BMP antagonists in tissue development and disease
Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists repres...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
|
| Series: | Matrix Biology Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590028521000156 |
| _version_ | 1818916135777599488 |
|---|---|
| author | Annkatrin Correns Laura-Marie A. Zimmermann Clair Baldock Gerhard Sengle |
| author_facet | Annkatrin Correns Laura-Marie A. Zimmermann Clair Baldock Gerhard Sengle |
| author_sort | Annkatrin Correns |
| collection | DOAJ |
| description | Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists represents the most intensively studied mechanistic concept of BMP growth factor regulation. It was shown to be critical for numerous developmental programs, including germ layer specification and spatiotemporal gradients required for the establishment of the dorsal–ventral axis and organ formation. The importance of BMP antagonists for extracellular matrix homeostasis is illustrated by the numerous human connective tissue disorders caused by their mutational inactivation. Here, we will focus on the known functional interactions targeting BMP antagonists to the ECM and discuss how these interactions influence BMP antagonist activity. Moreover, we will provide an overview about the current concepts and investigated molecular mechanisms modulating BMP inhibitor function in the context of development and disease. |
| first_indexed | 2024-12-20T00:13:22Z |
| format | Article |
| id | doaj.art-300888ed5fc147cdacf0827a0d134b30 |
| institution | Directory Open Access Journal |
| issn | 2590-0285 |
| language | English |
| last_indexed | 2024-12-20T00:13:22Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Matrix Biology Plus |
| spelling | doaj.art-300888ed5fc147cdacf0827a0d134b302022-12-21T20:00:27ZengElsevierMatrix Biology Plus2590-02852021-08-0111100071BMP antagonists in tissue development and diseaseAnnkatrin Correns0Laura-Marie A. Zimmermann1Clair Baldock2Gerhard Sengle3Department of Paediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Center for Biochemistry, Faculty of Medicine, University Hospital of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, GermanyDepartment of Paediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Center for Biochemistry, Faculty of Medicine, University Hospital of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, GermanyWellcome Trust Centre for Cell-Matrix Research, University of Manchester, B.3016 Michael Smith Building, Oxford Road, M13 9PT, Manchester, United Kingdom; Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Michael Smith Building, M13 9PT, Manchester, UKDepartment of Paediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Center for Biochemistry, Faculty of Medicine, University Hospital of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany; Cologne Centre for Musculoskeletal Biomechanics (CCMB), Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany; Corresponding author at: Center for Biochemistry, Faculty of Medicine, University Hospital of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany.Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists represents the most intensively studied mechanistic concept of BMP growth factor regulation. It was shown to be critical for numerous developmental programs, including germ layer specification and spatiotemporal gradients required for the establishment of the dorsal–ventral axis and organ formation. The importance of BMP antagonists for extracellular matrix homeostasis is illustrated by the numerous human connective tissue disorders caused by their mutational inactivation. Here, we will focus on the known functional interactions targeting BMP antagonists to the ECM and discuss how these interactions influence BMP antagonist activity. Moreover, we will provide an overview about the current concepts and investigated molecular mechanisms modulating BMP inhibitor function in the context of development and disease.http://www.sciencedirect.com/science/article/pii/S2590028521000156Bone morphogenetic protein (BMP)BMP antagonistsExtracellular matrix (ECM)Connective tissue disorder |
| spellingShingle | Annkatrin Correns Laura-Marie A. Zimmermann Clair Baldock Gerhard Sengle BMP antagonists in tissue development and disease Matrix Biology Plus Bone morphogenetic protein (BMP) BMP antagonists Extracellular matrix (ECM) Connective tissue disorder |
| title | BMP antagonists in tissue development and disease |
| title_full | BMP antagonists in tissue development and disease |
| title_fullStr | BMP antagonists in tissue development and disease |
| title_full_unstemmed | BMP antagonists in tissue development and disease |
| title_short | BMP antagonists in tissue development and disease |
| title_sort | bmp antagonists in tissue development and disease |
| topic | Bone morphogenetic protein (BMP) BMP antagonists Extracellular matrix (ECM) Connective tissue disorder |
| url | http://www.sciencedirect.com/science/article/pii/S2590028521000156 |
| work_keys_str_mv | AT annkatrincorrens bmpantagonistsintissuedevelopmentanddisease AT lauramarieazimmermann bmpantagonistsintissuedevelopmentanddisease AT clairbaldock bmpantagonistsintissuedevelopmentanddisease AT gerhardsengle bmpantagonistsintissuedevelopmentanddisease |