of different classes of non-antibiotic drugs in the antimicrobial field. Several research works reported the ability of some non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants, antipsychotics, and statins to counteract the growth of harmful microorganisms, demonstrating an interesting winning mode to fight infectious diseases caused by antimicrobial resistant bacteria.https://www.mdpi.com/2079-6382/11/6/816antibacterial activityantifungal activitynon-antibiotic agentsantimicrobial resistancerepositioning |
| spellingShingle | Alexia Barbarossa Antonio Rosato Filomena Corbo Maria Lisa Clodoveo Giuseppe Fracchiolla Antonio Carrieri Alessia Carocci Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach Antibiotics antibacterial activity antifungal activity non-antibiotic agents antimicrobial resistance repositioning |
| title | Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach |
| title_full | Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach |
| title_fullStr | Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach |
| title_full_unstemmed | Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach |
| title_short | Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach |
| title_sort | non antibiotic drug repositioning as an alternative antimicrobial approach |
| topic | antibacterial activity antifungal activity non-antibiotic agents antimicrobial resistance repositioning |
| url | https://www.mdpi.com/2079-6382/11/6/816 |
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