Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation
We have performed numerical simulations to examine saccular cerebral aneurysm formation at the outer curve of a bent artery. A U-shaped arterial geometry with torsion, which was modeled on part of the human internal carotid artery, has been employed. A new numerical model was proposed to take into a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Mechanical Engineers
2008-09-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/3/3/3_3_431/_pdf/-char/en |
| _version_ | 1818532554639147008 |
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| author | Yuji SHIMOGONYA Takuji ISHIKAWA Yohsuke IMAI Daisuke MORI Noriaki MATSUKI Takami YAMAGUCHI |
| author_facet | Yuji SHIMOGONYA Takuji ISHIKAWA Yohsuke IMAI Daisuke MORI Noriaki MATSUKI Takami YAMAGUCHI |
| author_sort | Yuji SHIMOGONYA |
| collection | DOAJ |
| description | We have performed numerical simulations to examine saccular cerebral aneurysm formation at the outer curve of a bent artery. A U-shaped arterial geometry with torsion, which was modeled on part of the human internal carotid artery, has been employed. A new numerical model was proposed to take into account proliferation as well as degradation of the arterial wall. Proliferation of the arterial wall was modeled by surface area expansion in high wall shear stress region. Based on wall shear stress distribution on the artery, we have investigated aneurysm formation for the following three conditions: (a) strength degradation of the wall, (b) proliferation of the wall, and (c) both strength degradation and proliferation of the wall. A saccular aneurysm shape was not observed when considering only arterial wall degradation up to 90%. However, the saccular shape formed when proliferation of the arterial wall was also taken into consideration. The resultant shape was consistent with clinical observations. Our findings have suggested that a saccular aneurysm may not be formed by degradation of the arterial wall alone, but also require its proliferation. |
| first_indexed | 2024-12-11T17:47:03Z |
| format | Article |
| id | doaj.art-2ff22ad0b05e4344a12c1f894a27fb9b |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-12-11T17:47:03Z |
| publishDate | 2008-09-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-2ff22ad0b05e4344a12c1f894a27fb9b2022-12-22T00:56:20ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632008-09-013343144210.1299/jbse.3.431jbseFormation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational InvestigationYuji SHIMOGONYA0Takuji ISHIKAWA1Yohsuke IMAI2Daisuke MORI3Noriaki MATSUKI4Takami YAMAGUCHI5Department of Bioengineering and Robotics, Graduate Shool of Engineering, Tohoku UniversityDepartment of Bioengineering and Robotics, Graduate Shool of Engineering, Tohoku UniversityDepartment of Bioengineering and Robotics, Graduate Shool of Engineering, Tohoku UniversityDepartment of Mechanical Engineering, Hachinohe National College of TechnologyDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku UniversityDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku UniversityWe have performed numerical simulations to examine saccular cerebral aneurysm formation at the outer curve of a bent artery. A U-shaped arterial geometry with torsion, which was modeled on part of the human internal carotid artery, has been employed. A new numerical model was proposed to take into account proliferation as well as degradation of the arterial wall. Proliferation of the arterial wall was modeled by surface area expansion in high wall shear stress region. Based on wall shear stress distribution on the artery, we have investigated aneurysm formation for the following three conditions: (a) strength degradation of the wall, (b) proliferation of the wall, and (c) both strength degradation and proliferation of the wall. A saccular aneurysm shape was not observed when considering only arterial wall degradation up to 90%. However, the saccular shape formed when proliferation of the arterial wall was also taken into consideration. The resultant shape was consistent with clinical observations. Our findings have suggested that a saccular aneurysm may not be formed by degradation of the arterial wall alone, but also require its proliferation.https://www.jstage.jst.go.jp/article/jbse/3/3/3_3_431/_pdf/-char/encerebral aneurysmgrowthmodelingwall shear stressnumerical analysis |
| spellingShingle | Yuji SHIMOGONYA Takuji ISHIKAWA Yohsuke IMAI Daisuke MORI Noriaki MATSUKI Takami YAMAGUCHI Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation Journal of Biomechanical Science and Engineering cerebral aneurysm growth modeling wall shear stress numerical analysis |
| title | Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation |
| title_full | Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation |
| title_fullStr | Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation |
| title_full_unstemmed | Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation |
| title_short | Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation |
| title_sort | formation of saccular cerebral aneurysms may require proliferation of the arterial wall computational investigation |
| topic | cerebral aneurysm growth modeling wall shear stress numerical analysis |
| url | https://www.jstage.jst.go.jp/article/jbse/3/3/3_3_431/_pdf/-char/en |
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