Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs
Abstract Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Communications Engineering |
| Online Access: | https://doi.org/10.1038/s44172-024-00185-5 |
| _version_ | 1797274429722460160 |
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| author | Ran Xiao Jiaheng Li Yue Fung Wong Lok Ting Chu Yingxin Zhu Liqiang Wang Minghui Wu Dingkun Zhang Meng Gong Joseph Lai Kannie W. Y. Chan Rong Fan Ting-Hsuan Chen Yang Lu |
| author_facet | Ran Xiao Jiaheng Li Yue Fung Wong Lok Ting Chu Yingxin Zhu Liqiang Wang Minghui Wu Dingkun Zhang Meng Gong Joseph Lai Kannie W. Y. Chan Rong Fan Ting-Hsuan Chen Yang Lu |
| author_sort | Ran Xiao |
| collection | DOAJ |
| description | Abstract Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs with user-friendly high-efficiency controlled sample release (CR) mode. Compared with traditional NP swabs, our microlattice NP swabs show higher (~7–11 times) flexibility, larger (~2.3 times) and customizable release volume, higher (dozens to thousands of times) release concentration, high recovery efficiency (~100%), and the ability to quantify analyte levels. Our microlattice NP swabs have been thus demonstrated to improve the sensitivity and accuracy of antibody detection experiments using rapid detection kits. This study offers a promising approach to enhance sensitivity and accuracy in clinical specimen detections, and is beneficial to inspire the design of a wider range of biomedical devices based on 3D-printed microlattice metamaterials. |
| first_indexed | 2024-03-07T14:58:12Z |
| format | Article |
| id | doaj.art-30011527fae14e73a4504bd98d2de0fa |
| institution | Directory Open Access Journal |
| issn | 2731-3395 |
| language | English |
| last_indexed | 2024-03-07T14:58:12Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Engineering |
| spelling | doaj.art-30011527fae14e73a4504bd98d2de0fa2024-03-05T19:17:00ZengNature PortfolioCommunications Engineering2731-33952024-03-013111010.1038/s44172-024-00185-5Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabsRan Xiao0Jiaheng Li1Yue Fung Wong2Lok Ting Chu3Yingxin Zhu4Liqiang Wang5Minghui Wu6Dingkun Zhang7Meng Gong8Joseph Lai9Kannie W. Y. Chan10Rong Fan11Ting-Hsuan Chen12Yang Lu13Department of Mechanical Engineering, City University of Hong KongDepartment of Biomedical Engineering, City University of Hong KongDepartment of Mechanical Engineering, City University of Hong KongDepartment of Biomedical Engineering, City University of Hong KongDepartment of Mechanical Engineering, City University of Hong KongDepartment of Mechanical Engineering, City University of Hong KongDepartment of Biomedical Engineering, City University of Hong KongLaboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityLaboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Biomedical Engineering, City University of Hong KongDepartment of Biomedical Engineering, City University of Hong KongDepartment of Mechanical Engineering, City University of Hong KongDepartment of Biomedical Engineering, City University of Hong KongDepartment of Mechanical Engineering, The University of Hong KongAbstract Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs with user-friendly high-efficiency controlled sample release (CR) mode. Compared with traditional NP swabs, our microlattice NP swabs show higher (~7–11 times) flexibility, larger (~2.3 times) and customizable release volume, higher (dozens to thousands of times) release concentration, high recovery efficiency (~100%), and the ability to quantify analyte levels. Our microlattice NP swabs have been thus demonstrated to improve the sensitivity and accuracy of antibody detection experiments using rapid detection kits. This study offers a promising approach to enhance sensitivity and accuracy in clinical specimen detections, and is beneficial to inspire the design of a wider range of biomedical devices based on 3D-printed microlattice metamaterials.https://doi.org/10.1038/s44172-024-00185-5 |
| spellingShingle | Ran Xiao Jiaheng Li Yue Fung Wong Lok Ting Chu Yingxin Zhu Liqiang Wang Minghui Wu Dingkun Zhang Meng Gong Joseph Lai Kannie W. Y. Chan Rong Fan Ting-Hsuan Chen Yang Lu Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs Communications Engineering |
| title | Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs |
| title_full | Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs |
| title_fullStr | Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs |
| title_full_unstemmed | Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs |
| title_short | Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs |
| title_sort | enhancing detection accuracy via controlled release of 3d printed microlattice nasopharyngeal swabs |
| url | https://doi.org/10.1038/s44172-024-00185-5 |
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