Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis

New pharmacologic advances in the treatment of diabetes include SGLT-2 inhibitors, which have been demonstrated in randomized-controlled clinical trials to reduce overall and cardiac-specific mortality and slow progression of chronic kidney disease. Euglycemic diabetic ketoacidosis is a rare but lif...

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Main Authors: Clara M. Gomez-Sanchez, MD, Bian X. Wu, MD, Jeffrey E. Gotts, MD, Robert W. Chang, MD
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Vascular Surgery Cases and Innovative Techniques
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2468428721001805
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author Clara M. Gomez-Sanchez, MD
Bian X. Wu, MD
Jeffrey E. Gotts, MD
Robert W. Chang, MD
author_facet Clara M. Gomez-Sanchez, MD
Bian X. Wu, MD
Jeffrey E. Gotts, MD
Robert W. Chang, MD
author_sort Clara M. Gomez-Sanchez, MD
collection DOAJ
description New pharmacologic advances in the treatment of diabetes include SGLT-2 inhibitors, which have been demonstrated in randomized-controlled clinical trials to reduce overall and cardiac-specific mortality and slow progression of chronic kidney disease. Euglycemic diabetic ketoacidosis is a rare but life-threatening complication associated with the use of SGLT-2 inhibitors. Here we describe a case of severe euglycemic diabetic ketoacidosis after lower extremity bypass in a patient taking an SGLT-2 inhibitor. Awareness of this potential complication is essential as these novel agents are increasingly used in patients with cardiovascular disease.
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spelling doaj.art-3006de9df1f84acda593c0de6bbb76002022-12-21T17:22:21ZengElsevierJournal of Vascular Surgery Cases and Innovative Techniques2468-42872021-12-0174778780Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosisClara M. Gomez-Sanchez, MD0Bian X. Wu, MD1Jeffrey E. Gotts, MD2Robert W. Chang, MD3Division of Vascular and Endovascular Surgery, Department of Surgery, University of California San Francisco, San Francisco, Calif; Correspondence: Clara M. Gomez-Sanchez, MD, University of California San Francisco, San Francisco, 400 Parnassus Ave, Ste A-581, San Francisco, CA 94143Department of Vascular Surgery, Kaiser Permanente Northern California, Oakland, CalifDepartment of Critical Care Medicine, Kaiser Permanente Northern California, Oakland, CalifDepartment of Vascular Surgery, Kaiser Permanente Northern California, Oakland, CalifNew pharmacologic advances in the treatment of diabetes include SGLT-2 inhibitors, which have been demonstrated in randomized-controlled clinical trials to reduce overall and cardiac-specific mortality and slow progression of chronic kidney disease. Euglycemic diabetic ketoacidosis is a rare but life-threatening complication associated with the use of SGLT-2 inhibitors. Here we describe a case of severe euglycemic diabetic ketoacidosis after lower extremity bypass in a patient taking an SGLT-2 inhibitor. Awareness of this potential complication is essential as these novel agents are increasingly used in patients with cardiovascular disease.http://www.sciencedirect.com/science/article/pii/S2468428721001805Peripheral artery diseaseDiabetic acidosisSGLT-2 inhibitorsPostoperative complication
spellingShingle Clara M. Gomez-Sanchez, MD
Bian X. Wu, MD
Jeffrey E. Gotts, MD
Robert W. Chang, MD
Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
Journal of Vascular Surgery Cases and Innovative Techniques
Peripheral artery disease
Diabetic acidosis
SGLT-2 inhibitors
Postoperative complication
title Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
title_full Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
title_fullStr Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
title_full_unstemmed Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
title_short Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
title_sort euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
topic Peripheral artery disease
Diabetic acidosis
SGLT-2 inhibitors
Postoperative complication
url http://www.sciencedirect.com/science/article/pii/S2468428721001805
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