Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis
Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases. Its treatment with statin is limited by costs, side effects, and drugs interactions. Nutraceuticals appear to have an important metabolic effect on cholestero...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/4/223 |
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| author | Roberta D’Assante Mariarosaria De Luca Sergio Ferraro Andrea Ferraro Antonio Ruvolo Francesco Natale Pietro Sotgiu Maurizio Petitto Romolo Rizzo Umberto De Maria Luigi Liguori Gianluigi Gentile Paola Ragucci Vittorio Donadio Valeria Valente Antonio Cittadini |
| author_facet | Roberta D’Assante Mariarosaria De Luca Sergio Ferraro Andrea Ferraro Antonio Ruvolo Francesco Natale Pietro Sotgiu Maurizio Petitto Romolo Rizzo Umberto De Maria Luigi Liguori Gianluigi Gentile Paola Ragucci Vittorio Donadio Valeria Valente Antonio Cittadini |
| author_sort | Roberta D’Assante |
| collection | DOAJ |
| description | Hypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases. Its treatment with statin is limited by costs, side effects, and drugs interactions. Nutraceuticals appear to have an important metabolic effect on cholesterol reduction as well as on body weight and glycemia. The aim of this study was to evaluate the effect of a nutraceutical combination (Melasterol) in eighty-seven patients with acquired hypercholesterolemia. Clinically relevant parameters were collected at baseline and after three and six months of Melasterol treatment, one tablet per day. The primary endpoint was the change in cholesterol and triglyceride levels. Six months of treatment resulted in a 19.2% decrease in total cholesterol, accompanied by a 19.8% decrease in low-density lipoprotein (LDL) and a 23% reduction in triglycerides (<i>p</i> < 0.001) but not in high-density lipoprotein (HDL) levels (<i>p</i> > 0.05). These results were paralleled by a significative blood glucose (108.3 ± 21.3 vs. 98.4 ± 18.6 mg/dL <i>p</i> < 0.001) and body mass index (BMI) reduction (27.8 ± 4.4 vs. 27.0 ± 4.2 mg/dL, <i>p</i> < 0.001). A subgroup of 12 patients performed flow-mediated dilation, with values increasing by 1.8% (<i>p</i> < 0.05). No significant side effects were reported. Besides its cholesterol-lowering effect, Melasterol was associated with a significant improvement in other relevant metabolic parameters such as BMI and glycemia. |
| first_indexed | 2024-03-10T12:33:39Z |
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| id | doaj.art-300470158bb14cecacefd50a764ac03c |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T12:33:39Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-300470158bb14cecacefd50a764ac03c2023-11-21T14:26:26ZengMDPI AGMetabolites2218-19892021-04-0111422310.3390/metabo11040223Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective AnalysisRoberta D’Assante0Mariarosaria De Luca1Sergio Ferraro2Andrea Ferraro3Antonio Ruvolo4Francesco Natale5Pietro Sotgiu6Maurizio Petitto7Romolo Rizzo8Umberto De Maria9Luigi Liguori10Gianluigi Gentile11Paola Ragucci12Vittorio Donadio13Valeria Valente14Antonio Cittadini15Department of Translational Medical Sciences, Federico II University of Naples, 80100 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University of Naples, 80100 Naples, ItalyA.O.R.N. Ospedali dei Colli–CTO, 80100 Naples, ItalyA.O.R.N. Ospedali dei Colli–CTO, 80100 Naples, ItalyA.O.R.N. Ospedali dei Colli–CTO, 80100 Naples, ItalyA.O.R.N. Ospedali dei Colli–Monaldi, 80100 Naples, ItalyCasa di Cura Maria Rosaria di Pompei, 80100 Naples, ItalySanta Maria della Pietà Camilliani Hospital, 80100 Naples, ItalyA.O.R.N. Ospedali dei Colli–CTO, 80100 Naples, ItalyCentro Gal.Ma.Ca, 80100 Naples, ItalyGeneral Practitioner, Via A. Rocco 13, 80100 Naples, ItalyDistretto 33, ASL Napoli 1, 80100 Naples, ItalyDistretto 33, ASL Napoli 1, 80100 Naples, ItalySander Laboratories, 80100 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University of Naples, 80100 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University of Naples, 80100 Naples, ItalyHypercholesterolemia represents a serious public health problem as it significantly increases the risk of developing cardiovascular diseases. Its treatment with statin is limited by costs, side effects, and drugs interactions. Nutraceuticals appear to have an important metabolic effect on cholesterol reduction as well as on body weight and glycemia. The aim of this study was to evaluate the effect of a nutraceutical combination (Melasterol) in eighty-seven patients with acquired hypercholesterolemia. Clinically relevant parameters were collected at baseline and after three and six months of Melasterol treatment, one tablet per day. The primary endpoint was the change in cholesterol and triglyceride levels. Six months of treatment resulted in a 19.2% decrease in total cholesterol, accompanied by a 19.8% decrease in low-density lipoprotein (LDL) and a 23% reduction in triglycerides (<i>p</i> < 0.001) but not in high-density lipoprotein (HDL) levels (<i>p</i> > 0.05). These results were paralleled by a significative blood glucose (108.3 ± 21.3 vs. 98.4 ± 18.6 mg/dL <i>p</i> < 0.001) and body mass index (BMI) reduction (27.8 ± 4.4 vs. 27.0 ± 4.2 mg/dL, <i>p</i> < 0.001). A subgroup of 12 patients performed flow-mediated dilation, with values increasing by 1.8% (<i>p</i> < 0.05). No significant side effects were reported. Besides its cholesterol-lowering effect, Melasterol was associated with a significant improvement in other relevant metabolic parameters such as BMI and glycemia.https://www.mdpi.com/2218-1989/11/4/223hypercholesterolemiatriglyceridenutraceuticalMelasterolannurca applered yest rice |
| spellingShingle | Roberta D’Assante Mariarosaria De Luca Sergio Ferraro Andrea Ferraro Antonio Ruvolo Francesco Natale Pietro Sotgiu Maurizio Petitto Romolo Rizzo Umberto De Maria Luigi Liguori Gianluigi Gentile Paola Ragucci Vittorio Donadio Valeria Valente Antonio Cittadini Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis Metabolites hypercholesterolemia triglyceride nutraceutical Melasterol annurca apple red yest rice |
| title | Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis |
| title_full | Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis |
| title_fullStr | Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis |
| title_full_unstemmed | Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis |
| title_short | Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis |
| title_sort | beneficial metabolic effect of a nutraceuticals combination monacolin k yeasted red rice polyphenolic extract of annurca apple and berberine on acquired hypercholesterolemia a prospective analysis |
| topic | hypercholesterolemia triglyceride nutraceutical Melasterol annurca apple red yest rice |
| url | https://www.mdpi.com/2218-1989/11/4/223 |
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