Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs

IntroductionMost T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regul...

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Bibliographic Details
Main Authors: Natalia Bowakim-Anta, Valérie Acolty, Abdulkader Azouz, Hideo Yagita, Oberdan Leo, Stanislas Goriely, Guillaume Oldenhove, Muriel Moser
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
CD27 costimulation
regulatory T cells
dendritic cells
eomes
CXCR3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1023064/full

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