The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy
Background: Changes in adipokine secretion may be involved in the anti-epileptic effect of a ketogenic diet (KD) in drug-resistant epilepsy (DRE). Objectives: The assessment of the influence of KD on serum adiponectin, omentin-1, and vaspin in children with DRE. Methods: Anthropometric measurements...
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MDPI AG
2022-01-01
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| Online Access: | https://www.mdpi.com/2072-6643/14/3/479 |
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| author | Marcin Chyra Wojciech Roczniak Elżbieta Świętochowska Magdalena Dudzińska Joanna Oświęcimska |
| author_facet | Marcin Chyra Wojciech Roczniak Elżbieta Świętochowska Magdalena Dudzińska Joanna Oświęcimska |
| author_sort | Marcin Chyra |
| collection | DOAJ |
| description | Background: Changes in adipokine secretion may be involved in the anti-epileptic effect of a ketogenic diet (KD) in drug-resistant epilepsy (DRE). Objectives: The assessment of the influence of KD on serum adiponectin, omentin-1, and vaspin in children with DRE. Methods: Anthropometric measurements (weight, height, BMI, and waist-to-hip circumference ratio) were performed in 72 children aged 3–9 years, divided into 3 groups: 24 children with DRE treated with KD, 26—treated with valproic acid (VPA), and a control group of 22 children. Biochemical tests included fasting glucose, insulin, beta-hydroxybutyric acid, lipid profile, aminotransferases activities, and blood gasometry. Serum levels of adiponectin, omentin-1 and vaspin were assayed using commercially available ELISA tests. Results: Serum levels of adiponectin and omentin-1 in the KD group were significantly higher and vaspin—lower in comparison to patients receiving VPA and the control group. In all examined children, serum adiponectin and omentin-1 correlated negatively with WHR and serum triglycerides, insulin, fasting glucose, and HOMA-IR. Vaspin levels correlated negatively with serum triglycerides and positively with body weight, BMI, fasting glucose, insulin, and HOMA-IR. Conclusion: One of the potential mechanisms of KD in children with drug-resistant epilepsy may be a modulation of metabolically beneficial and anti-inflammatory adipokine levels. |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T23:22:13Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-2ff44d6cb04b488a81c306db7b6896c62023-11-23T17:24:25ZengMDPI AGNutrients2072-66432022-01-0114347910.3390/nu14030479The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant EpilepsyMarcin Chyra0Wojciech Roczniak1Elżbieta Świętochowska2Magdalena Dudzińska3Joanna Oświęcimska4Department of Paediatric Neurology, Independent Public Healthcare Centre—Municipal Hospital Complex, ul. Władysława Truchana 7, 41-500 Chorzow, PolandInstitute of Medicine, Jan Grodek State University in Sanok, ul. Mickiewicza 21, 38-500 Sanok, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, PolandDepartment of Paediatric Neurology, Independent Public Healthcare Centre—Municipal Hospital Complex, ul. Władysława Truchana 7, 41-500 Chorzow, PolandInstitute of Medicine, Jan Grodek State University in Sanok, ul. Mickiewicza 21, 38-500 Sanok, PolandBackground: Changes in adipokine secretion may be involved in the anti-epileptic effect of a ketogenic diet (KD) in drug-resistant epilepsy (DRE). Objectives: The assessment of the influence of KD on serum adiponectin, omentin-1, and vaspin in children with DRE. Methods: Anthropometric measurements (weight, height, BMI, and waist-to-hip circumference ratio) were performed in 72 children aged 3–9 years, divided into 3 groups: 24 children with DRE treated with KD, 26—treated with valproic acid (VPA), and a control group of 22 children. Biochemical tests included fasting glucose, insulin, beta-hydroxybutyric acid, lipid profile, aminotransferases activities, and blood gasometry. Serum levels of adiponectin, omentin-1 and vaspin were assayed using commercially available ELISA tests. Results: Serum levels of adiponectin and omentin-1 in the KD group were significantly higher and vaspin—lower in comparison to patients receiving VPA and the control group. In all examined children, serum adiponectin and omentin-1 correlated negatively with WHR and serum triglycerides, insulin, fasting glucose, and HOMA-IR. Vaspin levels correlated negatively with serum triglycerides and positively with body weight, BMI, fasting glucose, insulin, and HOMA-IR. Conclusion: One of the potential mechanisms of KD in children with drug-resistant epilepsy may be a modulation of metabolically beneficial and anti-inflammatory adipokine levels.https://www.mdpi.com/2072-6643/14/3/479adiponectinomentin-1vaspinketogenic dietdrug-resistant epilepsychildren |
| spellingShingle | Marcin Chyra Wojciech Roczniak Elżbieta Świętochowska Magdalena Dudzińska Joanna Oświęcimska The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy Nutrients adiponectin omentin-1 vaspin ketogenic diet drug-resistant epilepsy children |
| title | The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy |
| title_full | The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy |
| title_fullStr | The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy |
| title_full_unstemmed | The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy |
| title_short | The Effect of the Ketogenic Diet on Adiponectin, Omentin and Vaspin in Children with Drug-Resistant Epilepsy |
| title_sort | effect of the ketogenic diet on adiponectin omentin and vaspin in children with drug resistant epilepsy |
| topic | adiponectin omentin-1 vaspin ketogenic diet drug-resistant epilepsy children |
| url | https://www.mdpi.com/2072-6643/14/3/479 |
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