Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs
IntroductionMost T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regul...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1023064/full |
| _version_ | 1797878001107468288 |
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| author | Natalia Bowakim-Anta Valérie Acolty Abdulkader Azouz Hideo Yagita Oberdan Leo Stanislas Goriely Stanislas Goriely Guillaume Oldenhove Muriel Moser |
| author_facet | Natalia Bowakim-Anta Valérie Acolty Abdulkader Azouz Hideo Yagita Oberdan Leo Stanislas Goriely Stanislas Goriely Guillaume Oldenhove Muriel Moser |
| author_sort | Natalia Bowakim-Anta |
| collection | DOAJ |
| description | IntroductionMost T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown.MethodsIn this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4+ T cells in vivo, in the absence of intentional antigenic stimulation.ResultsOur data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion.ConclusionWe conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory. |
| first_indexed | 2024-04-10T02:25:50Z |
| format | Article |
| id | doaj.art-2ff475beb5f84be899b36ae5412f82bd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T02:25:50Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2ff475beb5f84be899b36ae5412f82bd2023-03-13T08:05:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.10230641023064Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector TregsNatalia Bowakim-Anta0Valérie Acolty1Abdulkader Azouz2Hideo Yagita3Oberdan Leo4Stanislas Goriely5Stanislas Goriely6Guillaume Oldenhove7Muriel Moser8Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, BelgiumLaboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, BelgiumInstitute for Medical Immunology, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Gosselies, BelgiumDepartment of Immunology, Juntendo University School of Medicine, Tokyo, JapanLaboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, BelgiumLaboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, BelgiumInstitute for Medical Immunology, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Gosselies, BelgiumLaboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, BelgiumLaboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, BelgiumIntroductionMost T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown.MethodsIn this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4+ T cells in vivo, in the absence of intentional antigenic stimulation.ResultsOur data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion.ConclusionWe conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1023064/fullCD27 costimulationregulatory T cellsdendritic cellseomesCXCR3 |
| spellingShingle | Natalia Bowakim-Anta Valérie Acolty Abdulkader Azouz Hideo Yagita Oberdan Leo Stanislas Goriely Stanislas Goriely Guillaume Oldenhove Muriel Moser Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs Frontiers in Immunology CD27 costimulation regulatory T cells dendritic cells eomes CXCR3 |
| title | Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs |
| title_full | Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs |
| title_fullStr | Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs |
| title_full_unstemmed | Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs |
| title_short | Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs |
| title_sort | chronic cd27 cd70 costimulation promotes type 1 specific polarization of effector tregs |
| topic | CD27 costimulation regulatory T cells dendritic cells eomes CXCR3 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1023064/full |
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