The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats
ABSTRACT PURPOSE: To analysis the effects of passive smoking on the microstructure of tissues of the abdominal wall regarding microcirculation, using histopathological study of the tobacco exposed rats. METHODS: Twenty four male Wistar rats were divided in Control Group (CG = 8 animals) and Expos...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2016-11-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/acb/v31n11/1678-2674-acb-31-11-00714.pdf |
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| author | Paulo Sandler Bernardo Mastella Diego Uchôa Geraldo Pereira Jotz Henrique Záchia Leão Leandro Totti Cavazzola |
| author_facet | Paulo Sandler Bernardo Mastella Diego Uchôa Geraldo Pereira Jotz Henrique Záchia Leão Leandro Totti Cavazzola |
| author_sort | Paulo Sandler |
| collection | DOAJ |
| description | ABSTRACT PURPOSE: To analysis the effects of passive smoking on the microstructure of tissues of the abdominal wall regarding microcirculation, using histopathological study of the tobacco exposed rats. METHODS: Twenty four male Wistar rats were divided in Control Group (CG = 8 animals) and Exposition Groups (EG = 16 animals). EG was exposed to cigarette smoke 4x/day for 120 days, while CG was preserved from exposure. Food, water and housing were similar for both groups. After 120 days, urine samples were collected before necropsy to analyze cotinine levels (ng/mL) in urine and blinded histopathological analysis of the abdominal wall performed to count arteries and veins in dermal and muscular fascia layer. RESULTS: No difference in weight was observed between both groups (P>0.05). Cotinine concentration was significantly higher in EG (P<0.05). In dermal layer, the average of vessels per animal was 8.72 (IC95%: 8.31-9.13) for CG and 11,23 (IC95%: 10.09-12.38) for EG. In muscular fascia layer the average of vessels per animal was 17.97 (IC95%: 15.79-20.15) for CG, whereas the average for EG was of 14,85 (IC95%: 12.71-17.01) (P<0.05). CONCLUSION: Exposition to passive smoking may cause increase in the number of vessels in dermal layer, with the opposite effects at the muscular fascia layer. |
| first_indexed | 2024-12-10T17:24:14Z |
| format | Article |
| id | doaj.art-30043539a9d64753a18afdf6e64048f5 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-10T17:24:14Z |
| publishDate | 2016-11-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-30043539a9d64753a18afdf6e64048f52022-12-22T01:39:53ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502016-11-01311171471910.1590/s0102-865020160110000002The effects of passive tobacco smoking on the microcirculation of the abdominal wall in ratsPaulo SandlerBernardo MastellaDiego UchôaGeraldo Pereira JotzHenrique Záchia LeãoLeandro Totti CavazzolaABSTRACT PURPOSE: To analysis the effects of passive smoking on the microstructure of tissues of the abdominal wall regarding microcirculation, using histopathological study of the tobacco exposed rats. METHODS: Twenty four male Wistar rats were divided in Control Group (CG = 8 animals) and Exposition Groups (EG = 16 animals). EG was exposed to cigarette smoke 4x/day for 120 days, while CG was preserved from exposure. Food, water and housing were similar for both groups. After 120 days, urine samples were collected before necropsy to analyze cotinine levels (ng/mL) in urine and blinded histopathological analysis of the abdominal wall performed to count arteries and veins in dermal and muscular fascia layer. RESULTS: No difference in weight was observed between both groups (P>0.05). Cotinine concentration was significantly higher in EG (P<0.05). In dermal layer, the average of vessels per animal was 8.72 (IC95%: 8.31-9.13) for CG and 11,23 (IC95%: 10.09-12.38) for EG. In muscular fascia layer the average of vessels per animal was 17.97 (IC95%: 15.79-20.15) for CG, whereas the average for EG was of 14,85 (IC95%: 12.71-17.01) (P<0.05). CONCLUSION: Exposition to passive smoking may cause increase in the number of vessels in dermal layer, with the opposite effects at the muscular fascia layer.http://www.scielo.br/pdf/acb/v31n11/1678-2674-acb-31-11-00714.pdfTobacco ProductsAbdominal WallSmoke Inhalation InjuryPhysiopathologyRats |
| spellingShingle | Paulo Sandler Bernardo Mastella Diego Uchôa Geraldo Pereira Jotz Henrique Záchia Leão Leandro Totti Cavazzola The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats Acta Cirúrgica Brasileira Tobacco Products Abdominal Wall Smoke Inhalation Injury Physiopathology Rats |
| title | The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats |
| title_full | The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats |
| title_fullStr | The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats |
| title_full_unstemmed | The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats |
| title_short | The effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats |
| title_sort | effects of passive tobacco smoking on the microcirculation of the abdominal wall in rats |
| topic | Tobacco Products Abdominal Wall Smoke Inhalation Injury Physiopathology Rats |
| url | http://www.scielo.br/pdf/acb/v31n11/1678-2674-acb-31-11-00714.pdf |
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