Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice
Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazon...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2014-07-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000400517&lng=en&tlng=en |
| _version_ | 1829111566594736128 |
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| author | Ana Angélica Amorim Santarem Gabriel Frizon Greggianin Rafaela Garcia Debastiani Jefferson Bruno Pereira Ribeiro Demerson Andre Polli Raimunda Nonata Ribeiro Sampaio |
| author_facet | Ana Angélica Amorim Santarem Gabriel Frizon Greggianin Rafaela Garcia Debastiani Jefferson Bruno Pereira Ribeiro Demerson Andre Polli Raimunda Nonata Ribeiro Sampaio |
| author_sort | Ana Angélica Amorim Santarem |
| collection | DOAJ |
| description | Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection. |
| first_indexed | 2024-12-12T12:22:32Z |
| format | Article |
| id | doaj.art-2ff6c064d19c4743aed2d7f287edf2ec |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T12:22:32Z |
| publishDate | 2014-07-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-2ff6c064d19c4743aed2d7f287edf2ec2022-12-22T00:24:38ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492014-07-0147451752010.1590/0037-8682-0202-2013S0037-86822014000400517Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 miceAna Angélica Amorim SantaremGabriel Frizon GreggianinRafaela Garcia DebastianiJefferson Bruno Pereira RibeiroDemerson Andre PolliRaimunda Nonata Ribeiro SampaioIntroduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000400517&lng=en&tlng=enCutaneous leishmaniasisPentoxifyllineMiltefosine |
| spellingShingle | Ana Angélica Amorim Santarem Gabriel Frizon Greggianin Rafaela Garcia Debastiani Jefferson Bruno Pereira Ribeiro Demerson Andre Polli Raimunda Nonata Ribeiro Sampaio Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice Revista da Sociedade Brasileira de Medicina Tropical Cutaneous leishmaniasis Pentoxifylline Miltefosine |
| title | Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice |
| title_full | Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice |
| title_fullStr | Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice |
| title_full_unstemmed | Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice |
| title_short | Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice |
| title_sort | effectiveness of miltefosine pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in c57bl 6 mice |
| topic | Cutaneous leishmaniasis Pentoxifylline Miltefosine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000400517&lng=en&tlng=en |
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