Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

Abstract Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease (AD). The blood-brain barrier (BBB) is essential for keeping toxic...

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Bibliographic Details
Main Authors: Shuang Lei, Jian Li, Jingjun Yu, Fulong Li, Yaping Pan, Xu Chen, Chunliang Ma, Weidong Zhao, Xiaolin Tang
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:International Journal of Oral Science
Online Access:https://doi.org/10.1038/s41368-022-00215-y

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