The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine
Evaluation of how genetic mutations or variability can directly affect phenotypic outcomes, the development of disease, or determination of a tailored treatment protocol is fundamental to advancing personalized medicine. To understand how a genotype affects gene expression and specific phenotypic tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | http://www.mdpi.com/2075-4426/5/1/22 |
| _version_ | 1797710218250944512 |
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| author | Judy C. Keen Helen M. Moore |
| author_facet | Judy C. Keen Helen M. Moore |
| author_sort | Judy C. Keen |
| collection | DOAJ |
| description | Evaluation of how genetic mutations or variability can directly affect phenotypic outcomes, the development of disease, or determination of a tailored treatment protocol is fundamental to advancing personalized medicine. To understand how a genotype affects gene expression and specific phenotypic traits, as well as the correlative and causative associations between such, the Genotype-Tissue Expression (GTEx) Project was initiated The GTEx collection of biospecimens and associated clinical data links extensive clinical data with genotype and gene expression data to provide a wealth of data and resources to study the underlying genetics of normal physiology. These data will help inform personalized medicine through the identification of normal variation that does not contribute to disease. Additionally, these data can lead to insights into how gene variation affects pharmacodynamics and individualized responses to therapy. |
| first_indexed | 2024-03-12T06:49:00Z |
| format | Article |
| id | doaj.art-2ff32a0179ce4ed19c92f3c665a5af75 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-12T06:49:00Z |
| publishDate | 2015-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-2ff32a0179ce4ed19c92f3c665a5af752023-09-03T00:25:26ZengMDPI AGJournal of Personalized Medicine2075-44262015-02-0151222910.3390/jpm5010022jpm5010022The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized MedicineJudy C. Keen0Helen M. Moore1Biorepositories and Biospecimen Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USABiorepositories and Biospecimen Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USAEvaluation of how genetic mutations or variability can directly affect phenotypic outcomes, the development of disease, or determination of a tailored treatment protocol is fundamental to advancing personalized medicine. To understand how a genotype affects gene expression and specific phenotypic traits, as well as the correlative and causative associations between such, the Genotype-Tissue Expression (GTEx) Project was initiated The GTEx collection of biospecimens and associated clinical data links extensive clinical data with genotype and gene expression data to provide a wealth of data and resources to study the underlying genetics of normal physiology. These data will help inform personalized medicine through the identification of normal variation that does not contribute to disease. Additionally, these data can lead to insights into how gene variation affects pharmacodynamics and individualized responses to therapy.http://www.mdpi.com/2075-4426/5/1/22biobankingbiorepositorytissue biospecimengene variationgenotypeGenotype-Tissue Expression |
| spellingShingle | Judy C. Keen Helen M. Moore The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine Journal of Personalized Medicine biobanking biorepository tissue biospecimen gene variation genotype Genotype-Tissue Expression |
| title | The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine |
| title_full | The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine |
| title_fullStr | The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine |
| title_full_unstemmed | The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine |
| title_short | The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine |
| title_sort | genotype tissue expression gtex project linking clinical data with molecular analysis to advance personalized medicine |
| topic | biobanking biorepository tissue biospecimen gene variation genotype Genotype-Tissue Expression |
| url | http://www.mdpi.com/2075-4426/5/1/22 |
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