Evaluation of Bone Mineral Density in Children with Thalassemia Major
Aim: Fragile bones develop due to various factors in thalassemic patients. Even with optimum management, osteoporosis occurs, contributing to morbidity in majority of patients with thalassemia major (TM). Our aim was to evaluate bone health of thalassemic children using biochemical parameters and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2012-12-01
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| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: | http://www.turkosteoporozdergisi.org/article_4307/Evaluation-Of-Bone-Mineral-Density-In-Children-With-Thalassemia-Major |
| _version_ | 1797909465748471808 |
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| author | Betül Bakan Özlem Gül Eser Fuat Özkan Abdullah Berk Mehmet Alparslan Yılmaz Mesut Garipardıç Vedat Bakan |
| author_facet | Betül Bakan Özlem Gül Eser Fuat Özkan Abdullah Berk Mehmet Alparslan Yılmaz Mesut Garipardıç Vedat Bakan |
| author_sort | Betül Bakan |
| collection | DOAJ |
| description | Aim: Fragile bones develop due to various factors in thalassemic patients. Even with optimum management, osteoporosis occurs, contributing
to morbidity in majority of patients with thalassemia major (TM). Our aim was to evaluate bone health of thalassemic children using biochemical
parameters and bone mineral density (BMD), and to emphasize the precautionary measures and early diagnosis of osteoporosis.
Material and Methods: Thirteen children (5 females, 8 males, age <18 years) with TM were included in the study. Age, duration, weight, height,
transfusion frequency, medication use were recorded. Following laboratory analysis were obtained: Whole blood count, fasting blood glucose, ferritin,
alanine aminotransferase, aspartate aminotransferase, calcium, phosphorus, alkaline phosphatase, thyroid stimulating hormone, free thyroxin, and intact
parathyroid hormone (iPTH). BMD was determined using dual energy X-ray absorptiometry (DXA) from femur and lumbar vertebrae. Patients with DXA
Z-score <-2 was defined as osteoporotic.
Results: The mean age was 7.85±3.17 years and body mass index (BMI) was 14.68±1.93 kg/m2. The rest of the results were as follows: Lumbar
BMD 0.464±0.108 g/cm2; total femur BMD 0.581± 0.114 g/cm2; lumbar DEXA Z-score 2.44±1.60; total femur DEXA -0.93±1.19. Osteoporosis ratio
was determined as 69% in the lumbar vertebrae and 10% in the femur. A significant positive correlation was found between lumbar-femoral BMD
and BMI, and a significant negative correlation was observed between femoral BMD and iPTH.
Conclusion: BMD is low in thalassemic children. Despite regular transfusions and chelation therapy, osteoporosis starts early in life. (Turkish
Journal of Osteoporosis 2012;18: 72-7) |
| first_indexed | 2024-04-10T11:08:41Z |
| format | Article |
| id | doaj.art-2ffdd029a8b04110992661227248d115 |
| institution | Directory Open Access Journal |
| issn | 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T11:08:41Z |
| publishDate | 2012-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-2ffdd029a8b04110992661227248d1152023-02-15T16:19:15ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532012-12-01183727710.4274/tod.70607Evaluation of Bone Mineral Density in Children with Thalassemia MajorBetül Bakan0Özlem Gül Eser1Fuat Özkan2Abdullah Berk3Mehmet Alparslan Yılmaz4Mesut Garipardıç5Vedat Bakan6Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Fizik Tedavi ve Rehabilitasyon Anabilim Dalı, Kahramanmaraş, TürkiyeKahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Çocuk Hematoloji Bilim Dalı, Kahramanmaraş, TürkiyeKahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, Kahramanmaraş, TürkiyeKahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Fizik Tedavi ve Rehabilitasyon Anabilim Dalı, Kahramanmaraş, TürkiyeKahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Fizik Tedavi ve Rehabilitasyon Anabilim Dalı, Kahramanmaraş, TürkiyeKahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Çocuk Hematoloji Bilim Dalı, Kahramanmaraş, TürkiyeKahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Kahramanmaraş, TürkiyeAim: Fragile bones develop due to various factors in thalassemic patients. Even with optimum management, osteoporosis occurs, contributing to morbidity in majority of patients with thalassemia major (TM). Our aim was to evaluate bone health of thalassemic children using biochemical parameters and bone mineral density (BMD), and to emphasize the precautionary measures and early diagnosis of osteoporosis. Material and Methods: Thirteen children (5 females, 8 males, age <18 years) with TM were included in the study. Age, duration, weight, height, transfusion frequency, medication use were recorded. Following laboratory analysis were obtained: Whole blood count, fasting blood glucose, ferritin, alanine aminotransferase, aspartate aminotransferase, calcium, phosphorus, alkaline phosphatase, thyroid stimulating hormone, free thyroxin, and intact parathyroid hormone (iPTH). BMD was determined using dual energy X-ray absorptiometry (DXA) from femur and lumbar vertebrae. Patients with DXA Z-score <-2 was defined as osteoporotic. Results: The mean age was 7.85±3.17 years and body mass index (BMI) was 14.68±1.93 kg/m2. The rest of the results were as follows: Lumbar BMD 0.464±0.108 g/cm2; total femur BMD 0.581± 0.114 g/cm2; lumbar DEXA Z-score 2.44±1.60; total femur DEXA -0.93±1.19. Osteoporosis ratio was determined as 69% in the lumbar vertebrae and 10% in the femur. A significant positive correlation was found between lumbar-femoral BMD and BMI, and a significant negative correlation was observed between femoral BMD and iPTH. Conclusion: BMD is low in thalassemic children. Despite regular transfusions and chelation therapy, osteoporosis starts early in life. (Turkish Journal of Osteoporosis 2012;18: 72-7)http://www.turkosteoporozdergisi.org/article_4307/Evaluation-Of-Bone-Mineral-Density-In-Children-With-Thalassemia-MajorThalassemia majorbone mineral densityosteoporosis |
| spellingShingle | Betül Bakan Özlem Gül Eser Fuat Özkan Abdullah Berk Mehmet Alparslan Yılmaz Mesut Garipardıç Vedat Bakan Evaluation of Bone Mineral Density in Children with Thalassemia Major Türk Osteoporoz Dergisi Thalassemia major bone mineral density osteoporosis |
| title | Evaluation of Bone Mineral Density in Children with Thalassemia Major |
| title_full | Evaluation of Bone Mineral Density in Children with Thalassemia Major |
| title_fullStr | Evaluation of Bone Mineral Density in Children with Thalassemia Major |
| title_full_unstemmed | Evaluation of Bone Mineral Density in Children with Thalassemia Major |
| title_short | Evaluation of Bone Mineral Density in Children with Thalassemia Major |
| title_sort | evaluation of bone mineral density in children with thalassemia major |
| topic | Thalassemia major bone mineral density osteoporosis |
| url | http://www.turkosteoporozdergisi.org/article_4307/Evaluation-Of-Bone-Mineral-Density-In-Children-With-Thalassemia-Major |
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