Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles
Mutagenous and mitosis modifying impact of silver nanoparticles has been studied on outbred mice. Nanoparticles were of round shape with dimensions of 5-50 nm, size of generated organic shell of 2-5 nm, the quantity in 1 mcm3 makes 120-270. Metaphasic analysis of mice bone marrow cells was used as a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2015-04-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/363 |
| _version_ | 1797703572122501120 |
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| author | B. S. Kirbik S. V. Tikhomirova I. A. Bitkin D. S. Pesnya |
| author_facet | B. S. Kirbik S. V. Tikhomirova I. A. Bitkin D. S. Pesnya |
| author_sort | B. S. Kirbik |
| collection | DOAJ |
| description | Mutagenous and mitosis modifying impact of silver nanoparticles has been studied on outbred mice. Nanoparticles were of round shape with dimensions of 5-50 nm, size of generated organic shell of 2-5 nm, the quantity in 1 mcm3 makes 120-270. Metaphasic analysis of mice bone marrow cells was used as a testing technique. The frequency of chromosome aberrations and mitotic index of preparations were accounted. During single intraperitoneal administration of the agent in the dose of 250 mcg/kg the silver nanoparticles demonstrated mitosis stimulating activity. No mutagenous effect of silver nanoparticles by daily administration for 4 days of 25 mcg/kg and single administration in the dose of 250 mcg/kg has been registered, but there is statistically insignificant tendency of aberrant metaphases increase. Consequently silver nanoparticles in the investigated doses demonstrated no mutagenous activity and can be considered safe for mammalian cells. |
| first_indexed | 2024-03-12T05:06:31Z |
| format | Article |
| id | doaj.art-2ff5fc9fbc06468db4b77ef3858756d9 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T05:06:31Z |
| publishDate | 2015-04-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-2ff5fc9fbc06468db4b77ef3858756d92023-09-03T08:55:18ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062015-04-0104545710.21292/2075-1230-2015-0-4-54-57363Experimental study of mutagenous and mitosis modifying activity of silver nanoparticlesB. S. Kirbik0S. V. Tikhomirova1I. A. Bitkin2D. S. Pesnya3Лаборатория токсикологии НИИ «Ярсинтез»; Ярославская государственная медицинская академияЛаборатория токсикологии НИИ «Ярсинтез»; Ярославская государственная медицинская академия, г. ЯрославльЛаборатория токсикологии НИИ «Ярсинтез»; Ярославская государственная медицинская академия, г. ЯрославльЯрославский Государственный университета им. П. Г. Демидова, г. ЯрославльMutagenous and mitosis modifying impact of silver nanoparticles has been studied on outbred mice. Nanoparticles were of round shape with dimensions of 5-50 nm, size of generated organic shell of 2-5 nm, the quantity in 1 mcm3 makes 120-270. Metaphasic analysis of mice bone marrow cells was used as a testing technique. The frequency of chromosome aberrations and mitotic index of preparations were accounted. During single intraperitoneal administration of the agent in the dose of 250 mcg/kg the silver nanoparticles demonstrated mitosis stimulating activity. No mutagenous effect of silver nanoparticles by daily administration for 4 days of 25 mcg/kg and single administration in the dose of 250 mcg/kg has been registered, but there is statistically insignificant tendency of aberrant metaphases increase. Consequently silver nanoparticles in the investigated doses demonstrated no mutagenous activity and can be considered safe for mammalian cells.https://www.tibl-journal.com/jour/article/view/363наночастицы серебрамитотический индексхромосомные аберрацииметафазный анализметафазамыши |
| spellingShingle | B. S. Kirbik S. V. Tikhomirova I. A. Bitkin D. S. Pesnya Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles Туберкулез и болезни лёгких наночастицы серебра митотический индекс хромосомные аберрации метафазный анализ метафаза мыши |
| title | Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles |
| title_full | Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles |
| title_fullStr | Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles |
| title_full_unstemmed | Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles |
| title_short | Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles |
| title_sort | experimental study of mutagenous and mitosis modifying activity of silver nanoparticles |
| topic | наночастицы серебра митотический индекс хромосомные аберрации метафазный анализ метафаза мыши |
| url | https://www.tibl-journal.com/jour/article/view/363 |
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