Development of a biomimetic peptide-based nanoformulation against the breast cancer
Nanotechnology has enabled preparation of various materials for overcoming the rapid clearance of drugs, non-specific uptake or actions, and poor tumor penetration. Based on the significance of using the biomimetic substances, silk fibroin nanoparticles (SF-NPs) have been increasingly prepared for d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2021-08-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8794 |
| Summary: | Nanotechnology has enabled preparation of various materials for overcoming the rapid clearance of drugs, non-specific uptake or actions, and poor tumor penetration. Based on the significance of using the biomimetic substances, silk fibroin nanoparticles (SF-NPs) have been increasingly prepared for delivery of therapeutics. Meanwhile, aggregation and low stability in the biological medium may negatively affect their efficiency. This prompted us to coat SF-NPs with polydopamine (PDA) and for efficient accumulation and increasing therapeutic efficiency against the breast cancer, paclitaxel (PTX)-loaded PDA-coated SF-NPs were conjugated with targeting peptide, iRGD (iRGD-PDA-PTX-SF-NPs). The peptide impacts on the cellular uptake, cytotoxicity, tumor penetrability of NPs, and their anti-tumor effects were evaluated. iRGD-PDA-PTX-SF-NPs with suitable physicochemical characteristics and drug loading, released PTX in a controlled manner and efficient cellular uptake was observed. Improved pharmacological profile of PTX was revealed by increased anticancer effects in vitro and in tumor-bearing Balb/c mice including the delayed growth of tumor and enhanced rate of survival. The prepared NPs showed no toxic effects against the healthy tissues indicating the histocompatibility and safety of these biomimetic and long-circulating nanoplatforms. The peptide-based SF-NPs could be considered as promising biomimetic nanoformulation against the breast cancer. |
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| ISSN: | 0044-6025 1735-9694 |