Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study
Objectives: To investigate the preventive effect of intraarticularly administered vancomycin on acute postoperative periprosthetic joint infection (PJI) in total joint arthroplasty (TJA). Methods: Consecutive patients who underwent unilateral primary TJA were prospectively enrolled. The patients wer...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223007166 |
| _version_ | 1827806026296983552 |
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| author | Mingwei Hu Yifan Zhang Xue Yang Yingzhen Wang Hao Xu Shuai Xiang |
| author_facet | Mingwei Hu Yifan Zhang Xue Yang Yingzhen Wang Hao Xu Shuai Xiang |
| author_sort | Mingwei Hu |
| collection | DOAJ |
| description | Objectives: To investigate the preventive effect of intraarticularly administered vancomycin on acute postoperative periprosthetic joint infection (PJI) in total joint arthroplasty (TJA). Methods: Consecutive patients who underwent unilateral primary TJA were prospectively enrolled. The patients were divided into vancomycin group and control group according to whether 1 g of vancomycin powder suspended in 30 ml normal saline was intraarticularly administered after arthrotomy closure. Acute postoperative PJI and aseptic wound complication were evaluated within 3 months postoperatively. Vancomycin-associated toxicity including acute renal failure, ototoxicity and anaphylaxis was also evaluated. Results: In terms of demographic parameters and comorbidities, no significant difference was found between the two groups. Intra-articular vancomycin significantly lowered the risk of acute postoperative PJI after primary TJA (P = 0.015) and primary total knee arthroplasty (P = 0.031). However, for patients who underwent total hip arthroplasty, the PJI rate was comparable between the two groups. Overall, the risk of aseptic wound complication between the two groups was also similar. Vancomycin-associated acute renal injury, ototoxicity, or anaphylaxis was not observed. Conclusions: Intra-articular injection of 1 g of vancomycin suspension after arthrotomy closure during TJA lowered the risk of acute postoperative PJI without increasing the risk of aseptic wound complication and vancomycin-associated systemic toxicity. |
| first_indexed | 2024-03-11T21:34:36Z |
| format | Article |
| id | doaj.art-301785604ea14ee78920c1d4fc7aa19e |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-11T21:34:36Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-301785604ea14ee78920c1d4fc7aa19e2023-09-27T04:42:04ZengElsevierInternational Journal of Infectious Diseases1201-97122023-11-011366469Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective studyMingwei Hu0Yifan Zhang1Xue Yang2Yingzhen Wang3Hao Xu4Shuai Xiang5Department of Joint Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Joint Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Operation Room, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Joint Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Joint Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Joint Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Corresponding author.Objectives: To investigate the preventive effect of intraarticularly administered vancomycin on acute postoperative periprosthetic joint infection (PJI) in total joint arthroplasty (TJA). Methods: Consecutive patients who underwent unilateral primary TJA were prospectively enrolled. The patients were divided into vancomycin group and control group according to whether 1 g of vancomycin powder suspended in 30 ml normal saline was intraarticularly administered after arthrotomy closure. Acute postoperative PJI and aseptic wound complication were evaluated within 3 months postoperatively. Vancomycin-associated toxicity including acute renal failure, ototoxicity and anaphylaxis was also evaluated. Results: In terms of demographic parameters and comorbidities, no significant difference was found between the two groups. Intra-articular vancomycin significantly lowered the risk of acute postoperative PJI after primary TJA (P = 0.015) and primary total knee arthroplasty (P = 0.031). However, for patients who underwent total hip arthroplasty, the PJI rate was comparable between the two groups. Overall, the risk of aseptic wound complication between the two groups was also similar. Vancomycin-associated acute renal injury, ototoxicity, or anaphylaxis was not observed. Conclusions: Intra-articular injection of 1 g of vancomycin suspension after arthrotomy closure during TJA lowered the risk of acute postoperative PJI without increasing the risk of aseptic wound complication and vancomycin-associated systemic toxicity.http://www.sciencedirect.com/science/article/pii/S1201971223007166ArthroplastyIntraarticularVancomycinPeriprosthetic joint infection |
| spellingShingle | Mingwei Hu Yifan Zhang Xue Yang Yingzhen Wang Hao Xu Shuai Xiang Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study International Journal of Infectious Diseases Arthroplasty Intraarticular Vancomycin Periprosthetic joint infection |
| title | Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study |
| title_full | Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study |
| title_fullStr | Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study |
| title_full_unstemmed | Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study |
| title_short | Intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty—a prospective study |
| title_sort | intraarticular vancomycin decreased the risk of acute postoperative periprosthetic joint infection without increasing complication in primary total joint arthroplasty a prospective study |
| topic | Arthroplasty Intraarticular Vancomycin Periprosthetic joint infection |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223007166 |
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