Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study
Objectives: The main purpose of this retrospective cohort study was to provide an evaluation of Ankylosing spondylitis (AS) patients' fibromyalgia risk in different age and sex subgroups by analyzing large study samples.Methods: Datasets from the National Taiwan Insurance Research Database (NHI...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-03-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.618594/full |
| _version_ | 1818622140374581248 |
|---|---|
| author | Shuo-Yan Gau Yung-Heng Lee Yung-Heng Lee Yung-Heng Lee Hsi-Kai Tsou Hsi-Kai Tsou Jing-Yang Huang Jing-Yang Huang Xinpeng Chen Zhizhong Ye James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
| author_facet | Shuo-Yan Gau Yung-Heng Lee Yung-Heng Lee Yung-Heng Lee Hsi-Kai Tsou Hsi-Kai Tsou Jing-Yang Huang Jing-Yang Huang Xinpeng Chen Zhizhong Ye James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
| author_sort | Shuo-Yan Gau |
| collection | DOAJ |
| description | Objectives: The main purpose of this retrospective cohort study was to provide an evaluation of Ankylosing spondylitis (AS) patients' fibromyalgia risk in different age and sex subgroups by analyzing large study samples.Methods: Datasets from the National Taiwan Insurance Research Database (NHIRD) were retrieved in this retrospective cohort study. This study was approved by the Institutional Review Board of Chung Shan Medical University (IRB permit number CS15134). Within the Longitudinal Health Insurance Database (LHID), and the subset of NHIRD, we identified AS patients to explore the risk of further fibromyalgia. The exposure cohort included patients with newly-diagnosed AS (ICD-9-CM:720.0) during 2000–2013. After 1:4 age-sex matching and 1:2 propensity score matching, and adjusting potential confounders, individuals without AS were identified as a comparison cohort. The adjusted hazard ratio of subsequent development of fibromyalgia in people with AS was evaluated. Further stratification analyses of different ages and genders were then undertaken to validate the results.Results: In total, 17 088 individuals were included in the present study, including 5,696 patients with AS and 11,392 individuals without AS. Respective incidence rates (per 1,000 person-months) of fibromyalgia was 0.52 (95% CI, 0.46–0.59) in the AS cohort and 0.39 (95% CI, 0.35–0.44) in the non-AS cohort. Compared with the non-AS cohort, aHR of developing fibromyalgia was 1.32 (95% CI, 1.12–1.55) in people with AS. This association was consistent in both statistical models of 1:4 age–sex matching and 1:2 propensity score matching.Conclusion: Patients with AS were associated with a higher risk of fibromyalgia, especially those over 65 years old. In managing patients with AS, clinicians should be aware of this association, which could impact diagnosis, disease activity evaluation, and treatment. |
| first_indexed | 2024-12-16T18:20:26Z |
| format | Article |
| id | doaj.art-3005d1d376a944068f7407ffd576d980 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-16T18:20:26Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3005d1d376a944068f7407ffd576d9802022-12-21T22:21:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-03-01810.3389/fmed.2021.618594618594Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort StudyShuo-Yan Gau0Yung-Heng Lee1Yung-Heng Lee2Yung-Heng Lee3Hsi-Kai Tsou4Hsi-Kai Tsou5Jing-Yang Huang6Jing-Yang Huang7Xinpeng Chen8Zhizhong Ye9James Cheng-Chung Wei10James Cheng-Chung Wei11James Cheng-Chung Wei12School of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Senior Services Industry Management, Minghsin University of Science and Technology, Hsinchu, TaiwanDepartment of Recreation and Sport Management, Shu-Te University, Kaohsiung, TaiwanDepartment of Orthopedics, Cishan Hospital, Ministry of Health and Welfare, Kaohsiung, TaiwanFunctional Neurosurgery Division, Neurological Institute, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli County, TaiwanCenter for Health Data Science Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, ChinaDepartment of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, ChinaInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan0Department of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan1Graduate Institute of Integrated Medicine, China Medical University, Taichung, TaiwanObjectives: The main purpose of this retrospective cohort study was to provide an evaluation of Ankylosing spondylitis (AS) patients' fibromyalgia risk in different age and sex subgroups by analyzing large study samples.Methods: Datasets from the National Taiwan Insurance Research Database (NHIRD) were retrieved in this retrospective cohort study. This study was approved by the Institutional Review Board of Chung Shan Medical University (IRB permit number CS15134). Within the Longitudinal Health Insurance Database (LHID), and the subset of NHIRD, we identified AS patients to explore the risk of further fibromyalgia. The exposure cohort included patients with newly-diagnosed AS (ICD-9-CM:720.0) during 2000–2013. After 1:4 age-sex matching and 1:2 propensity score matching, and adjusting potential confounders, individuals without AS were identified as a comparison cohort. The adjusted hazard ratio of subsequent development of fibromyalgia in people with AS was evaluated. Further stratification analyses of different ages and genders were then undertaken to validate the results.Results: In total, 17 088 individuals were included in the present study, including 5,696 patients with AS and 11,392 individuals without AS. Respective incidence rates (per 1,000 person-months) of fibromyalgia was 0.52 (95% CI, 0.46–0.59) in the AS cohort and 0.39 (95% CI, 0.35–0.44) in the non-AS cohort. Compared with the non-AS cohort, aHR of developing fibromyalgia was 1.32 (95% CI, 1.12–1.55) in people with AS. This association was consistent in both statistical models of 1:4 age–sex matching and 1:2 propensity score matching.Conclusion: Patients with AS were associated with a higher risk of fibromyalgia, especially those over 65 years old. In managing patients with AS, clinicians should be aware of this association, which could impact diagnosis, disease activity evaluation, and treatment.https://www.frontiersin.org/articles/10.3389/fmed.2021.618594/fullankylosing spondylitisfibromyalgiacohortpopulation-based studyNHIRD |
| spellingShingle | Shuo-Yan Gau Yung-Heng Lee Yung-Heng Lee Yung-Heng Lee Hsi-Kai Tsou Hsi-Kai Tsou Jing-Yang Huang Jing-Yang Huang Xinpeng Chen Zhizhong Ye James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study Frontiers in Medicine ankylosing spondylitis fibromyalgia cohort population-based study NHIRD |
| title | Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study |
| title_full | Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study |
| title_fullStr | Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study |
| title_full_unstemmed | Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study |
| title_short | Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study |
| title_sort | patients with ankylosing spondylitis are associated with high risk of fibromyalgia a nationwide population based cohort study |
| topic | ankylosing spondylitis fibromyalgia cohort population-based study NHIRD |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.618594/full |
| work_keys_str_mv | AT shuoyangau patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT yunghenglee patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT yunghenglee patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT yunghenglee patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT hsikaitsou patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT hsikaitsou patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT jingyanghuang patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT jingyanghuang patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT xinpengchen patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT zhizhongye patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT jameschengchungwei patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT jameschengchungwei patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy AT jameschengchungwei patientswithankylosingspondylitisareassociatedwithhighriskoffibromyalgiaanationwidepopulationbasedcohortstudy |