Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report
<p>Abstract</p> <p>Introduction</p> <p>Circumscript, progressing lipoatrophy at the insulin injection sites is an unexplained, however rare condition in diabetes mellitus.</p> <p>Case presentation</p> <p>We report a case of severe localised lipoa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-12-01
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| Series: | Diabetology & Metabolic Syndrome |
| Online Access: | http://www.dmsjournal.com/content/3/1/33 |
| _version_ | 1818515266954330112 |
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| author | Chantelau Ernst A Praetor Ruth Praetor Jörg Poll Ludger W |
| author_facet | Chantelau Ernst A Praetor Ruth Praetor Jörg Poll Ludger W |
| author_sort | Chantelau Ernst A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Circumscript, progressing lipoatrophy at the insulin injection sites is an unexplained, however rare condition in diabetes mellitus.</p> <p>Case presentation</p> <p>We report a case of severe localised lipoatrophy developing during insulin pump-treatment (continuous subcutaneous insulin infusion) with the insulin analogue lispro (Humalog<sup>®</sup>) in a woman with type-1 diabetes mellitus. After 11 months of progressing lipoatrophy at two spots on the abdomen, low-dose prednisone (5-10 mg) p.o. was given at breakfast for 8 months, whereby the atrophic lesions centripetally re-filled with subcutaneous fat tissue (confirmed by MRI) despite ongoing use of insulin lispro. However, 4 weeks after cessation of prednisone, lipoatrophy relapsed, but resolved after another 2 months of low-dose prednisone. No further relapse was noted during 12 months of follow-up on insulin-pump therapy with Humalog<sup>®</sup>.</p> <p>Conclusion</p> <p>Consistent with an assumed inflammatory nature of the condition, low-dose oral prednisone appeared to have cured the lipoatrophic reaction in our patient. Our observation suggests a temporary intolerance of the subcutaneous fat tissue to insulin lispro (Humalog<sup>®</sup>), triggered by an unknown endogenous mechanism.</p> |
| first_indexed | 2024-12-11T00:26:47Z |
| format | Article |
| id | doaj.art-301065af45be464aa09e05c553bf64b0 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-11T00:26:47Z |
| publishDate | 2011-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-301065af45be464aa09e05c553bf64b02022-12-22T01:27:31ZengBMCDiabetology & Metabolic Syndrome1758-59962011-12-01313310.1186/1758-5996-3-33Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case reportChantelau Ernst APraetor RuthPraetor JörgPoll Ludger W<p>Abstract</p> <p>Introduction</p> <p>Circumscript, progressing lipoatrophy at the insulin injection sites is an unexplained, however rare condition in diabetes mellitus.</p> <p>Case presentation</p> <p>We report a case of severe localised lipoatrophy developing during insulin pump-treatment (continuous subcutaneous insulin infusion) with the insulin analogue lispro (Humalog<sup>®</sup>) in a woman with type-1 diabetes mellitus. After 11 months of progressing lipoatrophy at two spots on the abdomen, low-dose prednisone (5-10 mg) p.o. was given at breakfast for 8 months, whereby the atrophic lesions centripetally re-filled with subcutaneous fat tissue (confirmed by MRI) despite ongoing use of insulin lispro. However, 4 weeks after cessation of prednisone, lipoatrophy relapsed, but resolved after another 2 months of low-dose prednisone. No further relapse was noted during 12 months of follow-up on insulin-pump therapy with Humalog<sup>®</sup>.</p> <p>Conclusion</p> <p>Consistent with an assumed inflammatory nature of the condition, low-dose oral prednisone appeared to have cured the lipoatrophic reaction in our patient. Our observation suggests a temporary intolerance of the subcutaneous fat tissue to insulin lispro (Humalog<sup>®</sup>), triggered by an unknown endogenous mechanism.</p>http://www.dmsjournal.com/content/3/1/33 |
| spellingShingle | Chantelau Ernst A Praetor Ruth Praetor Jörg Poll Ludger W Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report Diabetology & Metabolic Syndrome |
| title | Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report |
| title_full | Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report |
| title_fullStr | Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report |
| title_full_unstemmed | Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report |
| title_short | Relapsing insulin-induced lipoatrophy, cured by prolonged low-dose oral prednisone: a case report |
| title_sort | relapsing insulin induced lipoatrophy cured by prolonged low dose oral prednisone a case report |
| url | http://www.dmsjournal.com/content/3/1/33 |
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