Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives
The treatment of unresectable or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) has traditionally relied on chemotherapy or radiotherapy, yielding suboptimal outcomes. The introduction of immunotherapy has significantly improved HNSCC treatment, even if the long-term results cannot be defi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/11/577 |
| _version_ | 1827640193208811520 |
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| author | Piero Giuseppe Meliante Carla Petrella Marco Fiore Antonio Minni Christian Barbato |
| author_facet | Piero Giuseppe Meliante Carla Petrella Marco Fiore Antonio Minni Christian Barbato |
| author_sort | Piero Giuseppe Meliante |
| collection | DOAJ |
| description | The treatment of unresectable or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) has traditionally relied on chemotherapy or radiotherapy, yielding suboptimal outcomes. The introduction of immunotherapy has significantly improved HNSCC treatment, even if the long-term results cannot be defined as satisfactory. Its mechanism of action aims to counteract the blockade of tumor immune escape. This result can also be obtained by stimulating the immune system with vaccines. This review scope is to comprehensively gather existing evidence and summarize ongoing clinical trials focused on therapeutic vaccines for HNSCC treatment. The current landscape reveals numerous promising drugs in the early stages of experimentation, along with a multitude of trials that have been suspended or abandoned for years. Nonetheless, there are encouraging results and ongoing experiments that instill hope for potential paradigm shifts in HNSCC therapy. |
| first_indexed | 2024-03-09T16:55:30Z |
| format | Article |
| id | doaj.art-300fec750180461899e5d77e6c88a39f |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T16:55:30Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-300fec750180461899e5d77e6c88a39f2023-11-24T14:36:12ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-11-0145119215923310.3390/cimb45110577Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and PerspectivesPiero Giuseppe Meliante0Carla Petrella1Marco Fiore2Antonio Minni3Christian Barbato4Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyThe treatment of unresectable or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) has traditionally relied on chemotherapy or radiotherapy, yielding suboptimal outcomes. The introduction of immunotherapy has significantly improved HNSCC treatment, even if the long-term results cannot be defined as satisfactory. Its mechanism of action aims to counteract the blockade of tumor immune escape. This result can also be obtained by stimulating the immune system with vaccines. This review scope is to comprehensively gather existing evidence and summarize ongoing clinical trials focused on therapeutic vaccines for HNSCC treatment. The current landscape reveals numerous promising drugs in the early stages of experimentation, along with a multitude of trials that have been suspended or abandoned for years. Nonetheless, there are encouraging results and ongoing experiments that instill hope for potential paradigm shifts in HNSCC therapy.https://www.mdpi.com/1467-3045/45/11/577head and neck squamous cell carcinoma (HNSCC)therapeutic cancer vaccineEpstein–Barr virus (EBV)human papilloma virus (HPV)mRNA vaccine |
| spellingShingle | Piero Giuseppe Meliante Carla Petrella Marco Fiore Antonio Minni Christian Barbato Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives Current Issues in Molecular Biology head and neck squamous cell carcinoma (HNSCC) therapeutic cancer vaccine Epstein–Barr virus (EBV) human papilloma virus (HPV) mRNA vaccine |
| title | Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives |
| title_full | Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives |
| title_fullStr | Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives |
| title_full_unstemmed | Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives |
| title_short | Head and Neck Squamous Cell Carcinoma Vaccine: Current Landscape and Perspectives |
| title_sort | head and neck squamous cell carcinoma vaccine current landscape and perspectives |
| topic | head and neck squamous cell carcinoma (HNSCC) therapeutic cancer vaccine Epstein–Barr virus (EBV) human papilloma virus (HPV) mRNA vaccine |
| url | https://www.mdpi.com/1467-3045/45/11/577 |
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