Species-Specificity of Transcriptional Regulation and the Response to Lipopolysaccharide in Mammalian Macrophages

Species-Specificity of Transcriptional Regulation and the Response to Lipopolysaccharide in Mammalian Macrophages

Mammalian macrophages differ in their basal gene expression profiles and response to the toll-like receptor 4 (TLR4) agonist, lipopolysaccharide (LPS). In human macrophages, LPS elicits a temporal cascade of transient gene expression including feed forward activators and feedback regulators that lim...

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Bibliographic Details
Main Authors: Stephen J. Bush, Mary E. B. McCulloch, Zofia M. Lisowski, Charity Muriuki, Emily L. Clark, Rachel Young, Clare Pridans, James G. D. Prendergast, Kim M. Summers, David A. Hume
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transcriptome
macrophage
LPS
feedback
network
conservation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00661/full

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