Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit clinical translation. We modify endogenous dyn...

Full description

Bibliographic Details
Main Authors: Rink-Jan Lohman, Karnaker Reddy Tupally, Ajit Kandale, Peter J. Cabot, Harendra S. Parekh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
dynorphin
kappa opioid receptors
biased agonists
non-addictive
pain treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1150313/full

Similar Items

Similar Items