Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology
Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023000740 |
| _version_ | 1797384121912131584 |
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| author | Xiusheng Zhu Qitong Huang Jing Luo Dashuai Kong Yubo Zhang |
| author_facet | Xiusheng Zhu Qitong Huang Jing Luo Dashuai Kong Yubo Zhang |
| author_sort | Xiusheng Zhu |
| collection | DOAJ |
| description | Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes and regulatory elements involve different promoters, enhancers, transcription factors, silencers, insulators, and long-range regulatory elements, which occur at a ∼10 µm nucleus in a spatiotemporal manner. In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. In the review, we have briefly summarized the latest processes in three-dimensional chromatin conformation, microscopic imaging, and bioinformatics, and we have presented the outlook and future directions for these three aspects. |
| first_indexed | 2024-03-08T21:30:55Z |
| format | Article |
| id | doaj.art-3003f8564ac6466381350960da82dea5 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:30:55Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-3003f8564ac6466381350960da82dea52023-12-21T07:31:04ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012117281737Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biologyXiusheng Zhu0Qitong Huang1Jing Luo2Dashuai Kong3Yubo Zhang4Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China; Animal Breeding and Genomics, Wageningen University & Research, Wageningen 6708PB, the NetherlandsShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China; School of Life Sciences, Henan University, Kaifeng 475004, ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China; College of Life Science and Engineering, Foshan University, Foshan, China; Corresponding author at: Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes and regulatory elements involve different promoters, enhancers, transcription factors, silencers, insulators, and long-range regulatory elements, which occur at a ∼10 µm nucleus in a spatiotemporal manner. In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. In the review, we have briefly summarized the latest processes in three-dimensional chromatin conformation, microscopic imaging, and bioinformatics, and we have presented the outlook and future directions for these three aspects.http://www.sciencedirect.com/science/article/pii/S2001037023000740Gene regulatory network (GRN)Chromatin conformationMicroscope imagingRegulatory elements |
| spellingShingle | Xiusheng Zhu Qitong Huang Jing Luo Dashuai Kong Yubo Zhang Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology Computational and Structural Biotechnology Journal Gene regulatory network (GRN) Chromatin conformation Microscope imaging Regulatory elements |
| title | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
| title_full | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
| title_fullStr | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
| title_full_unstemmed | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
| title_short | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
| title_sort | mini review gene regulatory network benefits from three dimensional chromatin conformation and structural biology |
| topic | Gene regulatory network (GRN) Chromatin conformation Microscope imaging Regulatory elements |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023000740 |
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