Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer factors” are an emerging class of TFs that specifically interact with nucleosomal DNA and facilitate accessible genomi...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2021-02-01
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| Series: | Exploration of Targeted Anti-tumor Therapy |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/etat/Article/100231 |
| _version_ | 1818643465802612736 |
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| author | Honey Pavithran Ranjith Kumavath |
| author_facet | Honey Pavithran Ranjith Kumavath |
| author_sort | Honey Pavithran |
| collection | DOAJ |
| description | Transcription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer factors” are an emerging class of TFs that specifically interact with nucleosomal DNA and facilitate accessible genomic binding sites for the additional TFs. There is growing evidence of these specialized modulators in particular malignancies, as highlighted by agents’ clinical efficacy, specifically targeting nuclear hormone receptors. They have been implicated in multiple cancers more recently, with a high proportion inculpating on hormone influential cancers. Moreover, extended crosstalk and cooperation between ERα pioneering factors in estrogen-dependent breast cancer (BC) remain elucidated. This review discusses on the recent advances in our understanding of pioneer TFs in cancer, especially highlighting its potentiality to modulate chromatin condensation to permit ERα recruitment in BC cells. Through the study it was concluded that the highly prospected pioneer TFs in BC, including FOXA1, TLE1, PBX1, and GATA3, possess the potential therapeutic significance and further innovations in the field could yield targeted therapy in cancer treatment. |
| first_indexed | 2024-12-16T23:59:24Z |
| format | Article |
| id | doaj.art-3000b8ad638b413b88c6fefe92468212 |
| institution | Directory Open Access Journal |
| issn | 2692-3114 |
| language | English |
| last_indexed | 2024-12-16T23:59:24Z |
| publishDate | 2021-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Targeted Anti-tumor Therapy |
| spelling | doaj.art-3000b8ad638b413b88c6fefe924682122022-12-21T22:11:06ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142021-02-0121263510.37349/etat.2021.00031Emerging role of pioneer transcription factors in targeted ERα positive breast cancerHoney Pavithran0Ranjith Kumavath1https://orcid.org/0000-0002-0751-5491Department of Genomic Science, School of Biological Sciences, Central University of Kerala, Tejaswini Hills, Periya (PO), Kasaragod, Kerala 671320, IndiaDepartment of Genomic Science, School of Biological Sciences, Central University of Kerala, Tejaswini Hills, Periya (PO), Kasaragod, Kerala 671320, IndiaTranscription factors (TFs) are modular protein groups that preferably bind to DNA sequences and guide genomic expression through transcription. Among these key regulators, “pioneer factors” are an emerging class of TFs that specifically interact with nucleosomal DNA and facilitate accessible genomic binding sites for the additional TFs. There is growing evidence of these specialized modulators in particular malignancies, as highlighted by agents’ clinical efficacy, specifically targeting nuclear hormone receptors. They have been implicated in multiple cancers more recently, with a high proportion inculpating on hormone influential cancers. Moreover, extended crosstalk and cooperation between ERα pioneering factors in estrogen-dependent breast cancer (BC) remain elucidated. This review discusses on the recent advances in our understanding of pioneer TFs in cancer, especially highlighting its potentiality to modulate chromatin condensation to permit ERα recruitment in BC cells. Through the study it was concluded that the highly prospected pioneer TFs in BC, including FOXA1, TLE1, PBX1, and GATA3, possess the potential therapeutic significance and further innovations in the field could yield targeted therapy in cancer treatment.https://www.explorationpub.com/Journals/etat/Article/100231transcription factorpioneer transcription factorserα signalingbreast cancer |
| spellingShingle | Honey Pavithran Ranjith Kumavath Emerging role of pioneer transcription factors in targeted ERα positive breast cancer Exploration of Targeted Anti-tumor Therapy transcription factor pioneer transcription factors erα signaling breast cancer |
| title | Emerging role of pioneer transcription factors in targeted ERα positive breast cancer |
| title_full | Emerging role of pioneer transcription factors in targeted ERα positive breast cancer |
| title_fullStr | Emerging role of pioneer transcription factors in targeted ERα positive breast cancer |
| title_full_unstemmed | Emerging role of pioneer transcription factors in targeted ERα positive breast cancer |
| title_short | Emerging role of pioneer transcription factors in targeted ERα positive breast cancer |
| title_sort | emerging role of pioneer transcription factors in targeted erα positive breast cancer |
| topic | transcription factor pioneer transcription factors erα signaling breast cancer |
| url | https://www.explorationpub.com/Journals/etat/Article/100231 |
| work_keys_str_mv | AT honeypavithran emergingroleofpioneertranscriptionfactorsintargetederapositivebreastcancer AT ranjithkumavath emergingroleofpioneertranscriptionfactorsintargetederapositivebreastcancer |