Gut microbiota in Parkinson’s disease patients: hospital-based study
Abstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to describe the pattern of gut microbiota and its association with PD and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-021-00407-z |
| _version_ | 1818934526939758592 |
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| author | Eman M. Khedr Anwar M. Ali Enas Deaf Hebatallah M. Hassan Ahmed Alaa Ayman Gamea |
| author_facet | Eman M. Khedr Anwar M. Ali Enas Deaf Hebatallah M. Hassan Ahmed Alaa Ayman Gamea |
| author_sort | Eman M. Khedr |
| collection | DOAJ |
| description | Abstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to describe the pattern of gut microbiota and its association with PD and identify the effect of environmental factors on gut microbiota. This case–control study included 46 patients diagnosed as Parkinson’s disease (PD) and 31 healthy volunteers age and sex matched. Detailed history including age of onset, duration of disease, environmental risk factors, diet data, treatment, Unified Parkinson’s Disease Rating Scale (UPDRS), and gastrointestinal tract (GIT) domain of Non‐Motor Symptoms Scale (NMSS) were assessed. After extraction of bacterial DNA from the fecal samples, bacterial abundance was quantified by qPCR using 16S rRNA group-specific primers. Results Significant high abundance of Clostridium cluster IV, Akkermansia, Bifidobacterium, and lactic acid bacteria were found in the PD group compared with the control group (P < 0.001, 0.04, 0.02 and < 0.001, respectively), while Firmicutes were significantly less abundant in the PD group (P < 0.001) compared with the control group. The naive PD patients had significant abundance of Bifidobacterium, and lactic acid compared with control group. Interestingly, Akkermansia was more abundant in treated than untreated patients. There were significant associations between pesticide exposure and Bifidobacterium (P = 0.002), while no significant correlations between different gut microbiota and demographic, environment data, different rating scores or dominant type of PD. There was a significant negative correlation between the Bifidobacterium with the duration of illness (P = 0.012). Conclusion The present study highlighted a significant connection between PD and levels of certain types of gut microbiota, in support of a possible link between gut microbiota and a neurodegenerative cascade of PD. |
| first_indexed | 2024-12-20T05:05:41Z |
| format | Article |
| id | doaj.art-3015efca1fe3486495ce07b83d474343 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-20T05:05:41Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-3015efca1fe3486495ce07b83d4743432022-12-21T19:52:24ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292021-11-015711910.1186/s41983-021-00407-zGut microbiota in Parkinson’s disease patients: hospital-based studyEman M. Khedr0Anwar M. Ali1Enas Deaf2Hebatallah M. Hassan3Ahmed Alaa4Ayman Gamea5Department of Neuropsychiatry, Assiut University Hospital, Faculty of MedicineDepartment of Neuropsychiatry, Assiut University Hospital, Faculty of MedicineDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut UniversityDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut UniversityDepartment of Neuropsychiatry, Assiut University Hospital, Faculty of MedicineDepartment of Neuropsychiatry, South Valley University HospitalAbstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to describe the pattern of gut microbiota and its association with PD and identify the effect of environmental factors on gut microbiota. This case–control study included 46 patients diagnosed as Parkinson’s disease (PD) and 31 healthy volunteers age and sex matched. Detailed history including age of onset, duration of disease, environmental risk factors, diet data, treatment, Unified Parkinson’s Disease Rating Scale (UPDRS), and gastrointestinal tract (GIT) domain of Non‐Motor Symptoms Scale (NMSS) were assessed. After extraction of bacterial DNA from the fecal samples, bacterial abundance was quantified by qPCR using 16S rRNA group-specific primers. Results Significant high abundance of Clostridium cluster IV, Akkermansia, Bifidobacterium, and lactic acid bacteria were found in the PD group compared with the control group (P < 0.001, 0.04, 0.02 and < 0.001, respectively), while Firmicutes were significantly less abundant in the PD group (P < 0.001) compared with the control group. The naive PD patients had significant abundance of Bifidobacterium, and lactic acid compared with control group. Interestingly, Akkermansia was more abundant in treated than untreated patients. There were significant associations between pesticide exposure and Bifidobacterium (P = 0.002), while no significant correlations between different gut microbiota and demographic, environment data, different rating scores or dominant type of PD. There was a significant negative correlation between the Bifidobacterium with the duration of illness (P = 0.012). Conclusion The present study highlighted a significant connection between PD and levels of certain types of gut microbiota, in support of a possible link between gut microbiota and a neurodegenerative cascade of PD.https://doi.org/10.1186/s41983-021-00407-zGut microbiotaParkinson’s diseaseGIT domain non‐motor symptoms |
| spellingShingle | Eman M. Khedr Anwar M. Ali Enas Deaf Hebatallah M. Hassan Ahmed Alaa Ayman Gamea Gut microbiota in Parkinson’s disease patients: hospital-based study The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Gut microbiota Parkinson’s disease GIT domain non‐motor symptoms |
| title | Gut microbiota in Parkinson’s disease patients: hospital-based study |
| title_full | Gut microbiota in Parkinson’s disease patients: hospital-based study |
| title_fullStr | Gut microbiota in Parkinson’s disease patients: hospital-based study |
| title_full_unstemmed | Gut microbiota in Parkinson’s disease patients: hospital-based study |
| title_short | Gut microbiota in Parkinson’s disease patients: hospital-based study |
| title_sort | gut microbiota in parkinson s disease patients hospital based study |
| topic | Gut microbiota Parkinson’s disease GIT domain non‐motor symptoms |
| url | https://doi.org/10.1186/s41983-021-00407-z |
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