Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles
The mammalian ovary has two main functions—producing mature oocytes for fertilization and secreting hormones for maintaining the ovarian endocrine functions. Both functions are vital for female reproduction. Primordial follicles are composed of flattened pre-granulosa cells and a primary oocyte, and...
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1491 |
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| author | Yu Zhao Haiwei Feng Yihui Zhang Jian V. Zhang Xiaohui Wang Dongteng Liu Tianren Wang Raymond H. W. Li Ernest H. Y. Ng William S. B. Yeung Kenny A. Rodriguez-Wallberg Kui Liu |
| author_facet | Yu Zhao Haiwei Feng Yihui Zhang Jian V. Zhang Xiaohui Wang Dongteng Liu Tianren Wang Raymond H. W. Li Ernest H. Y. Ng William S. B. Yeung Kenny A. Rodriguez-Wallberg Kui Liu |
| author_sort | Yu Zhao |
| collection | DOAJ |
| description | The mammalian ovary has two main functions—producing mature oocytes for fertilization and secreting hormones for maintaining the ovarian endocrine functions. Both functions are vital for female reproduction. Primordial follicles are composed of flattened pre-granulosa cells and a primary oocyte, and activation of primordial follicles is the first step in follicular development and is the key factor in determining the reproductive capacity of females. The recent identification of the phosphatidylinositol 3 kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling pathway as the key controller for follicular activation has made the study of primordial follicle activation a hot research topic in the field of reproduction. This review systematically summarizes the roles of the PI3K/PTEN signaling pathway in primordial follicle activation and discusses how the pathway interacts with various other molecular networks to control follicular activation. Studies on the activation of primordial follicles have led to the development of methods for the in vitro activation of primordial follicles as a treatment for infertility in women with premature ovarian insufficiency or poor ovarian response, and these are also discussed along with some practical applications of our current knowledge of follicular activation. |
| first_indexed | 2024-03-10T10:26:07Z |
| format | Article |
| id | doaj.art-30103ca7963043f99f62d6dcc77ebe18 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:26:07Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-30103ca7963043f99f62d6dcc77ebe182023-11-21T23:59:03ZengMDPI AGCells2073-44092021-06-01106149110.3390/cells10061491Current Understandings of Core Pathways for the Activation of Mammalian Primordial FolliclesYu Zhao0Haiwei Feng1Yihui Zhang2Jian V. Zhang3Xiaohui Wang4Dongteng Liu5Tianren Wang6Raymond H. W. Li7Ernest H. Y. Ng8William S. B. Yeung9Kenny A. Rodriguez-Wallberg10Kui Liu11Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaDepartment of Oncology-Pathology, Karolinska Institutet, 14186 Stockholm, SwedenShenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Haiyuan First Road 1, Shenzhen 518053, ChinaThe mammalian ovary has two main functions—producing mature oocytes for fertilization and secreting hormones for maintaining the ovarian endocrine functions. Both functions are vital for female reproduction. Primordial follicles are composed of flattened pre-granulosa cells and a primary oocyte, and activation of primordial follicles is the first step in follicular development and is the key factor in determining the reproductive capacity of females. The recent identification of the phosphatidylinositol 3 kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling pathway as the key controller for follicular activation has made the study of primordial follicle activation a hot research topic in the field of reproduction. This review systematically summarizes the roles of the PI3K/PTEN signaling pathway in primordial follicle activation and discusses how the pathway interacts with various other molecular networks to control follicular activation. Studies on the activation of primordial follicles have led to the development of methods for the in vitro activation of primordial follicles as a treatment for infertility in women with premature ovarian insufficiency or poor ovarian response, and these are also discussed along with some practical applications of our current knowledge of follicular activation.https://www.mdpi.com/2073-4409/10/6/1491primordial folliclesPI3K/PTEN signalingin vitro activationoocytegranulosa cellsfertilization |
| spellingShingle | Yu Zhao Haiwei Feng Yihui Zhang Jian V. Zhang Xiaohui Wang Dongteng Liu Tianren Wang Raymond H. W. Li Ernest H. Y. Ng William S. B. Yeung Kenny A. Rodriguez-Wallberg Kui Liu Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles Cells primordial follicles PI3K/PTEN signaling in vitro activation oocyte granulosa cells fertilization |
| title | Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles |
| title_full | Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles |
| title_fullStr | Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles |
| title_full_unstemmed | Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles |
| title_short | Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles |
| title_sort | current understandings of core pathways for the activation of mammalian primordial follicles |
| topic | primordial follicles PI3K/PTEN signaling in vitro activation oocyte granulosa cells fertilization |
| url | https://www.mdpi.com/2073-4409/10/6/1491 |
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