Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study
Background: Infertility is a global public health issue affecting couples. Trace metals have been implicated in effective reproductive functions in males but less studied in females. Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with u...
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| 格式: | 文件 |
| 语言: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| 丛编: | Nigerian Postgraduate Medical Journal |
| 主题: | |
| 在线阅读: | http://www.npmj.org/article.asp?issn=1117-1936;year=2023;volume=30;issue=4;spage=269;epage=274;aulast=Adeniyi |
| _version_ | 1827295549559144448 |
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| author | Adewale Ayodeji Adeniyi Olayinka Oladunjoye Ogunbode Ayodeji Sylvester Adeyanju Adesina Oladokun |
| author_facet | Adewale Ayodeji Adeniyi Olayinka Oladunjoye Ogunbode Ayodeji Sylvester Adeyanju Adesina Oladokun |
| author_sort | Adewale Ayodeji Adeniyi |
| collection | DOAJ |
| description | Background: Infertility is a global public health issue affecting couples. Trace metals have been implicated in effective reproductive functions in males but less studied in females. Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with unexplained infertility and fertile women. Subjects and Methods: This was a cross-sectional analytical study that compared 75 consenting women who had unexplained infertility with 74 fertile women that were controls. Both groups were seen within 1 year of delivery and were recruited from the family planning unit, at the University College Hospital, Ibadan. Data were obtained through a semi-structured questionnaire, after which 10 mL of venous blood was collected. Analysis of selected trace elements were done by atomic absorption spectrophotometry. IBM SPSS version 23 was utilized for data analysis and the levels of statistical significance was set at <0.05. Results: The mean (± SD) serum concentrations of Cu (93.11 ± 16.55 μg/dL), Zn (72.04 ± 15.03 μg/dL) and Se (28.28 ± 8.33 μg/dL) amongst the women with unexplained infertility were lower when compared to the control group (all with P < 0.001). The serum Cu/Zn ratio was higher among the fertile women, though not statistically significant (P < 0.62). Age of <35 years was associated with normal serum levels of Cu (P < 0.01), while women with normal body mass index had low serum concentrations of Cu (P = 0.04), amongst the fertile group. Conclusion: Serum copper, zinc and selenium concentrations are significantly lower in women with unexplained infertility, therefore diets or supplements containing these trace elements may be helpful in their management. |
| first_indexed | 2024-04-24T14:21:16Z |
| format | Article |
| id | doaj.art-2ff32636c46041b486744913cfd036fc |
| institution | Directory Open Access Journal |
| issn | 1117-1936 2468-6875 |
| language | English |
| last_indexed | 2024-04-24T14:21:16Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Postgraduate Medical Journal |
| spelling | doaj.art-2ff32636c46041b486744913cfd036fc2024-04-03T06:28:15ZengWolters Kluwer Medknow PublicationsNigerian Postgraduate Medical Journal1117-19362468-68752023-01-0130426927410.4103/npmj.npmj_144_23Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical studyAdewale Ayodeji AdeniyiOlayinka Oladunjoye OgunbodeAyodeji Sylvester AdeyanjuAdesina OladokunBackground: Infertility is a global public health issue affecting couples. Trace metals have been implicated in effective reproductive functions in males but less studied in females. Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with unexplained infertility and fertile women. Subjects and Methods: This was a cross-sectional analytical study that compared 75 consenting women who had unexplained infertility with 74 fertile women that were controls. Both groups were seen within 1 year of delivery and were recruited from the family planning unit, at the University College Hospital, Ibadan. Data were obtained through a semi-structured questionnaire, after which 10 mL of venous blood was collected. Analysis of selected trace elements were done by atomic absorption spectrophotometry. IBM SPSS version 23 was utilized for data analysis and the levels of statistical significance was set at <0.05. Results: The mean (± SD) serum concentrations of Cu (93.11 ± 16.55 μg/dL), Zn (72.04 ± 15.03 μg/dL) and Se (28.28 ± 8.33 μg/dL) amongst the women with unexplained infertility were lower when compared to the control group (all with P < 0.001). The serum Cu/Zn ratio was higher among the fertile women, though not statistically significant (P < 0.62). Age of <35 years was associated with normal serum levels of Cu (P < 0.01), while women with normal body mass index had low serum concentrations of Cu (P = 0.04), amongst the fertile group. Conclusion: Serum copper, zinc and selenium concentrations are significantly lower in women with unexplained infertility, therefore diets or supplements containing these trace elements may be helpful in their management.http://www.npmj.org/article.asp?issn=1117-1936;year=2023;volume=30;issue=4;spage=269;epage=274;aulast=Adeniyicopperseleniumtrace elementsunexplained infertilityzinc |
| spellingShingle | Adewale Ayodeji Adeniyi Olayinka Oladunjoye Ogunbode Ayodeji Sylvester Adeyanju Adesina Oladokun Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study Nigerian Postgraduate Medical Journal copper selenium trace elements unexplained infertility zinc |
| title | Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study |
| title_full | Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study |
| title_fullStr | Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study |
| title_full_unstemmed | Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study |
| title_short | Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study |
| title_sort | serum copper zinc and selenium levels in women with unexplained infertility in ibadan nigeria a cross sectional analytical study |
| topic | copper selenium trace elements unexplained infertility zinc |
| url | http://www.npmj.org/article.asp?issn=1117-1936;year=2023;volume=30;issue=4;spage=269;epage=274;aulast=Adeniyi |
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