Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances
Breast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natura...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.990145/full |
| _version_ | 1817999531641405440 |
|---|---|
| author | Yufeng Jia Siwen Chen Siwen Chen Chenyu Wang Tao Sun Liqun Yang |
| author_facet | Yufeng Jia Siwen Chen Siwen Chen Chenyu Wang Tao Sun Liqun Yang |
| author_sort | Yufeng Jia |
| collection | DOAJ |
| description | Breast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natural polymers are attracting extensive interest as drug carriers in treating breast cancer. Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility, biodegradability, and non-immunogenicity and is a significant component of the extracellular matrix. The CD44 receptor of HA is overexpressed in breast cancer cells and can be targeted to breast tumors. Therefore, many researchers have developed nano drug delivery systems (NDDS) based on the CD44 receptor tumor-targeting properties of HA. This review examines the application of HA in NDDSs for breast cancer in recent years. Based on the structural composition of NDDSs, they are divided into HA NDDSs, Modified HA NDDSs, and HA hybrid NDDSs. |
| first_indexed | 2024-04-14T03:10:07Z |
| format | Article |
| id | doaj.art-2fef6785e75a4ad3a5fc0223250e63b9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-14T03:10:07Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-2fef6785e75a4ad3a5fc0223250e63b92022-12-22T02:15:37ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.990145990145Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advancesYufeng Jia0Siwen Chen1Siwen Chen2Chenyu Wang3Tao Sun4Liqun Yang5Department of Breast Medicine, Liaoning Cancer Hospital, Cancer Hospital of China Medical University, Shenyang, ChinaCenter for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics (China Medical University), Liaoning Research Institute of Family Planning (The Reproductive Hospital of China Medical University), Shenyang, ChinaDepartment of Information Management, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, ChinaDepartment of Breast Medicine, Liaoning Cancer Hospital, Cancer Hospital of China Medical University, Shenyang, ChinaNHC Key Laboratory of Reproductive Health and Medical Genetics (China Medical University), Liaoning Research Institute of Family Planning (The Reproductive Hospital of China Medical University), Shenyang, ChinaBreast cancer (BC) is the most common malignancy among females worldwide, and high resistance to drugs and metastasis rates are the leading causes of death in BC patients. Releasing anti-cancer drugs precisely to the tumor site can improve the efficacy and reduce the side effects on the body. Natural polymers are attracting extensive interest as drug carriers in treating breast cancer. Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility, biodegradability, and non-immunogenicity and is a significant component of the extracellular matrix. The CD44 receptor of HA is overexpressed in breast cancer cells and can be targeted to breast tumors. Therefore, many researchers have developed nano drug delivery systems (NDDS) based on the CD44 receptor tumor-targeting properties of HA. This review examines the application of HA in NDDSs for breast cancer in recent years. Based on the structural composition of NDDSs, they are divided into HA NDDSs, Modified HA NDDSs, and HA hybrid NDDSs.https://www.frontiersin.org/articles/10.3389/fbioe.2022.990145/fullhyaluronic acidbreast canceranticancer drugsnanoparticlesdrug delivery system (DDS) |
| spellingShingle | Yufeng Jia Siwen Chen Siwen Chen Chenyu Wang Tao Sun Liqun Yang Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances Frontiers in Bioengineering and Biotechnology hyaluronic acid breast cancer anticancer drugs nanoparticles drug delivery system (DDS) |
| title | Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances |
| title_full | Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances |
| title_fullStr | Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances |
| title_full_unstemmed | Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances |
| title_short | Hyaluronic acid-based nano drug delivery systems for breast cancer treatment: Recent advances |
| title_sort | hyaluronic acid based nano drug delivery systems for breast cancer treatment recent advances |
| topic | hyaluronic acid breast cancer anticancer drugs nanoparticles drug delivery system (DDS) |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.990145/full |
| work_keys_str_mv | AT yufengjia hyaluronicacidbasednanodrugdeliverysystemsforbreastcancertreatmentrecentadvances AT siwenchen hyaluronicacidbasednanodrugdeliverysystemsforbreastcancertreatmentrecentadvances AT siwenchen hyaluronicacidbasednanodrugdeliverysystemsforbreastcancertreatmentrecentadvances AT chenyuwang hyaluronicacidbasednanodrugdeliverysystemsforbreastcancertreatmentrecentadvances AT taosun hyaluronicacidbasednanodrugdeliverysystemsforbreastcancertreatmentrecentadvances AT liqunyang hyaluronicacidbasednanodrugdeliverysystemsforbreastcancertreatmentrecentadvances |