PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study
Context: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2020;volume=31;issue=2;spage=277;epage=281;aulast=Lavanya |
| _version_ | 1828398067881082880 |
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| author | A Lavanya Wafa Khan Preeti Singh Dominic Augustine Roopa S Rao S V Sowmya Vanishri C Haragannavar K Shwetha Nambiar |
| author_facet | A Lavanya Wafa Khan Preeti Singh Dominic Augustine Roopa S Rao S V Sowmya Vanishri C Haragannavar K Shwetha Nambiar |
| author_sort | A Lavanya |
| collection | DOAJ |
| description | Context: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion molecules (VAMs). Aim: The aim of this study was to evaluate the expression of VAM (PECAM-1) in OLP. Setting and Design: Tissue samples involved 20 archival cases of histopathologically confirmed OLP (n = 15) and normal mucosa (n = 5) as controls. Materials and Methods: The sections were subjected to immunohistochemical analysis using antibody to PECAM-1. Brown staining of the endothelial cells of blood vessels was considered positive. The expression of PECAM-1 in OLP was statistically analyzed using Wilcoxon sign-rank test. Results: The expression of PECAM-1 in OLP was statistically significant when compared with normal mucosa (P < 0.05). A statistically significant difference was also observed in PECAM-1 expression between the reticular type and erosive type of OLP. Conclusion: PECAM-1 was found to be overexpressed in OLP; difference in PECAM-1 expression was noted between the reticular and erosive types. The VAMs could be exploited as a possible therapeutic target in OLP to modulate the disease process thereby reducing the dependency on corticosteroids. |
| first_indexed | 2024-12-10T08:55:50Z |
| format | Article |
| id | doaj.art-3010c4f528f647b995fe8308d235b283 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-10T08:55:50Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-3010c4f528f647b995fe8308d235b2832022-12-22T01:55:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032020-01-0131227728110.4103/ijdr.IJDR_653_18PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot studyA LavanyaWafa KhanPreeti SinghDominic AugustineRoopa S RaoS V SowmyaVanishri C HaragannavarK Shwetha NambiarContext: The etiopathogenesis of oral lichen planus (OLP) is still debatable. According to literature, many studies have illustrated OLP as a T-cell-mediated chronic autoimmune disease. Currently, there is increased evidence of chronic inflammation in OLP and its association with vascular adhesion molecules (VAMs). Aim: The aim of this study was to evaluate the expression of VAM (PECAM-1) in OLP. Setting and Design: Tissue samples involved 20 archival cases of histopathologically confirmed OLP (n = 15) and normal mucosa (n = 5) as controls. Materials and Methods: The sections were subjected to immunohistochemical analysis using antibody to PECAM-1. Brown staining of the endothelial cells of blood vessels was considered positive. The expression of PECAM-1 in OLP was statistically analyzed using Wilcoxon sign-rank test. Results: The expression of PECAM-1 in OLP was statistically significant when compared with normal mucosa (P < 0.05). A statistically significant difference was also observed in PECAM-1 expression between the reticular type and erosive type of OLP. Conclusion: PECAM-1 was found to be overexpressed in OLP; difference in PECAM-1 expression was noted between the reticular and erosive types. The VAMs could be exploited as a possible therapeutic target in OLP to modulate the disease process thereby reducing the dependency on corticosteroids.http://www.ijdr.in/article.asp?issn=0970-9290;year=2020;volume=31;issue=2;spage=277;epage=281;aulast=Lavanyainflammationoral lichen planuspecam-1vascular adhesion molecules |
| spellingShingle | A Lavanya Wafa Khan Preeti Singh Dominic Augustine Roopa S Rao S V Sowmya Vanishri C Haragannavar K Shwetha Nambiar PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study Indian Journal of Dental Research inflammation oral lichen planus pecam-1 vascular adhesion molecules |
| title | PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study |
| title_full | PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study |
| title_fullStr | PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study |
| title_full_unstemmed | PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study |
| title_short | PECAM-1 overexpression signifies aggressive biologic behavior of oral lichen planus – A pilot study |
| title_sort | pecam 1 overexpression signifies aggressive biologic behavior of oral lichen planus a pilot study |
| topic | inflammation oral lichen planus pecam-1 vascular adhesion molecules |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2020;volume=31;issue=2;spage=277;epage=281;aulast=Lavanya |
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