Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020
BackgroundAlthough previous studies found that frailty is prevalent in NAFLD patients with advanced liver fibrosis and cirrhosis, studies examining the relationship are spare.AimOur study aspires to investigate the potential correlation between the Frailty Index (FI) and hepatic fibrosis among middl...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1330221/full |
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| author | Falide Atabieke Xiu-Juan Li Ailikamu Aierken Jian Li Yu Zhang Yierzhati Aizezi Hong-Liang Gao Zhi-Qiang Zhang |
| author_facet | Falide Atabieke Xiu-Juan Li Ailikamu Aierken Jian Li Yu Zhang Yierzhati Aizezi Hong-Liang Gao Zhi-Qiang Zhang |
| author_sort | Falide Atabieke |
| collection | DOAJ |
| description | BackgroundAlthough previous studies found that frailty is prevalent in NAFLD patients with advanced liver fibrosis and cirrhosis, studies examining the relationship are spare.AimOur study aspires to investigate the potential correlation between the Frailty Index (FI) and hepatic fibrosis among middle-aged and older adults with NAFLD.MethodsData from the 2017–2020.03 National Health and Nutrition Examination Survey (NHANES) were utilized for this study, with a final of 2,383 participants aged 50 years and older included. The quantification of frailty was executed employing a 49-item frailty index. The recognition of hepatic steatosis and fibrosis was accomplished through the utilization of the controlling attenuation parameter (CAP) and transient elastography (TE). The relationship between the FI and hepatic fibrosis were investigated employing univariable and multivariable-adjusted logistic regression analyses. A subgroup analysis was conducted, dividing the subjects based on gender, Body Mass Index (BMI), and the presence of hyperlipidemia.ResultsThe findings demonstrated a positive correlation between the FI and significant hepatic fibrosis in NAFLD, even after using multivariate logistic regression models adjusting for potential confounding factors (OR = 1.022, 95% CI, 1.004–1.041) and in tertiles (Q3vs Q1: OR = 2.004, 95% CI, 1.162–3.455). In the subgroup analysis, the correlation was more statistically significant in male (OR = 1.046, 95% CI, 1.022–1.071), under/normal weight (OR = 1.077, 95% CI, 1.009–1.150), overweight (OR = 1.040, 95% CI, 1.010–1.071), and subjects without hyperlipidemia (OR = 1.054, 95% CI, 1.012–1.097). The area under the Receiver Operating Characteristic (ROC) curve for the FI in assessing the existence of substantial fibrosis in NAFLD was 0.612 (95% CI, 0.596–0.628).ConclusionThis study demonstrated a positive correlation between significant hepatic fibrosis and frailty, particularly among males aged 50 years and older, who were non-obese and did not have hyperlipidemia with NAFLD. Additional studies are required to further validate these findings. |
| first_indexed | 2024-03-08T04:16:21Z |
| format | Article |
| id | doaj.art-30074d9863ba43fbb8f3b1b7caff6f27 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-08T04:16:21Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-30074d9863ba43fbb8f3b1b7caff6f272024-02-08T15:51:27ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-02-011210.3389/fpubh.2024.13302211330221Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020Falide Atabieke0Xiu-Juan Li1Ailikamu Aierken2Jian Li3Yu Zhang4Yierzhati Aizezi5Hong-Liang Gao6Zhi-Qiang Zhang7The Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaXinjiang Medical University School of Clinical Medicine, Children's Hospital of the Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaCenter of Critical Care Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaThe Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, ChinaBackgroundAlthough previous studies found that frailty is prevalent in NAFLD patients with advanced liver fibrosis and cirrhosis, studies examining the relationship are spare.AimOur study aspires to investigate the potential correlation between the Frailty Index (FI) and hepatic fibrosis among middle-aged and older adults with NAFLD.MethodsData from the 2017–2020.03 National Health and Nutrition Examination Survey (NHANES) were utilized for this study, with a final of 2,383 participants aged 50 years and older included. The quantification of frailty was executed employing a 49-item frailty index. The recognition of hepatic steatosis and fibrosis was accomplished through the utilization of the controlling attenuation parameter (CAP) and transient elastography (TE). The relationship between the FI and hepatic fibrosis were investigated employing univariable and multivariable-adjusted logistic regression analyses. A subgroup analysis was conducted, dividing the subjects based on gender, Body Mass Index (BMI), and the presence of hyperlipidemia.ResultsThe findings demonstrated a positive correlation between the FI and significant hepatic fibrosis in NAFLD, even after using multivariate logistic regression models adjusting for potential confounding factors (OR = 1.022, 95% CI, 1.004–1.041) and in tertiles (Q3vs Q1: OR = 2.004, 95% CI, 1.162–3.455). In the subgroup analysis, the correlation was more statistically significant in male (OR = 1.046, 95% CI, 1.022–1.071), under/normal weight (OR = 1.077, 95% CI, 1.009–1.150), overweight (OR = 1.040, 95% CI, 1.010–1.071), and subjects without hyperlipidemia (OR = 1.054, 95% CI, 1.012–1.097). The area under the Receiver Operating Characteristic (ROC) curve for the FI in assessing the existence of substantial fibrosis in NAFLD was 0.612 (95% CI, 0.596–0.628).ConclusionThis study demonstrated a positive correlation between significant hepatic fibrosis and frailty, particularly among males aged 50 years and older, who were non-obese and did not have hyperlipidemia with NAFLD. Additional studies are required to further validate these findings.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1330221/fullfrailtyhepatic fibrosisnon-alcoholic fatty liver diseasenational health and nutrition examination surveycontrolled attenuation parameter |
| spellingShingle | Falide Atabieke Xiu-Juan Li Ailikamu Aierken Jian Li Yu Zhang Yierzhati Aizezi Hong-Liang Gao Zhi-Qiang Zhang Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020 Frontiers in Public Health frailty hepatic fibrosis non-alcoholic fatty liver disease national health and nutrition examination survey controlled attenuation parameter |
| title | Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020 |
| title_full | Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020 |
| title_fullStr | Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020 |
| title_full_unstemmed | Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020 |
| title_short | Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017–2020 |
| title_sort | association between frailty and hepatic fibrosis in nafld among middle aged and older adults results from nhanes 2017 2020 |
| topic | frailty hepatic fibrosis non-alcoholic fatty liver disease national health and nutrition examination survey controlled attenuation parameter |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1330221/full |
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