CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP
ABSTRACT Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences. Methods: This prospective observational study of 66 patients with a 2-year f...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2023-04-01
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| Series: | Acta Ortopédica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522023000200208&lng=en&tlng=en |
| _version_ | 1797844849797365760 |
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| author | Morena Anna Basso Alessio Bernasconi Giovanni Balato Andrea Cozzolino Giulia Famiglietti Francesco Smeraglia |
| author_facet | Morena Anna Basso Alessio Bernasconi Giovanni Balato Andrea Cozzolino Giulia Famiglietti Francesco Smeraglia |
| author_sort | Morena Anna Basso |
| collection | DOAJ |
| description | ABSTRACT Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences. Methods: This prospective observational study of 66 patients with a 2-year follow-up. Patients with an extension lag major of 20° at the metacarpophalangeal joint (MPJ) and/or proximal interphalangeal joint (PIPJ) were included. We collected data on demographic and anamnestic details, MPJ and PIPJ contracture degrees, DASH score, complications, and recurrences. Results: The mean pre-injection contracture was 34° for MPJ and 31° for PIPJ. At the 2-year follow-up, the mean contracture for the MPJ and PIPJ were respectively 3° and 14.5°. The mean DASH score decreased from 21.8 before injection to 10,4 after 2 years. The disease recurrence occurred in 34.8% of the patients, all with PIPJ contracture. The main complication was skin breakage (25.7%). Conclusion: The CCH injections remain a consistent option in treating DD; withdrawal from the European market deprives surgeons and patients of low invasiveness and safe tool for treating DD. Level of evidence IV, Therapeutic study investigating treatment results, Case series. |
| first_indexed | 2024-04-09T17:29:01Z |
| format | Article |
| id | doaj.art-300c56c4bca340368528977d7b3a8012 |
| institution | Directory Open Access Journal |
| issn | 1413-7852 |
| language | English |
| last_indexed | 2024-04-09T17:29:01Z |
| publishDate | 2023-04-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Acta Ortopédica Brasileira |
| spelling | doaj.art-300c56c4bca340368528977d7b3a80122023-04-18T07:33:05ZengSociedade Brasileira de Ortopedia e TraumatologiaActa Ortopédica Brasileira1413-78522023-04-0131spe110.1590/1413-785220233101e259218CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UPMorena Anna Bassohttps://orcid.org/0000-0003-3771-4149Alessio Bernasconihttps://orcid.org/0000-0002-9427-3178Giovanni Balatohttps://orcid.org/0000-0002-0392-4511Andrea Cozzolinohttps://orcid.org/0000-0001-6044-5907Giulia Famigliettihttps://orcid.org/0000-0002-2305-8091Francesco Smeragliahttps://orcid.org/0000-0002-3134-0425ABSTRACT Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences. Methods: This prospective observational study of 66 patients with a 2-year follow-up. Patients with an extension lag major of 20° at the metacarpophalangeal joint (MPJ) and/or proximal interphalangeal joint (PIPJ) were included. We collected data on demographic and anamnestic details, MPJ and PIPJ contracture degrees, DASH score, complications, and recurrences. Results: The mean pre-injection contracture was 34° for MPJ and 31° for PIPJ. At the 2-year follow-up, the mean contracture for the MPJ and PIPJ were respectively 3° and 14.5°. The mean DASH score decreased from 21.8 before injection to 10,4 after 2 years. The disease recurrence occurred in 34.8% of the patients, all with PIPJ contracture. The main complication was skin breakage (25.7%). Conclusion: The CCH injections remain a consistent option in treating DD; withdrawal from the European market deprives surgeons and patients of low invasiveness and safe tool for treating DD. Level of evidence IV, Therapeutic study investigating treatment results, Case series.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522023000200208&lng=en&tlng=enDupuytren ContracturePalmar FibromatosisMicrobial CollagenaseRecurrence |
| spellingShingle | Morena Anna Basso Alessio Bernasconi Giovanni Balato Andrea Cozzolino Giulia Famiglietti Francesco Smeraglia CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP Acta Ortopédica Brasileira Dupuytren Contracture Palmar Fibromatosis Microbial Collagenase Recurrence |
| title | CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP |
| title_full | CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP |
| title_fullStr | CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP |
| title_full_unstemmed | CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP |
| title_short | CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP |
| title_sort | clinical results of collagenase treatment for dupuytren s disease a case series study with 2 years follow up |
| topic | Dupuytren Contracture Palmar Fibromatosis Microbial Collagenase Recurrence |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522023000200208&lng=en&tlng=en |
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