Pharmaceutical Biochemistry at the ETH Zürich
Pharmaceutical biochemistry at the ETH Zürich is devoted to research on ligand–macromolecule interactions, combining experiments with computational data as closely as possible because we believe that there is no rational disease treatment without molecular understanding of events. For this...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2004-10-01
|
| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/3896 |
| _version_ | 1798014332925116416 |
|---|---|
| author | Leonardo Scapozza |
| author_facet | Leonardo Scapozza |
| author_sort | Leonardo Scapozza |
| collection | DOAJ |
| description |
Pharmaceutical biochemistry at the ETH Zürich is devoted to research on ligand–macromolecule interactions, combining experiments with computational data as closely as possible because we believe that there is no rational disease treatment without molecular understanding of
events. For this purpose biochemical/biophysical studies of target proteins in complex with their ligands are an essential part of the research. Complementary and integrated to it, a second field of research is dedicated to computational methods that play an important role in drug discovery
and development. These methods are strongly interconnected with the experiments and are used to generate new hypotheses to be tested experimentally. This approach has been made feasible by the progress of molecular biology and computer technology and is now extensively used in all major pharmaceutical
industries and thus has to be taught to students. Because of the interdisciplinarity of the research a multidisciplinary environment has been established. The scientific effort of the group is focused on cancer and antiviral research. Key targets of the research are kinases, namely thymidine
kinases and tyrosine kinases of oncogenic fusion proteins. In parallel and in view of the increasing amount of experimental data generated by the different -omics initiatives the group has started the development of appropriate software tools for data mining.
|
| first_indexed | 2024-04-11T15:16:47Z |
| format | Article |
| id | doaj.art-3004feb6eef840b59f2a7be9dc329c75 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-11T15:16:47Z |
| publishDate | 2004-10-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-3004feb6eef840b59f2a7be9dc329c752022-12-22T04:16:28ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242004-10-01581010.2533/000942904777677399Pharmaceutical Biochemistry at the ETH ZürichLeonardo Scapozza Pharmaceutical biochemistry at the ETH Zürich is devoted to research on ligand–macromolecule interactions, combining experiments with computational data as closely as possible because we believe that there is no rational disease treatment without molecular understanding of events. For this purpose biochemical/biophysical studies of target proteins in complex with their ligands are an essential part of the research. Complementary and integrated to it, a second field of research is dedicated to computational methods that play an important role in drug discovery and development. These methods are strongly interconnected with the experiments and are used to generate new hypotheses to be tested experimentally. This approach has been made feasible by the progress of molecular biology and computer technology and is now extensively used in all major pharmaceutical industries and thus has to be taught to students. Because of the interdisciplinarity of the research a multidisciplinary environment has been established. The scientific effort of the group is focused on cancer and antiviral research. Key targets of the research are kinases, namely thymidine kinases and tyrosine kinases of oncogenic fusion proteins. In parallel and in view of the increasing amount of experimental data generated by the different -omics initiatives the group has started the development of appropriate software tools for data mining. https://chimia.ch/chimia/article/view/3896Drug designKinasesLigand macromolecule interactionProtein engineeringStem cells |
| spellingShingle | Leonardo Scapozza Pharmaceutical Biochemistry at the ETH Zürich CHIMIA Drug design Kinases Ligand macromolecule interaction Protein engineering Stem cells |
| title | Pharmaceutical Biochemistry at the ETH Zürich |
| title_full | Pharmaceutical Biochemistry at the ETH Zürich |
| title_fullStr | Pharmaceutical Biochemistry at the ETH Zürich |
| title_full_unstemmed | Pharmaceutical Biochemistry at the ETH Zürich |
| title_short | Pharmaceutical Biochemistry at the ETH Zürich |
| title_sort | pharmaceutical biochemistry at the eth zurich |
| topic | Drug design Kinases Ligand macromolecule interaction Protein engineering Stem cells |
| url | https://chimia.ch/chimia/article/view/3896 |
| work_keys_str_mv | AT leonardoscapozza pharmaceuticalbiochemistryattheethzurich |