The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury
Traumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually. Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Nanotheranostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-845X/2/4/14 |
| _version_ | 1797503234444623872 |
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| author | Brandon Z. McDonald Connor C. Gee Forrest M. Kievit |
| author_facet | Brandon Z. McDonald Connor C. Gee Forrest M. Kievit |
| author_sort | Brandon Z. McDonald |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually. Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanism and frequency of injury. Previous literature has investigated this relationship through the development of animal models and behavioral tasks. However, recent advancements in these methods may provide insight into the translation of therapeutics into a clinical setting. In this review, we characterize various animal models and behavioral tasks to provide guidelines for evaluating the therapeutic efficacy of treatment options in TBI. We provide a brief review into the systems utilized in TBI classification and provide comparisons to the animal models that have been developed. In addition, we discuss the role of behavioral tasks in evaluating outcomes associated with TBI. Our goal is to provide those in the nanotheranostic field a guide for selecting an adequate TBI animal model and behavioral task for assessment of outcomes to increase research in this field. |
| first_indexed | 2024-03-10T03:47:38Z |
| format | Article |
| id | doaj.art-300d78f1a37a41d0abb2fb5413324051 |
| institution | Directory Open Access Journal |
| issn | 2624-845X |
| language | English |
| last_indexed | 2024-03-10T03:47:38Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Nanotheranostics |
| spelling | doaj.art-300d78f1a37a41d0abb2fb54133240512023-11-23T09:04:21ZengMDPI AGJournal of Nanotheranostics2624-845X2021-12-012422426810.3390/jnt2040014The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain InjuryBrandon Z. McDonald0Connor C. Gee1Forrest M. Kievit2Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583-0726, USADepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583-0726, USADepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583-0726, USATraumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually. Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanism and frequency of injury. Previous literature has investigated this relationship through the development of animal models and behavioral tasks. However, recent advancements in these methods may provide insight into the translation of therapeutics into a clinical setting. In this review, we characterize various animal models and behavioral tasks to provide guidelines for evaluating the therapeutic efficacy of treatment options in TBI. We provide a brief review into the systems utilized in TBI classification and provide comparisons to the animal models that have been developed. In addition, we discuss the role of behavioral tasks in evaluating outcomes associated with TBI. Our goal is to provide those in the nanotheranostic field a guide for selecting an adequate TBI animal model and behavioral task for assessment of outcomes to increase research in this field.https://www.mdpi.com/2624-845X/2/4/14neurotraumananoparticleneurobehavior |
| spellingShingle | Brandon Z. McDonald Connor C. Gee Forrest M. Kievit The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury Journal of Nanotheranostics neurotrauma nanoparticle neurobehavior |
| title | The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury |
| title_full | The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury |
| title_fullStr | The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury |
| title_full_unstemmed | The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury |
| title_short | The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury |
| title_sort | nanotheranostic researcher s guide for use of animal models of traumatic brain injury |
| topic | neurotrauma nanoparticle neurobehavior |
| url | https://www.mdpi.com/2624-845X/2/4/14 |
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