The Healthy Brain Initiative (HBI): A prospective cohort study protocol.
<h4>Background</h4>The Health Brain Initiative (HBI), established by University of Miami's Comprehensive Center for Brain Health (CCBH), follows racially/ethnically diverse older adults without dementia living in South Florida. With dementia prevention and brain health promotion as...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293634&type=printable |
| _version_ | 1827206752501760000 |
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| author | Lilah M Besser Stephanie Chrisphonte Michael J Kleiman Deirdre O'Shea Amie Rosenfeld Magdalena Tolea James E Galvin |
| author_facet | Lilah M Besser Stephanie Chrisphonte Michael J Kleiman Deirdre O'Shea Amie Rosenfeld Magdalena Tolea James E Galvin |
| author_sort | Lilah M Besser |
| collection | DOAJ |
| description | <h4>Background</h4>The Health Brain Initiative (HBI), established by University of Miami's Comprehensive Center for Brain Health (CCBH), follows racially/ethnically diverse older adults without dementia living in South Florida. With dementia prevention and brain health promotion as an overarching goal, HBI will advance scientific knowledge by developing novel assessments and non-invasive biomarkers of Alzheimer's disease and related dementias (ADRD), examining additive effects of sociodemographic, lifestyle, neurological and biobehavioral measures, and employing innovative, methodologically advanced modeling methods to characterize ADRD risk and resilience factors and transition of brain aging.<h4>Methods</h4>HBI is a longitudinal, observational cohort study that will follow 500 deeply-phenotyped participants annually to collect, analyze, and store clinical, cognitive, behavioral, functional, genetic, and neuroimaging data and biospecimens. Participants are ≥50 years old; have no, subjective, or mild cognitive impairment; have a study partner; and are eligible to undergo magnetic resonance imaging (MRI). Recruitment is community-based including advertisements, word-of-mouth, community events, and physician referrals. At baseline, following informed consent, participants complete detailed web-based surveys (e.g., demographics, health history, risk and resilience factors), followed by two half-day visits which include neurological exams, cognitive and functional assessments, an overnight sleep study, and biospecimen collection. Structural and functional MRI is completed by all participants and a subset also consent to amyloid PET imaging. Annual follow-up visits repeat the same data and biospecimen collection as baseline, except that MRIs are conducted every other year after baseline.<h4>Ethics and expected impact</h4>HBI has been approved by the University of Miami Miller School of Medicine Institutional Review Board. Participants provide informed consent at baseline and are re-consented as needed with protocol changes. Data collected by HBI will lead to breakthroughs in developing new diagnostics and therapeutics, creating comprehensive diagnostic evaluations, and providing the evidence base for precision medicine approaches to dementia prevention with individualized treatment plans. |
| first_indexed | 2024-03-08T03:09:36Z |
| format | Article |
| id | doaj.art-30029b7d377e49c396787abcc266acf3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-21T12:29:10Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-30029b7d377e49c396787abcc266acf32024-06-28T05:30:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029363410.1371/journal.pone.0293634The Healthy Brain Initiative (HBI): A prospective cohort study protocol.Lilah M BesserStephanie ChrisphonteMichael J KleimanDeirdre O'SheaAmie RosenfeldMagdalena ToleaJames E Galvin<h4>Background</h4>The Health Brain Initiative (HBI), established by University of Miami's Comprehensive Center for Brain Health (CCBH), follows racially/ethnically diverse older adults without dementia living in South Florida. With dementia prevention and brain health promotion as an overarching goal, HBI will advance scientific knowledge by developing novel assessments and non-invasive biomarkers of Alzheimer's disease and related dementias (ADRD), examining additive effects of sociodemographic, lifestyle, neurological and biobehavioral measures, and employing innovative, methodologically advanced modeling methods to characterize ADRD risk and resilience factors and transition of brain aging.<h4>Methods</h4>HBI is a longitudinal, observational cohort study that will follow 500 deeply-phenotyped participants annually to collect, analyze, and store clinical, cognitive, behavioral, functional, genetic, and neuroimaging data and biospecimens. Participants are ≥50 years old; have no, subjective, or mild cognitive impairment; have a study partner; and are eligible to undergo magnetic resonance imaging (MRI). Recruitment is community-based including advertisements, word-of-mouth, community events, and physician referrals. At baseline, following informed consent, participants complete detailed web-based surveys (e.g., demographics, health history, risk and resilience factors), followed by two half-day visits which include neurological exams, cognitive and functional assessments, an overnight sleep study, and biospecimen collection. Structural and functional MRI is completed by all participants and a subset also consent to amyloid PET imaging. Annual follow-up visits repeat the same data and biospecimen collection as baseline, except that MRIs are conducted every other year after baseline.<h4>Ethics and expected impact</h4>HBI has been approved by the University of Miami Miller School of Medicine Institutional Review Board. Participants provide informed consent at baseline and are re-consented as needed with protocol changes. Data collected by HBI will lead to breakthroughs in developing new diagnostics and therapeutics, creating comprehensive diagnostic evaluations, and providing the evidence base for precision medicine approaches to dementia prevention with individualized treatment plans.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293634&type=printable |
| spellingShingle | Lilah M Besser Stephanie Chrisphonte Michael J Kleiman Deirdre O'Shea Amie Rosenfeld Magdalena Tolea James E Galvin The Healthy Brain Initiative (HBI): A prospective cohort study protocol. PLoS ONE |
| title | The Healthy Brain Initiative (HBI): A prospective cohort study protocol. |
| title_full | The Healthy Brain Initiative (HBI): A prospective cohort study protocol. |
| title_fullStr | The Healthy Brain Initiative (HBI): A prospective cohort study protocol. |
| title_full_unstemmed | The Healthy Brain Initiative (HBI): A prospective cohort study protocol. |
| title_short | The Healthy Brain Initiative (HBI): A prospective cohort study protocol. |
| title_sort | healthy brain initiative hbi a prospective cohort study protocol |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293634&type=printable |
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