The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens
Abstract The coinfection of ALVs (ALV-J plus ALV-A or/and ALV-B) has played an important role in the incidence of tumors recently found in China in local breeds of yellow chickens. The study aims to obtain a better knowledge of the function and relevance of ALV coinfection in the clinical disease of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-024-03896-1 |
| _version_ | 1797274287126609920 |
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| author | Peikun Wang Jing Wang Na Wang Cong Xue Zhaoqing Han |
| author_facet | Peikun Wang Jing Wang Na Wang Cong Xue Zhaoqing Han |
| author_sort | Peikun Wang |
| collection | DOAJ |
| description | Abstract The coinfection of ALVs (ALV-J plus ALV-A or/and ALV-B) has played an important role in the incidence of tumors recently found in China in local breeds of yellow chickens. The study aims to obtain a better knowledge of the function and relevance of ALV coinfection in the clinical disease of avian leukosis, as well as its unique effect on the pathogenicity in Three-yellow chickens. One-day-old Three-yellow chicks (one day old) were infected with ALV-A, ALV-B, and ALV-J mono-infections, as well as ALV-A + J, ALV-B + J, and ALV-A + B + J coinfections, via intraperitoneal injection, and the chicks were then grown in isolators until they were 15 weeks old. The parameters, including the suppression of body weight gain, immune organ weight, viremia, histopathological changes and tumor incidence, were observed and compared with those of the uninfected control birds. The results demonstrated that coinfection with ALVs could induce more serious suppression of body weight gain (P < 0.05), damage to immune organs (P < 0.05) and higher tumor incidences than monoinfection, with triple infection producing the highest pathogenicity. The emergence of visible tumors and viremia occurred faster in the coinfected birds than in the monoinfected birds. These findings demonstrated that ALV coinfection resulted in considerably severe pathogenic and immunosuppressive consequences. |
| first_indexed | 2024-03-07T14:56:14Z |
| format | Article |
| id | doaj.art-301674f5c37c47c9a703105f28212bc0 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-03-07T14:56:14Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-301674f5c37c47c9a703105f28212bc02024-03-05T19:24:53ZengBMCBMC Veterinary Research1746-61482024-02-012011610.1186/s12917-024-03896-1The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickensPeikun Wang0Jing Wang1Na Wang2Cong Xue3Zhaoqing Han4Institute of Microbe and Host Health, Linyi UniversityAnimal Epidemic Disease Anticipatory Control CenterInstitute of Microbe and Host Health, Linyi UniversityInstitute of Microbe and Host Health, Linyi UniversityInstitute of Microbe and Host Health, Linyi UniversityAbstract The coinfection of ALVs (ALV-J plus ALV-A or/and ALV-B) has played an important role in the incidence of tumors recently found in China in local breeds of yellow chickens. The study aims to obtain a better knowledge of the function and relevance of ALV coinfection in the clinical disease of avian leukosis, as well as its unique effect on the pathogenicity in Three-yellow chickens. One-day-old Three-yellow chicks (one day old) were infected with ALV-A, ALV-B, and ALV-J mono-infections, as well as ALV-A + J, ALV-B + J, and ALV-A + B + J coinfections, via intraperitoneal injection, and the chicks were then grown in isolators until they were 15 weeks old. The parameters, including the suppression of body weight gain, immune organ weight, viremia, histopathological changes and tumor incidence, were observed and compared with those of the uninfected control birds. The results demonstrated that coinfection with ALVs could induce more serious suppression of body weight gain (P < 0.05), damage to immune organs (P < 0.05) and higher tumor incidences than monoinfection, with triple infection producing the highest pathogenicity. The emergence of visible tumors and viremia occurred faster in the coinfected birds than in the monoinfected birds. These findings demonstrated that ALV coinfection resulted in considerably severe pathogenic and immunosuppressive consequences.https://doi.org/10.1186/s12917-024-03896-1CoinfectionMonoinfectionAvian leukosis virusPathogenicityThree-yellow chickens |
| spellingShingle | Peikun Wang Jing Wang Na Wang Cong Xue Zhaoqing Han The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens BMC Veterinary Research Coinfection Monoinfection Avian leukosis virus Pathogenicity Three-yellow chickens |
| title | The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens |
| title_full | The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens |
| title_fullStr | The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens |
| title_full_unstemmed | The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens |
| title_short | The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens |
| title_sort | coinfection of alvs causes severe pathogenicity in three yellow chickens |
| topic | Coinfection Monoinfection Avian leukosis virus Pathogenicity Three-yellow chickens |
| url | https://doi.org/10.1186/s12917-024-03896-1 |
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