The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development
Summary: The establishment, proliferation, and differentiation of stem cells are coordinated with organ development and regulated by the signals in the microenvironment. Prior to gonad formation, how primordial germ cells (PGC) differentiate spatiotemporally to coordinate with gonadogenesis is uncle...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223027876 |
| _version_ | 1797378585631129600 |
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| author | Xian Liu Xin Li Zhaohui Wang |
| author_facet | Xian Liu Xin Li Zhaohui Wang |
| author_sort | Xian Liu |
| collection | DOAJ |
| description | Summary: The establishment, proliferation, and differentiation of stem cells are coordinated with organ development and regulated by the signals in the microenvironment. Prior to gonad formation, how primordial germ cells (PGC) differentiate spatiotemporally to coordinate with gonadogenesis is unclear. In adult ovary, drosophila extracellular glypican Dally in germline stem cell (GSC) niche promotes BMP signaling to inhibit germline differentiation. Here we investigated the relation between the fate of PGC and the spatiotemporal pattern of glypican during ovary development. We found that Dally in ovarian soma assisted BMP signaling to prevent PGC from precocious differentiation. Dally’s presence raises the “hurdle” for ecdysone peaks to eventually remove the transcription factor Kr and de-repress pro-differentiation factor, temporally postponing PGC differentiation until GSC niche establishment. The spatiotemporal glypican in somatic matrix assists PGC to integrate the ovarian local BMP and organismal steroid signals that coordinate PGC’s program with organ/body development to maximize reproductive potential. |
| first_indexed | 2024-03-08T20:09:53Z |
| format | Article |
| id | doaj.art-2ff4f2f16d2f4bc5a61bc179dce650c7 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T20:09:53Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-2ff4f2f16d2f4bc5a61bc179dce650c72023-12-23T05:22:28ZengElsevieriScience2589-00422024-01-01271108710The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary developmentXian Liu0Xin Li1Zhaohui Wang2State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, P.R. China; The University of Chinese Academy of Sciences, Beijing 100049, P.R. ChinaState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, P.R. ChinaState Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, P.R. China; The University of Chinese Academy of Sciences, Beijing 100049, P.R. China; Corresponding authorSummary: The establishment, proliferation, and differentiation of stem cells are coordinated with organ development and regulated by the signals in the microenvironment. Prior to gonad formation, how primordial germ cells (PGC) differentiate spatiotemporally to coordinate with gonadogenesis is unclear. In adult ovary, drosophila extracellular glypican Dally in germline stem cell (GSC) niche promotes BMP signaling to inhibit germline differentiation. Here we investigated the relation between the fate of PGC and the spatiotemporal pattern of glypican during ovary development. We found that Dally in ovarian soma assisted BMP signaling to prevent PGC from precocious differentiation. Dally’s presence raises the “hurdle” for ecdysone peaks to eventually remove the transcription factor Kr and de-repress pro-differentiation factor, temporally postponing PGC differentiation until GSC niche establishment. The spatiotemporal glypican in somatic matrix assists PGC to integrate the ovarian local BMP and organismal steroid signals that coordinate PGC’s program with organ/body development to maximize reproductive potential.http://www.sciencedirect.com/science/article/pii/S2589004223027876Molecular biologyStem cells researchModel organism |
| spellingShingle | Xian Liu Xin Li Zhaohui Wang The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development iScience Molecular biology Stem cells research Model organism |
| title | The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development |
| title_full | The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development |
| title_fullStr | The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development |
| title_full_unstemmed | The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development |
| title_short | The spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development |
| title_sort | spatiotemporal pattern of glypican coordinates primordial germ cell differentiation with ovary development |
| topic | Molecular biology Stem cells research Model organism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223027876 |
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