Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
Background: Pruritus is a frequent complaint associated with various inflammatory dermatoses. Sleep is often disturbed because of pruritus but the impact of severity and diurnal pattern of pruritus has not been studied so far. Objectives: To estimate the prevalence of nocturnal itch (NI) and its ass...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-09-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_2425_22 |
| _version_ | 1826982626884321280 |
|---|---|
| author | Prakriti Shukla Parul Verma Srishti Tripathi Alok K. Dwivedi Mukesh Shukla Swastika Suvirya |
| author_facet | Prakriti Shukla Parul Verma Srishti Tripathi Alok K. Dwivedi Mukesh Shukla Swastika Suvirya |
| author_sort | Prakriti Shukla |
| collection | DOAJ |
| description | Background:
Pruritus is a frequent complaint associated with various inflammatory dermatoses. Sleep is often disturbed because of pruritus but the impact of severity and diurnal pattern of pruritus has not been studied so far.
Objectives:
To estimate the prevalence of nocturnal itch (NI) and its association with itch severity, sleep disturbance and quality of life (QoL) compared with non-NI in chronic plaque psoriasis (CPP) and chronic spontaneous urticaria (CSU).
Methods:
We performed a cross-sectional study in patients aged ≥18 years with CPP or CSU for at least 6 weeks. A comprehensive in-house questionnaire designed for study formed the basis for categorizing patients into NI and non-NI. Validated instruments like visual analog scale, pruritus grading system, General Sleep Disturbance Scale, and Dermatology life quality index were used to assess itch severity, sleep, and QoL.
Results:
A total of 255 patients (CPP: 131; CSU: 124) were included in this study. Prevalence of NI was 43.5% (95% confidence interval: 34.9%-52.4%) in CPP and 29% (95% confidence interval: 21.2%-37.9%) in CSU. NI was strongly associated with higher pruritus grading system scores in CSU and CPP (regression coefficient = 1.5, P =0.004 and regression coefficient = 1.3, P =0.004, respectively), with impaired sleep (OR = 2.97, P = 0.025) in CPP and with itch-affected sleep in CSU. Itch severity was associated with impaired sleep; however, the association was modified by the presence of NI in CSU patients.
Conclusion:
Nocturnal itch is prevalent in chronic dermatoses and significant for sleep deficit and impaired QoL. Early screening and management of sleep disturbance among patients presenting with nocturnal itch should be routinely undertaken. |
| first_indexed | 2024-03-11T14:50:34Z |
| format | Article |
| id | doaj.art-2ff0cbb206f44e2a85caf3db4c680aca |
| institution | Directory Open Access Journal |
| issn | 2249-4863 2278-7135 |
| language | English |
| last_indexed | 2025-02-18T06:23:33Z |
| publishDate | 2023-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-2ff0cbb206f44e2a85caf3db4c680aca2024-11-11T11:10:56ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352023-09-011291908191610.4103/jfmpc.jfmpc_2425_22Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional studyPrakriti ShuklaParul VermaSrishti TripathiAlok K. DwivediMukesh ShuklaSwastika SuviryaBackground: Pruritus is a frequent complaint associated with various inflammatory dermatoses. Sleep is often disturbed because of pruritus but the impact of severity and diurnal pattern of pruritus has not been studied so far. Objectives: To estimate the prevalence of nocturnal itch (NI) and its association with itch severity, sleep disturbance and quality of life (QoL) compared with non-NI in chronic plaque psoriasis (CPP) and chronic spontaneous urticaria (CSU). Methods: We performed a cross-sectional study in patients aged ≥18 years with CPP or CSU for at least 6 weeks. A comprehensive in-house questionnaire designed for study formed the basis for categorizing patients into NI and non-NI. Validated instruments like visual analog scale, pruritus grading system, General Sleep Disturbance Scale, and Dermatology life quality index were used to assess itch severity, sleep, and QoL. Results: A total of 255 patients (CPP: 131; CSU: 124) were included in this study. Prevalence of NI was 43.5% (95% confidence interval: 34.9%-52.4%) in CPP and 29% (95% confidence interval: 21.2%-37.9%) in CSU. NI was strongly associated with higher pruritus grading system scores in CSU and CPP (regression coefficient = 1.5, P =0.004 and regression coefficient = 1.3, P =0.004, respectively), with impaired sleep (OR = 2.97, P = 0.025) in CPP and with itch-affected sleep in CSU. Itch severity was associated with impaired sleep; however, the association was modified by the presence of NI in CSU patients. Conclusion: Nocturnal itch is prevalent in chronic dermatoses and significant for sleep deficit and impaired QoL. Early screening and management of sleep disturbance among patients presenting with nocturnal itch should be routinely undertaken.https://journals.lww.com/10.4103/jfmpc.jfmpc_2425_22nocturnal prurituspsoriasisquality of lifesleepurticaria |
| spellingShingle | Prakriti Shukla Parul Verma Srishti Tripathi Alok K. Dwivedi Mukesh Shukla Swastika Suvirya Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study Journal of Family Medicine and Primary Care nocturnal pruritus psoriasis quality of life sleep urticaria |
| title | Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study |
| title_full | Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study |
| title_fullStr | Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study |
| title_full_unstemmed | Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study |
| title_short | Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study |
| title_sort | association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria a cross sectional study |
| topic | nocturnal pruritus psoriasis quality of life sleep urticaria |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_2425_22 |
| work_keys_str_mv | AT prakritishukla associationofprurituswithsleepinpatientswithpsoriasisandchronicspontaneousurticariaacrosssectionalstudy AT parulverma associationofprurituswithsleepinpatientswithpsoriasisandchronicspontaneousurticariaacrosssectionalstudy AT srishtitripathi associationofprurituswithsleepinpatientswithpsoriasisandchronicspontaneousurticariaacrosssectionalstudy AT alokkdwivedi associationofprurituswithsleepinpatientswithpsoriasisandchronicspontaneousurticariaacrosssectionalstudy AT mukeshshukla associationofprurituswithsleepinpatientswithpsoriasisandchronicspontaneousurticariaacrosssectionalstudy AT swastikasuvirya associationofprurituswithsleepinpatientswithpsoriasisandchronicspontaneousurticariaacrosssectionalstudy |